ID   CLD5_BOVIN              Reviewed;         218 AA.
AC   Q2HJ22;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Claudin-5;
GN   Name=CLDN5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
CC       Interacts with MPDZ (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR   EMBL; BC113349; AAI13350.1; -; mRNA.
DR   RefSeq; NP_001069928.1; NM_001076460.1.
DR   AlphaFoldDB; Q2HJ22; -.
DR   SMR; Q2HJ22; -.
DR   STRING; 9913.ENSBTAP00000029418; -.
DR   PaxDb; Q2HJ22; -.
DR   Ensembl; ENSBTAT00000029418; ENSBTAP00000029418; ENSBTAG00000022020.
DR   GeneID; 617453; -.
DR   KEGG; bta:617453; -.
DR   CTD; 7122; -.
DR   VEuPathDB; HostDB:ENSBTAG00000022020; -.
DR   VGNC; VGNC:27417; CLDN5.
DR   eggNOG; ENOG502QW5D; Eukaryota.
DR   GeneTree; ENSGT00940000161769; -.
DR   HOGENOM; CLU_076370_1_2_1; -.
DR   InParanoid; Q2HJ22; -.
DR   OMA; IPLCWFA; -.
DR   OrthoDB; 1400747at2759; -.
DR   TreeFam; TF331936; -.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000022020; Expressed in bone marrow and 102 other tissues.
DR   GO; GO:0016327; C:apicolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0005923; C:bicellular tight junction; IDA:AgBase.
DR   GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:1990963; P:establishment of blood-retinal barrier; IEA:Ensembl.
DR   GO; GO:0035633; P:maintenance of blood-brain barrier; IEA:Ensembl.
DR   GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0043116; P:negative regulation of vascular permeability; IEA:Ensembl.
DR   GO; GO:1903348; P:positive regulation of bicellular tight junction assembly; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:1903142; P:positive regulation of establishment of endothelial barrier; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR003551; Claudin5.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01380; CLAUDIN5.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..218
FT                   /note="Claudin-5"
FT                   /id="PRO_0000244416"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..122
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..218
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          217..218
FT                   /note="Interactions with TJP1, TJP2 and TJP3"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   218 AA;  23017 MW;  FAE468DCAA4F2597 CRC64;
     MGSAALEILG LVLCLVGWVG LILACGLPMW QVTAFLDHNI VTAQTTWKGL WMSCVVQSTG
     HMQCKVYDSV LALSPEVQAA RALTVGAVLL ALVALFVTLA GAQCTTCVAP GPAKARVALT
     GGALYALCGL LALVPLCWFA NIVVREFYDP TVPMSQKYEL GAALYIGWAA SALLMCGGGL
     VCCGAWVCTG RPDFSFPVKY SASRRPTATG DYDKKNYV