CLE19_ARATH
ID CLE19_ARATH Reviewed; 74 AA.
AC Q8W261;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 19 {ECO:0000303|PubMed:18034320};
DE Short=AtLLP1 {ECO:0000303|PubMed:12932329};
DE AltName: Full=Protein EMBRYO SURROUNDING REGION 19 {ECO:0000303|PubMed:16055633};
DE Contains:
DE RecName: Full=CLE19p {ECO:0000303|PubMed:18034320};
DE Flags: Precursor;
GN Name=CLE19 {ECO:0000303|PubMed:18034320};
GN Synonyms=ESR19 {ECO:0000303|PubMed:16055633},
GN LLP1 {ECO:0000303|PubMed:12932329};
GN OrderedLocusNames=At3g24225 {ECO:0000312|Araport:AT3G24225};
GN ORFNames=MUJ8 {ECO:0000312|EMBL:AB028621};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=14960359; DOI=10.1016/j.gene.2003.11.014;
RA Fiers M., Hause G., Boutilier K., Casamitjana-Martinez E., Weijers D.,
RA Offringa R., van der Geest L., van Lookeren Campagne M., Liu C.M.;
RT "Mis-expression of the CLV3/ESR-like gene CLE19 in Arabidopsis leads to a
RT consumption of root meristem.";
RL Gene 327:37-49(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11457943; DOI=10.1104/pp.126.3.939;
RA Cock J.M., McCormick S.;
RT "A large family of genes that share homology with CLAVATA3.";
RL Plant Physiol. 126:939-942(2001).
RN [6]
RP FUNCTION.
RX PubMed=12932329; DOI=10.1016/s0960-9822(03)00533-5;
RA Casamitjana-Martinez E., Hofhuis H.F., Xu J., Liu C.-M., Heidstra R.,
RA Scheres B.;
RT "Root-specific CLE19 overexpression and the sol1/2 suppressors implicate a
RT CLV-like pathway in the control of Arabidopsis root meristem maintenance.";
RL Curr. Biol. 13:1435-1441(2003).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=12602871; DOI=10.1023/a:1022038932376;
RA Sharma V.K., Ramirez J., Fletcher J.C.;
RT "The Arabidopsis CLV3-like (CLE) genes are expressed in diverse tissues and
RT encode secreted proteins.";
RL Plant Mol. Biol. 51:415-425(2003).
RN [8]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16055633; DOI=10.1105/tpc.105.034009;
RA Fiers M., Golemiec E., Xu J., van der Geest L., Heidstra R., Stiekema W.,
RA Liu C.-M.;
RT "The 14-amino acid CLV3, CLE19, and CLE40 peptides trigger consumption of
RT the root meristem in Arabidopsis through a CLAVATA2-dependent pathway.";
RL Plant Cell 17:2542-2553(2005).
RN [9]
RP FUNCTION.
RX PubMed=16407446; DOI=10.1104/pp.105.072678;
RA Ni J., Clark S.E.;
RT "Evidence for functional conservation, sufficiency, and proteolytic
RT processing of the CLAVATA3 CLE domain.";
RL Plant Physiol. 140:726-733(2006).
RN [10]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=16489133; DOI=10.1104/pp.105.075515;
RA Strabala T.J., O'donnell P.J., Smit A.-M., Ampomah-Dwamena C., Martin E.J.,
RA Netzler N., Nieuwenhuizen N.J., Quinn B.D., Foote H.C.C., Hudson K.R.;
RT "Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new
RT family members, correlate with tandem variations in the conserved
RT CLAVATA3/ESR domain.";
RL Plant Physiol. 140:1331-1344(2006).
RN [11]
RP FUNCTION.
RX PubMed=16902140; DOI=10.1126/science.1128436;
RA Ito Y., Nakanomyo I., Motose H., Iwamoto K., Sawa S., Dohmae N., Fukuda H.;
RT "Dodeca-CLE peptides as suppressors of plant stem cell differentiation.";
RL Science 313:842-845(2006).
RN [12]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [13]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [14]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
CC -!- FUNCTION: [CLE19p]: Extracellular signal peptide that regulates cell
CC fate. Represses root apical meristem maintenance.
CC {ECO:0000269|PubMed:12932329, ECO:0000269|PubMed:14960359,
CC ECO:0000269|PubMed:16055633, ECO:0000269|PubMed:16407446,
CC ECO:0000269|PubMed:16489133, ECO:0000269|PubMed:16902140}.
CC -!- SUBCELLULAR LOCATION: [CLE19p]: Secreted, extracellular space
CC {ECO:0000269|PubMed:16055633}.
CC -!- TISSUE SPECIFICITY: [CLE19p]: Mostly expressed in heart-shape embryos,
CC pollen and young flower buds, and, to a lower extent, in inflorescence,
CC leaves and roots. {ECO:0000269|PubMed:12602871,
CC ECO:0000269|PubMed:14960359}.
CC -!- PTM: [CLE19p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-68 enhances binding affinity of the CLE19p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
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DR EMBL; AF343657; AAL57177.1; -; mRNA.
DR EMBL; AB028621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002686; AEE76876.1; -; Genomic_DNA.
DR EMBL; BT026017; ABG25106.1; -; mRNA.
DR RefSeq; NP_683589.1; NM_148747.3.
DR AlphaFoldDB; Q8W261; -.
DR STRING; 3702.AT3G24225.1; -.
DR PaxDb; Q8W261; -.
DR EnsemblPlants; AT3G24225.1; AT3G24225.1; AT3G24225.
DR GeneID; 822009; -.
DR Gramene; AT3G24225.1; AT3G24225.1; AT3G24225.
DR KEGG; ath:AT3G24225; -.
DR Araport; AT3G24225; -.
DR TAIR; locus:504955740; AT3G24225.
DR HOGENOM; CLU_2691150_0_0_1; -.
DR InParanoid; Q8W261; -.
DR OMA; SMGTIAN; -.
DR OrthoDB; 1611801at2759; -.
DR PRO; PR:Q8W261; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8W261; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISM:TAIR.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; IPI:UniProtKB.
DR GO; GO:0001708; P:cell fate specification; IMP:TAIR.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
DR GO; GO:0010082; P:regulation of root meristem growth; IMP:TAIR.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..74
FT /note="CLAVATA3/ESR (CLE)-related protein 19"
FT /id="PRO_0000401267"
FT PEPTIDE 62..73
FT /note="CLE19p"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT /id="PRO_0000401268"
FT MOD_RES 65
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MOD_RES 68
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 68
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 74 AA; 8149 MW; 0E0AF623C0540AD9 CRC64;
MKIKGLMILA SSLLILAFIH QSESASMRSL LMNNGSYEEE EQVLKYDSMG TIANSSALDS
KRVIPTGPNP LHNR
