ID   CLD7_BOVIN              Reviewed;         211 AA.
AC   Q3B7N4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Claudin-7;
GN   Name=CLDN7;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
CC       The phosphorylated form interacts with EPCAM.
CC       {ECO:0000250|UniProtKB:O95471, ECO:0000250|UniProtKB:Q9Z261}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O95471};
CC       Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane
CC       {ECO:0000250|UniProtKB:O95471}. Cell junction, tight junction
CC       {ECO:0000250|UniProtKB:O95471}. Note=Colocalizes with EPCAM at the
CC       basolateral cell membrane and tight junction.
CC       {ECO:0000250|UniProtKB:O95471}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR   EMBL; BC107530; AAI07531.1; -; mRNA.
DR   RefSeq; NP_001035609.1; NM_001040519.2.
DR   RefSeq; XP_010814219.1; XM_010815917.2.
DR   AlphaFoldDB; Q3B7N4; -.
DR   SMR; Q3B7N4; -.
DR   STRING; 9913.ENSBTAP00000025906; -.
DR   PaxDb; Q3B7N4; -.
DR   Ensembl; ENSBTAT00000025906; ENSBTAP00000025906; ENSBTAG00000019448.
DR   GeneID; 512975; -.
DR   KEGG; bta:512975; -.
DR   CTD; 1366; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019448; -.
DR   VGNC; VGNC:55796; CLDN7.
DR   eggNOG; ENOG502QPXX; Eukaryota.
DR   GeneTree; ENSGT00940000160672; -.
DR   HOGENOM; CLU_076370_1_2_1; -.
DR   InParanoid; Q3B7N4; -.
DR   OMA; ACAWCTH; -.
DR   OrthoDB; 1244077at2759; -.
DR   TreeFam; TF331936; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000019448; Expressed in ascending colon and 82 other tissues.
DR   GO; GO:0016327; C:apicolateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR003552; Claudin7.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01381; CLAUDIN7.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Membrane; Phosphoprotein; Reference proteome;
KW   Tight junction; Transmembrane; Transmembrane helix.
FT   CHAIN           1..211
FT                   /note="Claudin-7"
FT                   /id="PRO_0000244417"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..117
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        139..160
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..211
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          190..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..211
FT                   /note="Interactions with TJP1, TJP2 and TJP3"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   211 AA;  22371 MW;  293D6C5664E7D85D CRC64;
     MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG
     MMSCKMYDSV LSLPAALQAT RALMVVSLVL GFLATFVATM GMKCTNCGGD DKVKKARIAM
     TGGIIFILAG LAALIACSWY GHQIVSDFYN PLVPMNVKYE FGPAIFIGWA GSALVLLGGA
     LLSCSCPGSE SKAGYRAPRS YPKPNSAKEY V