ID   CLD7A_DANRE             Reviewed;         212 AA.
AC   Q6DHP1;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Claudin-7-A {ECO:0000312|ZFIN:ZDB-GENE-040718-29};
GN   Name=cldn7a {ECO:0000312|ZFIN:ZDB-GENE-040718-29}; ORFNames=zgc:92192;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH75926.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space. {ECO:0000250|UniProtKB:O95471}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000250|UniProtKB:O95471}. Cell membrane
CC       {ECO:0000250|UniProtKB:O95471}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O95471}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000255}.
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DR   EMBL; BC075926; AAH75926.1; -; mRNA.
DR   EMBL; BC153583; AAI53584.1; -; mRNA.
DR   RefSeq; NP_001002340.1; NM_001002340.1.
DR   AlphaFoldDB; Q6DHP1; -.
DR   SMR; Q6DHP1; -.
DR   STRING; 7955.ENSDARP00000052843; -.
DR   PaxDb; Q6DHP1; -.
DR   Ensembl; ENSDART00000052844; ENSDARP00000052843; ENSDARG00000036376.
DR   Ensembl; ENSDART00000190401; ENSDARP00000155926; ENSDARG00000111721.
DR   Ensembl; ENSDART00000192390; ENSDARP00000153652; ENSDARG00000115826.
DR   GeneID; 436612; -.
DR   KEGG; dre:436612; -.
DR   CTD; 436612; -.
DR   ZFIN; ZDB-GENE-040718-29; cldn7a.
DR   eggNOG; ENOG502QPXX; Eukaryota.
DR   GeneTree; ENSGT00940000166258; -.
DR   HOGENOM; CLU_076370_2_3_1; -.
DR   InParanoid; Q6DHP1; -.
DR   OMA; GNSQANI; -.
DR   OrthoDB; 1244077at2759; -.
DR   PhylomeDB; Q6DHP1; -.
DR   TreeFam; TF331936; -.
DR   PRO; PR:Q6DHP1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000036376; Expressed in zone of skin and 14 other tissues.
DR   GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0060322; P:head development; IMP:ZFIN.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..212
FT                   /note="Claudin-7-A"
FT                   /id="PRO_0000397925"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..119
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..212
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          191..212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   212 AA;  22366 MW;  DF85FF0C29AC0204 CRC64;
     MANSGVQLLG FGLSLIGIIG LIVGTILPQW KMSAYVGDSI ITAVATYQGL WMSCAFQSTG
     QLQCKIYDSI LQLDSDLQAT RALMIVGIIV SIAGLGVASI GMKCTTCGAD DKVRKTRTAM
     TGGIILLVGA LCAVVACSWF AHNVIRAFYN PFTPVNTKFE FGAAIFIAWG GSFLDVLGGA
     MLAASCPRSK QVSKYPKSNS TRSANGSNKE YV