CLDN2_MOUSE
ID CLDN2_MOUSE Reviewed; 167 AA.
AC Q9D9H2;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Claudin domain-containing protein 2;
GN Name=Cldnd2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. {ECO:0000305}.
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DR EMBL; AK006929; BAB24795.1; -; mRNA.
DR CCDS; CCDS39929.1; -.
DR RefSeq; NP_083125.1; NM_028849.1.
DR RefSeq; XP_017167841.1; XM_017312352.1.
DR AlphaFoldDB; Q9D9H2; -.
DR SMR; Q9D9H2; -.
DR STRING; 10090.ENSMUSP00000037980; -.
DR PhosphoSitePlus; Q9D9H2; -.
DR PaxDb; Q9D9H2; -.
DR PRIDE; Q9D9H2; -.
DR Antibodypedia; 32471; 50 antibodies from 13 providers.
DR Ensembl; ENSMUST00000040227; ENSMUSP00000037980; ENSMUSG00000038973.
DR Ensembl; ENSMUST00000206839; ENSMUSP00000145638; ENSMUSG00000038973.
DR GeneID; 74276; -.
DR KEGG; mmu:74276; -.
DR UCSC; uc009gms.1; mouse.
DR CTD; 125875; -.
DR MGI; MGI:1921526; Cldnd2.
DR VEuPathDB; HostDB:ENSMUSG00000038973; -.
DR eggNOG; ENOG502SPH8; Eukaryota.
DR GeneTree; ENSGT01050000244814; -.
DR HOGENOM; CLU_136294_0_0_1; -.
DR InParanoid; Q9D9H2; -.
DR OMA; RILCQEG; -.
DR OrthoDB; 1579117at2759; -.
DR PhylomeDB; Q9D9H2; -.
DR TreeFam; TF330587; -.
DR BioGRID-ORCS; 74276; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Cldnd2; mouse.
DR PRO; PR:Q9D9H2; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D9H2; protein.
DR Bgee; ENSMUSG00000038973; Expressed in seminiferous tubule of testis and 16 other tissues.
DR ExpressionAtlas; Q9D9H2; baseline and differential.
DR Genevisible; Q9D9H2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR Pfam; PF00822; PMP22_Claudin; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..167
FT /note="Claudin domain-containing protein 2"
FT /id="PRO_0000271021"
FT TRANSMEM 13..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 167 AA; 18250 MW; E1B2761C5A71121A CRC64;
MGVKKSLQTG GNLLNLLSSI LTVLSTTTNY WTRQQGGHSG LWQECTHGKC SNIPCQNTVA
VSAACMVLAA TFSIVALGIG IRIQCREAES RRSQNTIVLL FLSGLLLLIA LAVYTSKNAW
KPEVFFSWSY FFGWLALPFL FIAGFCFLLA DMILQSTEAI SGFPVCL
