ID   CLDN1_PONAB             Reviewed;         253 AA.
AC   Q5RDV7; Q5R4X7; Q5R986;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Claudin domain-containing protein 1;
GN   Name=CLDND1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH91674.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR857787; CAH90050.1; -; mRNA.
DR   EMBL; CR859505; CAH91674.1; ALT_INIT; mRNA.
DR   EMBL; CR861112; CAH93189.1; -; mRNA.
DR   RefSeq; NP_001127451.1; NM_001133979.1.
DR   RefSeq; NP_001128766.1; NM_001135294.1.
DR   RefSeq; XP_009236929.1; XM_009238654.1.
DR   RefSeq; XP_009236930.1; XM_009238655.1.
DR   RefSeq; XP_009236931.1; XM_009238656.1.
DR   AlphaFoldDB; Q5RDV7; -.
DR   STRING; 9601.ENSPPYP00000015220; -.
DR   GeneID; 100174522; -.
DR   GeneID; 100189664; -.
DR   KEGG; pon:100174522; -.
DR   CTD; 56650; -.
DR   eggNOG; ENOG502QRAV; Eukaryota.
DR   HOGENOM; CLU_071844_0_0_1; -.
DR   InParanoid; Q5RDV7; -.
DR   OMA; NTHWYSP; -.
DR   OrthoDB; 1047985at2759; -.
DR   TreeFam; TF331244; -.
DR   Proteomes; UP000001595; Chromosome 3.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR042356; CLDN1.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR14347; PTHR14347; 1.
DR   Pfam; PF13903; Claudin_2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..253
FT                   /note="Claudin domain-containing protein 1"
FT                   /id="PRO_0000273424"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        72
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        161
FT                   /note="A -> V (in Ref. 1; CAH93189)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   253 AA;  28603 MW;  C6459D23B28C9885 CRC64;
     MDNRFATAFV IACVLSLIST IYMAASIGTD FWYEYRSPVQ ENSSDLNKSI WDEFISDEAD
     EKTYNDALFR YNGTVGLWRR CITIPKNMHW YSPPERTESF DVVTKCVSFT LTEQFMEKFV
     DPGNHNSGID LLRTYLWRCQ FLLPFVSLGL MCFGALIGLC ACICRSLYPT IATGILHLLA
     GLCTLGSVSC YVAGIELLHQ KLELPDNVSG EFGWSFCLAC VSAPLQFMAS ALFIWAAHTN
     RKEYTLMKAY RVA