CLD5_RAT
ID CLD5_RAT Reviewed; 218 AA.
AC Q9JKD6; Q66H22;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Claudin-5;
GN Name=Cldn5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 10-215.
RA Kirsch T., Wellner M., Haller H., Lippoldt A.;
RT "Cloning of rat claudin-5.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INTERACTION WITH MPDZ.
RX PubMed=12403818; DOI=10.1083/jcb.200207050;
RA Poliak S., Matlis S., Ullmer C., Scherer S.S., Peles E.;
RT "Distinct claudins and associated PDZ proteins form different autotypic
RT tight junctions in myelinating Schwann cells.";
RL J. Cell Biol. 159:361-372(2002).
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By
CC similarity). Interacts with MPDZ. {ECO:0000250,
CC ECO:0000269|PubMed:12403818}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR EMBL; BC082073; AAH82073.1; -; mRNA.
DR EMBL; AF241260; AAF73425.1; -; mRNA.
DR RefSeq; NP_113889.1; NM_031701.2.
DR AlphaFoldDB; Q9JKD6; -.
DR SMR; Q9JKD6; -.
DR STRING; 10116.ENSRNOP00000064048; -.
DR iPTMnet; Q9JKD6; -.
DR PhosphoSitePlus; Q9JKD6; -.
DR PaxDb; Q9JKD6; -.
DR Ensembl; ENSRNOT00000072027; ENSRNOP00000066206; ENSRNOG00000050071.
DR GeneID; 65131; -.
DR KEGG; rno:65131; -.
DR CTD; 7122; -.
DR RGD; 68431; Cldn5.
DR eggNOG; ENOG502QW5D; Eukaryota.
DR GeneTree; ENSGT00940000161769; -.
DR HOGENOM; CLU_076370_1_2_1; -.
DR InParanoid; Q9JKD6; -.
DR OMA; IPLCWFA; -.
DR OrthoDB; 1400747at2759; -.
DR PhylomeDB; Q9JKD6; -.
DR PRO; PR:Q9JKD6; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000045811; Expressed in lung and 20 other tissues.
DR Genevisible; Q9JKD6; RN.
DR GO; GO:0016327; C:apicolateral plasma membrane; ISO:RGD.
DR GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB.
DR GO; GO:0005911; C:cell-cell junction; ISO:RGD.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016328; C:lateral plasma membrane; IDA:RGD.
DR GO; GO:0033270; C:paranode region of axon; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0043220; C:Schmidt-Lanterman incisure; IDA:RGD.
DR GO; GO:0070160; C:tight junction; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0005198; F:structural molecule activity; TAS:RGD.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; ISO:RGD.
DR GO; GO:1990963; P:establishment of blood-retinal barrier; ISO:RGD.
DR GO; GO:0035633; P:maintenance of blood-brain barrier; ISO:RGD.
DR GO; GO:0042552; P:myelination; IPI:RGD.
DR GO; GO:0016525; P:negative regulation of angiogenesis; ISO:RGD.
DR GO; GO:0030336; P:negative regulation of cell migration; ISO:RGD.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR GO; GO:0043116; P:negative regulation of vascular permeability; ISO:RGD.
DR GO; GO:1903348; P:positive regulation of bicellular tight junction assembly; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:1903142; P:positive regulation of establishment of endothelial barrier; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:0032092; P:positive regulation of protein binding; ISO:RGD.
DR GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR GO; GO:0120192; P:tight junction assembly; ISO:RGD.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR003551; Claudin5.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01380; CLAUDIN5.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 1: Evidence at protein level;
KW Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..218
FT /note="Claudin-5"
FT /id="PRO_0000144747"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 217..218
FT /note="Interactions with TJP1, TJP2 and TJP3"
FT /evidence="ECO:0000250"
SQ SEQUENCE 218 AA; 23072 MW; 93A316815D8D7F3D CRC64;
MGSAALEILG LVLCLVGWVG LILACGLPMW QVTAFLDHNI VTAQTTWKGL WMSCVVQSTG
HMQCKVYESV LALSAEVQAA RALTVGAVLL ALVALFVTLT GAQCTTCVAP GPVKARVALT
GGALYALCGL LALVPLCWFA NIVVREFYDP TVPVSQKYEL GAALYIGWAA SALLMCGGGL
VCCGAWVCTG RPEFSFPVKY SAPRRTTANG DYDKKNYV
