ID   CLD7B_DANRE             Reviewed;         215 AA.
AC   Q9YH92;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Claudin-7-B;
DE   AltName: Full=Claudin-like protein ZF4A22;
GN   Name=cldn7b; Synonyms=cldn7;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Keen T.J., Inglehearn C.F.;
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11071763; DOI=10.1006/dbio.2000.9924;
RA   Chin A.J., Tsang M., Weinberg E.S.;
RT   "Heart and gut chiralities are controlled independently from initial heart
RT   position in the developing zebrafish.";
RL   Dev. Biol. 227:403-421(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR   EMBL; AJ011788; CAA09776.1; -; mRNA.
DR   EMBL; AF260240; AAG24512.1; -; mRNA.
DR   EMBL; BC048367; AAH48367.1; -; mRNA.
DR   EMBL; BC066408; AAH66408.1; -; mRNA.
DR   RefSeq; NP_571712.1; NM_131637.1.
DR   AlphaFoldDB; Q9YH92; -.
DR   SMR; Q9YH92; -.
DR   STRING; 7955.ENSDARP00000004546; -.
DR   PaxDb; Q9YH92; -.
DR   Ensembl; ENSDART00000006173; ENSDARP00000004546; ENSDARG00000014047.
DR   Ensembl; ENSDART00000167651; ENSDARP00000137470; ENSDARG00000114912.
DR   GeneID; 60635; -.
DR   KEGG; dre:60635; -.
DR   CTD; 60635; -.
DR   ZFIN; ZDB-GENE-001103-5; cldn7b.
DR   eggNOG; ENOG502QPXX; Eukaryota.
DR   GeneTree; ENSGT00940000160672; -.
DR   HOGENOM; CLU_076370_1_2_1; -.
DR   InParanoid; Q9YH92; -.
DR   OMA; WYTHDIV; -.
DR   OrthoDB; 1244077at2759; -.
DR   PhylomeDB; Q9YH92; -.
DR   TreeFam; TF331936; -.
DR   PRO; PR:Q9YH92; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 10.
DR   Bgee; ENSDARG00000014047; Expressed in early embryo and 26 other tissues.
DR   GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0034332; P:adherens junction organization; IMP:ZFIN.
DR   GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0090136; P:epithelial cell-cell adhesion; IMP:ZFIN.
DR   GO; GO:0048840; P:otolith development; IMP:ZFIN.
DR   GO; GO:0060876; P:semicircular canal formation; IMP:ZFIN.
DR   GO; GO:0007605; P:sensory perception of sound; IMP:ZFIN.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..215
FT                   /note="Claudin-7-B"
FT                   /id="PRO_0000144789"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..117
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..211
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          186..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   215 AA;  22865 MW;  BC04870B75B8CB9D CRC64;
     MAHKGLQLLG FTLSLLGLIG LIIGTIMPQW KMSAYVGDNI ITAIAMYQGL WMSCAYQSTG
     QQQCKVYDSV LQLDSALQAT RALMVVAILL TVAGLGVASM GMKCTNCGGD DKVKKSRIAM
     TGGIILSVGA LCSIVACGWF TSQIIRDFYN PFTPVNTKYE FGAAIFIAWA GAFLDIMGGG
     MLASSCSKGQ SSPNYPKSSR PVKSSRPPSS SKEYV