CLDN2_HUMAN
ID CLDN2_HUMAN Reviewed; 167 AA.
AC Q8NHS1;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Claudin domain-containing protein 2;
GN Name=CLDND2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NHS1; Q8N6S4: ANKRD13C; NbExp=3; IntAct=EBI-11959453, EBI-11959451;
CC Q8NHS1; Q13520: AQP6; NbExp=3; IntAct=EBI-11959453, EBI-13059134;
CC Q8NHS1; P62952: BLCAP; NbExp=3; IntAct=EBI-11959453, EBI-3895726;
CC Q8NHS1; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-11959453, EBI-18013275;
CC Q8NHS1; Q15125: EBP; NbExp=3; IntAct=EBI-11959453, EBI-3915253;
CC Q8NHS1; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-11959453, EBI-18535450;
CC Q8NHS1; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-11959453, EBI-781551;
CC Q8NHS1; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-11959453, EBI-18304435;
CC Q8NHS1; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-11959453, EBI-18938272;
CC Q8NHS1; O15552: FFAR2; NbExp=3; IntAct=EBI-11959453, EBI-2833872;
CC Q8NHS1; Q8NBJ4: GOLM1; NbExp=3; IntAct=EBI-11959453, EBI-712073;
CC Q8NHS1; Q6ZVE7: GOLT1A; NbExp=3; IntAct=EBI-11959453, EBI-17231387;
CC Q8NHS1; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-11959453, EBI-13345167;
CC Q8NHS1; O60883: GPR37L1; NbExp=3; IntAct=EBI-11959453, EBI-2927498;
CC Q8NHS1; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-11959453, EBI-18053395;
CC Q8NHS1; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-11959453, EBI-2820517;
CC Q8NHS1; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-11959453, EBI-3923617;
CC Q8NHS1; P15941-11: MUC1; NbExp=3; IntAct=EBI-11959453, EBI-17263240;
CC Q8NHS1; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-11959453, EBI-7545592;
CC Q8NHS1; Q8NC24: RELL2; NbExp=3; IntAct=EBI-11959453, EBI-10269209;
CC Q8NHS1; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-11959453, EBI-3920694;
CC Q8NHS1; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-11959453, EBI-18159983;
CC Q8NHS1; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-11959453, EBI-8638294;
CC Q8NHS1; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-11959453, EBI-11742770;
CC Q8NHS1; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-11959453, EBI-11724433;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR EMBL; BC029518; AAH29518.1; -; mRNA.
DR CCDS; CCDS12829.1; -.
DR RefSeq; NP_689566.1; NM_152353.2.
DR AlphaFoldDB; Q8NHS1; -.
DR SMR; Q8NHS1; -.
DR BioGRID; 125932; 28.
DR IntAct; Q8NHS1; 25.
DR STRING; 9606.ENSP00000291715; -.
DR PhosphoSitePlus; Q8NHS1; -.
DR BioMuta; CLDND2; -.
DR DMDM; 74760361; -.
DR MassIVE; Q8NHS1; -.
DR PaxDb; Q8NHS1; -.
DR PeptideAtlas; Q8NHS1; -.
DR PRIDE; Q8NHS1; -.
DR Antibodypedia; 32471; 50 antibodies from 13 providers.
DR DNASU; 125875; -.
DR Ensembl; ENST00000291715.5; ENSP00000291715.1; ENSG00000160318.6.
DR Ensembl; ENST00000601435.1; ENSP00000472077.1; ENSG00000160318.6.
DR GeneID; 125875; -.
DR KEGG; hsa:125875; -.
DR MANE-Select; ENST00000291715.5; ENSP00000291715.1; NM_152353.3; NP_689566.1.
DR UCSC; uc002pwi.1; human.
DR CTD; 125875; -.
DR GeneCards; CLDND2; -.
DR HGNC; HGNC:28511; CLDND2.
DR HPA; ENSG00000160318; Tissue enhanced (testis).
DR neXtProt; NX_Q8NHS1; -.
DR OpenTargets; ENSG00000160318; -.
DR PharmGKB; PA144596447; -.
DR VEuPathDB; HostDB:ENSG00000160318; -.
DR eggNOG; ENOG502SPH8; Eukaryota.
DR GeneTree; ENSGT01050000244814; -.
DR HOGENOM; CLU_136294_0_0_1; -.
DR InParanoid; Q8NHS1; -.
DR OMA; RILCQEG; -.
DR OrthoDB; 1579117at2759; -.
DR PhylomeDB; Q8NHS1; -.
DR TreeFam; TF330587; -.
DR PathwayCommons; Q8NHS1; -.
DR SignaLink; Q8NHS1; -.
DR BioGRID-ORCS; 125875; 18 hits in 1070 CRISPR screens.
DR GenomeRNAi; 125875; -.
DR Pharos; Q8NHS1; Tdark.
DR PRO; PR:Q8NHS1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NHS1; protein.
DR Bgee; ENSG00000160318; Expressed in granulocyte and 98 other tissues.
DR ExpressionAtlas; Q8NHS1; baseline and differential.
DR Genevisible; Q8NHS1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR004032; PMP22_EMP_MP20.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PROSITE; PS01221; PMP22_1; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..167
FT /note="Claudin domain-containing protein 2"
FT /id="PRO_0000271020"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 167 AA; 17984 MW; E204F0B6366C22F2 CRC64;
MGVKRSLQSG GILLSLVANV LMVLSTATNY WTRQQEGHSG LWQECNHGIC SSIPCQTTLA
VTVACMVLAV GVGVVGMVMG LRIRCDEGES LRGQTTSAFL FLGGLLLLTA LIGYTVKNAW
KNNVFFSWSY FSGWLALPFS ILAGFCFLLA DMIMQSTDAI SGFPVCL
