CLD9_MOUSE
ID CLD9_MOUSE Reviewed; 217 AA.
AC Q9Z0S7; Q6PEA4;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Claudin-9;
GN Name=Cldn9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Morita K., Furuse M., Tsukita S.;
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC the intercellular space, through calcium-independent cell-adhesion
CC activity. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CLDN1, CD81 and OCLN.
CC {ECO:0000250|UniProtKB:O95484}.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane
CC {ECO:0000250|UniProtKB:O95484}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR EMBL; AF124424; AAD17319.1; -; Genomic_DNA.
DR EMBL; AC154766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466606; EDL22263.1; -; Genomic_DNA.
DR EMBL; BC058186; AAH58186.1; -; mRNA.
DR CCDS; CCDS28458.1; -.
DR RefSeq; NP_064689.2; NM_020293.3.
DR AlphaFoldDB; Q9Z0S7; -.
DR SMR; Q9Z0S7; -.
DR STRING; 10090.ENSMUSP00000093236; -.
DR PhosphoSitePlus; Q9Z0S7; -.
DR PaxDb; Q9Z0S7; -.
DR PRIDE; Q9Z0S7; -.
DR ProteomicsDB; 283380; -.
DR ABCD; Q9Z0S7; 9 sequenced antibodies.
DR Antibodypedia; 10653; 93 antibodies from 28 providers.
DR DNASU; 56863; -.
DR Ensembl; ENSMUST00000085989; ENSMUSP00000093236; ENSMUSG00000066720.
DR GeneID; 56863; -.
DR KEGG; mmu:56863; -.
DR UCSC; uc008asx.2; mouse.
DR CTD; 9080; -.
DR MGI; MGI:1913100; Cldn9.
DR VEuPathDB; HostDB:ENSMUSG00000066720; -.
DR eggNOG; ENOG502QRZ8; Eukaryota.
DR GeneTree; ENSGT00940000162145; -.
DR HOGENOM; CLU_076370_1_2_1; -.
DR InParanoid; Q9Z0S7; -.
DR OMA; YNPMVPD; -.
DR OrthoDB; 1231389at2759; -.
DR PhylomeDB; Q9Z0S7; -.
DR TreeFam; TF331936; -.
DR BioGRID-ORCS; 56863; 1 hit in 77 CRISPR screens.
DR PRO; PR:Q9Z0S7; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9Z0S7; protein.
DR Bgee; ENSMUSG00000066720; Expressed in vestibular epithelium and 103 other tissues.
DR Genevisible; Q9Z0S7; MM.
DR GO; GO:0005923; C:bicellular tight junction; IDA:MGI.
DR GO; GO:0030054; C:cell junction; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0001618; F:virus receptor activity; ISO:MGI.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0045216; P:cell-cell junction organization; IDA:MGI.
DR GO; GO:0120193; P:tight junction organization; IDA:MGI.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR003553; Claudin9.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR PANTHER; PTHR12002:SF42; PTHR12002:SF42; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01382; CLAUDIN9.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..217
FT /note="Claudin-9"
FT /id="PRO_0000144756"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..116
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..159
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 8
FT /note="L -> F (in Ref. 1; AAD17319)"
FT /evidence="ECO:0000305"
FT CONFLICT 11
FT /note="M -> R (in Ref. 1; AAD17319)"
FT /evidence="ECO:0000305"
FT CONFLICT 14
FT /note="A -> V (in Ref. 1; AAD17319)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 217 AA; 22897 MW; 793223BDB09DC398 CRC64;
MASTGLELLG MTLAVLGWLG TLVSCALPLW KVTAFIGNSI VVAQVVWEGL WMSCVVQSTG
QMQCKVYDSL LALPQDLQAA RALCVVALLL ALLGLLVAIT GAQCTTCVED EGAKARIVLT
AGVLLLLSGI LVLIPVCWTA HAIIQDFYNP LVAEALKREL GASLYLGWAA AALLMLGGGL
LCCTCPPSHF ERPRGPRLGY SIPSRSGASG LDKRDYV
