CLD7_HUMAN
ID CLD7_HUMAN Reviewed; 211 AA.
AC O95471; B2R9X7; D3DTP0; Q6IPN3; Q7Z4Y7; Q9BVN0;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 4.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Claudin-7;
DE Short=CLDN-7;
GN Name=CLDN7; Synonyms=CEPTRL2, CPETRL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ALA-197.
RC TISSUE=Colon adenocarcinoma;
RA Keen T.J.;
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-197.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS THR-133
RP AND ALA-197.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS THR-133
RP AND ALA-197.
RC TISSUE=Mammary gland, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 13-211 (ISOFORM 1), AND VARIANT ALA-197.
RA Yue P., Yu L., Bi A.D., Zhang M., He H., Zhao S.Y.;
RT "Cloning and expression of a novel human cDNA homology to murine claudin-1
RT mRNA.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, INDUCTION, AND TISSUE
RP SPECIFICITY.
RX PubMed=14502431; DOI=10.1007/s00232-003-2038-4;
RA Zheng J.-Y., Yu D., Foroohar M., Ko E., Chan J., Kim N., Chiu R., Pang S.;
RT "Regulation of the expression of the prostate-specific antigen by claudin-
RT 7.";
RL J. Membr. Biol. 194:187-197(2003).
RN [9]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=12673207; DOI=10.1038/sj.onc.1206199;
RA Kominsky S.L., Argani P., Korz D., Evron E., Raman V., Garrett E., Rein A.,
RA Sauter G., Kallioniemi O.-P., Sukumar S.;
RT "Loss of the tight junction protein claudin-7 correlates with histological
RT grade in both ductal carcinoma in situ and invasive ductal carcinoma of the
RT breast.";
RL Oncogene 22:2021-2033(2003).
RN [10]
RP SUBCELLULAR LOCATION, PHOSPHORYLATION, AND INTERACTION WITH EPCAM.
RX PubMed=16054130; DOI=10.1016/j.yexcr.2005.06.013;
RA Ladwein M., Pape U.F., Schmidt D.S., Schnoelzer M., Fiedler S.,
RA Langbein L., Franke W.W., Moldenhauer G., Zoeller M.;
RT "The cell-cell adhesion molecule EpCAM interacts directly with the tight
RT junction protein claudin-7.";
RL Exp. Cell Res. 309:345-357(2005).
RN [11]
RP SUBCELLULAR LOCATION, MUTAGENESIS OF MET-32 AND LYS-48, AND ABSENCE OF
RP INTERACTION WITH CD81.
RX PubMed=20375010; DOI=10.1074/jbc.m110.104836;
RA Harris H.J., Davis C., Mullins J.G., Hu K., Goodall M., Farquhar M.J.,
RA Mee C.J., McCaffrey K., Young S., Drummer H., Balfe P., McKeating J.A.;
RT "Claudin association with CD81 defines hepatitis C virus entry.";
RL J. Biol. Chem. 285:21092-21102(2010).
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By
CC similarity). The phosphorylated form interacts with EPCAM
CC (PubMed:16054130). Does not interact with CD81 (PubMed:20375010).
CC {ECO:0000250|UniProtKB:Q9Z261, ECO:0000269|PubMed:16054130,
CC ECO:0000269|PubMed:20375010}.
CC -!- INTERACTION:
CC O95471; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-740744, EBI-11957045;
CC O95471; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-740744, EBI-12109402;
CC O95471; P05090: APOD; NbExp=3; IntAct=EBI-740744, EBI-715495;
CC O95471; P07306: ASGR1; NbExp=3; IntAct=EBI-740744, EBI-1172335;
CC O95471; Q92843: BCL2L2; NbExp=3; IntAct=EBI-740744, EBI-707714;
CC O95471; O15155: BET1; NbExp=3; IntAct=EBI-740744, EBI-749204;
CC O95471; O95393: BMP10; NbExp=3; IntAct=EBI-740744, EBI-3922513;
CC O95471; P19397: CD53; NbExp=3; IntAct=EBI-740744, EBI-6657396;
CC O95471; P21854: CD72; NbExp=3; IntAct=EBI-740744, EBI-307924;
CC O95471; Q9NWW5: CLN6; NbExp=3; IntAct=EBI-740744, EBI-6165897;
CC O95471; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-740744, EBI-11522780;
CC O95471; O95406: CNIH1; NbExp=3; IntAct=EBI-740744, EBI-12172273;
CC O95471; P29400-2: COL4A5; NbExp=3; IntAct=EBI-740744, EBI-12211159;
CC O95471; Q07325: CXCL9; NbExp=3; IntAct=EBI-740744, EBI-3911467;
CC O95471; Q8NBI2: CYB561A3; NbExp=3; IntAct=EBI-740744, EBI-10269179;
CC O95471; O14569: CYB561D2; NbExp=3; IntAct=EBI-740744, EBI-717654;
CC O95471; O43169: CYB5B; NbExp=3; IntAct=EBI-740744, EBI-1058710;
CC O95471; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-740744, EBI-2680384;
CC O95471; P56851: EDDM3B; NbExp=3; IntAct=EBI-740744, EBI-10215665;
CC O95471; P54852: EMP3; NbExp=3; IntAct=EBI-740744, EBI-3907816;
CC O95471; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-740744, EBI-711490;
CC O95471; Q7Z2K6: ERMP1; NbExp=3; IntAct=EBI-740744, EBI-10976398;
CC O95471; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-740744, EBI-12142299;
CC O95471; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-740744, EBI-713304;
CC O95471; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-740744, EBI-6166686;
CC O95471; O60883: GPR37L1; NbExp=3; IntAct=EBI-740744, EBI-2927498;
CC O95471; P24593: IGFBP5; NbExp=3; IntAct=EBI-740744, EBI-720480;
CC O95471; O43736: ITM2A; NbExp=3; IntAct=EBI-740744, EBI-2431769;
CC O95471; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-740744, EBI-10266796;
CC O95471; O43561-2: LAT; NbExp=3; IntAct=EBI-740744, EBI-8070286;
CC O95471; O95214: LEPROTL1; NbExp=3; IntAct=EBI-740744, EBI-750776;
CC O95471; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-740744, EBI-12033434;
CC O95471; Q8N112: LSMEM2; NbExp=3; IntAct=EBI-740744, EBI-10264855;
CC O95471; P21145: MAL; NbExp=3; IntAct=EBI-740744, EBI-3932027;
CC O95471; Q13021: MALL; NbExp=3; IntAct=EBI-740744, EBI-750078;
CC O95471; Q6N075: MFSD5; NbExp=3; IntAct=EBI-740744, EBI-3920969;
CC O95471; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-740744, EBI-12070086;
CC O95471; Q9NX14: NDUFB11; NbExp=3; IntAct=EBI-740744, EBI-1246182;
CC O95471; Q0D2K0: NIPAL4; NbExp=3; IntAct=EBI-740744, EBI-9550165;
CC O95471; Q16617: NKG7; NbExp=3; IntAct=EBI-740744, EBI-3919611;
CC O95471; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-740744, EBI-2804156;
CC O95471; Q9UHJ9-5: PGAP2; NbExp=3; IntAct=EBI-740744, EBI-12092917;
CC O95471; P26678: PLN; NbExp=3; IntAct=EBI-740744, EBI-692836;
CC O95471; Q9NS64: RPRM; NbExp=3; IntAct=EBI-740744, EBI-1052363;
CC O95471; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-740744, EBI-10244780;
CC O95471; Q969E2: SCAMP4; NbExp=3; IntAct=EBI-740744, EBI-4403649;
CC O95471; Q14162: SCARF1; NbExp=3; IntAct=EBI-740744, EBI-12056025;
CC O95471; O75396: SEC22B; NbExp=3; IntAct=EBI-740744, EBI-1058865;
CC O95471; A2A2V5: SERTM1; NbExp=3; IntAct=EBI-740744, EBI-17284533;
CC O95471; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-740744, EBI-10314552;
CC O95471; Q8N205: SYNE4; NbExp=3; IntAct=EBI-740744, EBI-7131783;
CC O95471; Q9NV29: TMEM100; NbExp=3; IntAct=EBI-740744, EBI-8644968;
CC O95471; P17152: TMEM11; NbExp=3; IntAct=EBI-740744, EBI-723946;
CC O95471; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-740744, EBI-10694905;
CC O95471; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-740744, EBI-2844246;
CC O95471; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-740744, EBI-348587;
CC O95471; Q2T9K0-2: TMEM44; NbExp=3; IntAct=EBI-740744, EBI-13076526;
CC O95471; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-740744, EBI-2852148;
CC O95471; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-740744, EBI-12111910;
CC O95471; P01375: TNF; NbExp=3; IntAct=EBI-740744, EBI-359977;
CC O95471; Q86UF1: TSPAN33; NbExp=3; IntAct=EBI-740744, EBI-12045841;
CC O95471; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-740744, EBI-10243654;
CC O95471; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-740744, EBI-11988865;
CC O95471; Q9Y5Z9: UBIAD1; NbExp=3; IntAct=EBI-740744, EBI-2819725;
CC O95471; Q9H1C4: UNC93B1; NbExp=3; IntAct=EBI-740744, EBI-4401271;
CC O95471; O75841: UPK1B; NbExp=3; IntAct=EBI-740744, EBI-12237619;
CC O95471; O00526: UPK2; NbExp=3; IntAct=EBI-740744, EBI-10179682;
CC O95471; Q15836: VAMP3; NbExp=3; IntAct=EBI-740744, EBI-722343;
CC O95471; O95183: VAMP5; NbExp=3; IntAct=EBI-740744, EBI-10191195;
CC O95471; Q6UX27-3: VSTM1; NbExp=3; IntAct=EBI-740744, EBI-12190699;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12673207,
CC ECO:0000269|PubMed:14502431, ECO:0000269|PubMed:20375010}; Multi-pass
CC membrane protein {ECO:0000255}. Basolateral cell membrane
CC {ECO:0000269|PubMed:16054130}. Cell junction, tight junction
CC {ECO:0000269|PubMed:16054130}. Note=Co-localizes with EPCAM at the
CC basolateral cell membrane and tight junction.
CC {ECO:0000269|PubMed:16054130}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O95471-1; Sequence=Displayed;
CC Name=2; Synonyms=t-CLDN-7;
CC IsoId=O95471-2; Sequence=VSP_013230;
CC -!- TISSUE SPECIFICITY: Expressed in kidney, lung and prostate. Isoform 1
CC seems to be predominant, except in some normal prostate samples, where
CC isoform 2 is the major form. Down-regulated in breast cancers,
CC including ductal carcinoma in situ (DCIS), lobular carcinoma in situ
CC (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well
CC as in several cancer cell lines. Loss of expression correlates with
CC histological grade, occurring predominantly in high-grade lesions.
CC {ECO:0000269|PubMed:12673207, ECO:0000269|PubMed:14502431}.
CC -!- INDUCTION: By androgens. {ECO:0000269|PubMed:14502431}.
CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:16054130}.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP97219.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/CLDN7ID40099ch17p13.html";
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DR EMBL; AJ011497; CAA09626.1; -; mRNA.
DR EMBL; AK313958; BAG36674.1; -; mRNA.
DR EMBL; BT006829; AAP35475.1; -; mRNA.
DR EMBL; AC003688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471108; EAW90228.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90229.1; -; Genomic_DNA.
DR EMBL; BC001055; AAH01055.1; -; mRNA.
DR EMBL; BC071844; AAH71844.1; -; mRNA.
DR EMBL; AF093823; AAP97219.1; ALT_FRAME; mRNA.
DR CCDS; CCDS11096.1; -. [O95471-1]
DR RefSeq; NP_001171951.1; NM_001185022.1. [O95471-1]
DR RefSeq; NP_001171952.1; NM_001185023.1.
DR RefSeq; NP_001298.3; NM_001307.5. [O95471-1]
DR AlphaFoldDB; O95471; -.
DR SMR; O95471; -.
DR BioGRID; 107758; 81.
DR IntAct; O95471; 75.
DR MINT; O95471; -.
DR STRING; 9606.ENSP00000353475; -.
DR TCDB; 1.H.1.1.2; the claudin tight junction (claudin1) family.
DR iPTMnet; O95471; -.
DR PhosphoSitePlus; O95471; -.
DR BioMuta; CLDN7; -.
DR EPD; O95471; -.
DR jPOST; O95471; -.
DR MassIVE; O95471; -.
DR MaxQB; O95471; -.
DR PaxDb; O95471; -.
DR PeptideAtlas; O95471; -.
DR PRIDE; O95471; -.
DR ProteomicsDB; 50903; -. [O95471-1]
DR ProteomicsDB; 50904; -. [O95471-2]
DR Antibodypedia; 4583; 519 antibodies from 37 providers.
DR DNASU; 1366; -.
DR Ensembl; ENST00000360325.11; ENSP00000353475.7; ENSG00000181885.18. [O95471-1]
DR Ensembl; ENST00000397317.8; ENSP00000396638.3; ENSG00000181885.18. [O95471-1]
DR Ensembl; ENST00000672374.1; ENSP00000500460.1; ENSG00000288292.1. [O95471-1]
DR Ensembl; ENST00000672443.1; ENSP00000500298.1; ENSG00000288292.1. [O95471-1]
DR GeneID; 1366; -.
DR KEGG; hsa:1366; -.
DR MANE-Select; ENST00000360325.11; ENSP00000353475.7; NM_001307.6; NP_001298.3.
DR UCSC; uc002gfm.5; human. [O95471-1]
DR CTD; 1366; -.
DR DisGeNET; 1366; -.
DR GeneCards; CLDN7; -.
DR HGNC; HGNC:2049; CLDN7.
DR HPA; ENSG00000181885; Tissue enhanced (esophagus, intestine).
DR MIM; 609131; gene.
DR neXtProt; NX_O95471; -.
DR OpenTargets; ENSG00000181885; -.
DR PharmGKB; PA26575; -.
DR VEuPathDB; HostDB:ENSG00000181885; -.
DR eggNOG; ENOG502QPXX; Eukaryota.
DR GeneTree; ENSGT00940000160672; -.
DR InParanoid; O95471; -.
DR OMA; ACAWCTH; -.
DR OrthoDB; 1244077at2759; -.
DR PhylomeDB; O95471; -.
DR TreeFam; TF331936; -.
DR PathwayCommons; O95471; -.
DR Reactome; R-HSA-420029; Tight junction interactions.
DR SignaLink; O95471; -.
DR SIGNOR; O95471; -.
DR BioGRID-ORCS; 1366; 9 hits in 1070 CRISPR screens.
DR ChiTaRS; CLDN7; human.
DR GeneWiki; CLDN7; -.
DR GenomeRNAi; 1366; -.
DR Pharos; O95471; Tbio.
DR PRO; PR:O95471; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O95471; protein.
DR Bgee; ENSG00000181885; Expressed in mucosa of transverse colon and 93 other tissues.
DR ExpressionAtlas; O95471; baseline and differential.
DR Genevisible; O95471; HS.
DR GO; GO:0016327; C:apicolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0050839; F:cell adhesion molecule binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0007162; P:negative regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:2000147; P:positive regulation of cell motility; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR003552; Claudin7.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01381; CLAUDIN7.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell junction; Cell membrane; Membrane;
KW Phosphoprotein; Reference proteome; Tight junction; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..211
FT /note="Claudin-7"
FT /id="PRO_0000144750"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..117
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..160
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 210..211
FT /note="Interactions with TJP1, TJP2 and TJP3"
FT /evidence="ECO:0000250"
FT VAR_SEQ 159..211
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_013230"
FT VARIANT 133
FT /note="A -> T (in dbSNP:rs17849410)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_030736"
FT VARIANT 197
FT /note="V -> A (in dbSNP:rs4562)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.3, ECO:0000269|Ref.7"
FT /id="VAR_014538"
FT MUTAGEN 32
FT /note="M->I: Interacts with CD81, and exhibits HCV
FT infection susceptibility in cell culture."
FT /evidence="ECO:0000269|PubMed:20375010"
FT MUTAGEN 48
FT /note="K->E: Interacts with CD81, and exhibits HCV
FT infection susceptibility in cell culture."
FT /evidence="ECO:0000269|PubMed:20375010"
FT CONFLICT 20
FT /note="G -> R (in Ref. 7; AAP97219)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 211 AA; 22418 MW; 7F3CC1B963D9006A CRC64;
MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG
MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM
GGGIIFIVAG LAALVACSWY GHQIVTDFYN PLIPTNIKYE FGPAIFIGWA GSALVILGGA
LLSCSCPGNE SKAGYRVPRS YPKSNSSKEY V
