CLDN1_MOUSE
ID CLDN1_MOUSE Reviewed; 253 AA.
AC Q9CQX5; Q3U7C4;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Claudin domain-containing protein 1;
DE AltName: Full=Claudin-25;
GN Name=Cldnd1; Synonyms=Cldn25, D11Moh34;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Embryo, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-42.
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR EMBL; AK003808; BAB23007.1; -; mRNA.
DR EMBL; AK009432; BAB26284.1; -; mRNA.
DR EMBL; AK009743; BAB26473.1; -; mRNA.
DR EMBL; AK152121; BAE30964.1; -; mRNA.
DR EMBL; AK152722; BAE31445.1; -; mRNA.
DR EMBL; BC055695; AAH55695.1; -; mRNA.
DR CCDS; CCDS28234.1; -.
DR RefSeq; NP_741968.1; NM_171826.3.
DR RefSeq; XP_006522157.1; XM_006522094.3.
DR AlphaFoldDB; Q9CQX5; -.
DR IntAct; Q9CQX5; 1.
DR MINT; Q9CQX5; -.
DR STRING; 10090.ENSMUSP00000125497; -.
DR GlyConnect; 2217; 2 N-Linked glycans (1 site).
DR GlyGen; Q9CQX5; 2 sites, 2 N-linked glycans (1 site).
DR iPTMnet; Q9CQX5; -.
DR PhosphoSitePlus; Q9CQX5; -.
DR SwissPalm; Q9CQX5; -.
DR jPOST; Q9CQX5; -.
DR MaxQB; Q9CQX5; -.
DR PaxDb; Q9CQX5; -.
DR PeptideAtlas; Q9CQX5; -.
DR PRIDE; Q9CQX5; -.
DR ProteomicsDB; 283381; -.
DR Antibodypedia; 32146; 159 antibodies from 25 providers.
DR DNASU; 224250; -.
DR Ensembl; ENSMUST00000023426; ENSMUSP00000023426; ENSMUSG00000022744.
DR Ensembl; ENSMUST00000162057; ENSMUSP00000125497; ENSMUSG00000022744.
DR GeneID; 224250; -.
DR KEGG; mmu:224250; -.
DR UCSC; uc007zoc.2; mouse.
DR CTD; 56650; -.
DR MGI; MGI:2447860; Cldnd1.
DR VEuPathDB; HostDB:ENSMUSG00000022744; -.
DR eggNOG; ENOG502QRAV; Eukaryota.
DR GeneTree; ENSGT00390000002596; -.
DR HOGENOM; CLU_071844_0_0_1; -.
DR InParanoid; Q9CQX5; -.
DR OMA; NTHWYSP; -.
DR OrthoDB; 1047985at2759; -.
DR PhylomeDB; Q9CQX5; -.
DR TreeFam; TF331244; -.
DR BioGRID-ORCS; 224250; 1 hit in 54 CRISPR screens.
DR ChiTaRS; Cldnd1; mouse.
DR PRO; PR:Q9CQX5; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9CQX5; protein.
DR Bgee; ENSMUSG00000022744; Expressed in rostral migratory stream and 252 other tissues.
DR ExpressionAtlas; Q9CQX5; baseline and differential.
DR Genevisible; Q9CQX5; MM.
DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR042356; CLDN1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR14347; PTHR14347; 1.
DR Pfam; PF13903; Claudin_2; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..253
FT /note="Claudin domain-containing protein 1"
FT /id="PRO_0000164695"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 253 AA; 28572 MW; 46C1C28B0AFAC852 CRC64;
MDNRFATAFV IACVLSLIST IYMAASIGTD FWYEYRSPIQ ENSSDSNKIA WEDFLGDEAD
EKTYNDVLFR YNGSLGLWRR CITIPKNTHW YAPPERTESF DVVTKCMSFT LNEQFMEKYV
DPGNHNSGID LLRTYLWRCQ FLLPFVSLGL MCFGALIGLC ACICRSLYPT LATGILHLLA
GLCTLGSVSC YVAGIELLHQ KVELPKDVSG EFGWSFCLAC VSAPLQFMAA ALFIWAAHTN
RKEYTLMKAY RVA
