CLDY_DANRE
ID CLDY_DANRE Reviewed; 208 AA.
AC Q9YH91;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Claudin-like protein ZF-A89;
DE AltName: Full=Claudin d;
GN Name=cldnd;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Keen T.J., Inglehearn C.F.;
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of tight junction (TJ) strands.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC junction, tight junction.
CC -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR EMBL; AJ011789; CAA09777.1; -; mRNA.
DR EMBL; BC078260; AAH78260.1; -; mRNA.
DR RefSeq; NP_851295.1; NM_180964.2.
DR AlphaFoldDB; Q9YH91; -.
DR SMR; Q9YH91; -.
DR STRING; 7955.ENSDARP00000025766; -.
DR PaxDb; Q9YH91; -.
DR Ensembl; ENSDART00000021620; ENSDARP00000025766; ENSDARG00000006580.
DR GeneID; 81583; -.
DR KEGG; dre:81583; -.
DR CTD; 81583; -.
DR ZFIN; ZDB-GENE-010328-4; cldnd.
DR eggNOG; ENOG502QSCN; Eukaryota.
DR GeneTree; ENSGT00940000164025; -.
DR HOGENOM; CLU_076370_1_2_1; -.
DR InParanoid; Q9YH91; -.
DR OMA; LLCCQCQ; -.
DR OrthoDB; 1231389at2759; -.
DR PhylomeDB; Q9YH91; -.
DR TreeFam; TF331936; -.
DR PRO; PR:Q9YH91; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 21.
DR Bgee; ENSDARG00000006580; Expressed in cleaving embryo and 20 other tissues.
DR GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR017974; Claudin_CS.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; PTHR12002; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PROSITE; PS01346; CLAUDIN; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..208
FT /note="Claudin-like protein ZF-A89"
FT /id="PRO_0000144790"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 208 AA; 22205 MW; 6A4BB5EBF3CCAB81 CRC64;
MASVGLQLLA TVLAIIGWLG EIVICALPMW KVTAFIGNNI VTAQIFWEGL WMNCVQQSTG
QMQCKVYDSM LALPQDLQAA RALVVISIIV TFMGVFLTIA GGKCTNCIED QDAKAKVVVA
AGVFFLVGGI LCLIPVCWSA NSVIKDFYNP TLSDAQKREL GASLFIGWCA SGLLLLGGAL
LCCQCPKNEG RAYSVKYSAP RSAPGAYV
