CLE1_ARATH
ID CLE1_ARATH Reviewed; 74 AA.
AC Q3ECD6;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 1 {ECO:0000303|PubMed:18034320};
DE Contains:
DE RecName: Full=CLE1p {ECO:0000303|PubMed:18034320};
DE Flags: Precursor;
GN Name=CLE1 {ECO:0000303|PubMed:18034320};
GN OrderedLocusNames=At1g73165 {ECO:0000312|Araport:AT1G73165};
GN ORFNames=F3N23 {ECO:0000312|EMBL:AC008017};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11457943; DOI=10.1104/pp.126.3.939;
RA Cock J.M., McCormick S.;
RT "A large family of genes that share homology with CLAVATA3.";
RL Plant Physiol. 126:939-942(2001).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12602871; DOI=10.1023/a:1022038932376;
RA Sharma V.K., Ramirez J., Fletcher J.C.;
RT "The Arabidopsis CLV3-like (CLE) genes are expressed in diverse tissues and
RT encode secreted proteins.";
RL Plant Mol. Biol. 51:415-425(2003).
RN [5]
RP FUNCTION, PROTEOLYTIC PROCESSING OF CLE1P, AND MUTAGENESIS OF ARG-63.
RX PubMed=16407446; DOI=10.1104/pp.105.072678;
RA Ni J., Clark S.E.;
RT "Evidence for functional conservation, sufficiency, and proteolytic
RT processing of the CLAVATA3 CLE domain.";
RL Plant Physiol. 140:726-733(2006).
RN [6]
RP GENE FAMILY.
RX PubMed=16489133; DOI=10.1104/pp.105.075515;
RA Strabala T.J., O'donnell P.J., Smit A.-M., Ampomah-Dwamena C., Martin E.J.,
RA Netzler N., Nieuwenhuizen N.J., Quinn B.D., Foote H.C.C., Hudson K.R.;
RT "Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new
RT family members, correlate with tandem variations in the conserved
RT CLAVATA3/ESR domain.";
RL Plant Physiol. 140:1331-1344(2006).
RN [7]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [8]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [9]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
CC -!- FUNCTION: [CLE1p]: Extracellular signal peptide that regulates cell
CC fate. {ECO:0000269|PubMed:16407446}.
CC -!- SUBCELLULAR LOCATION: [CLE1p]: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:O49519}.
CC -!- TISSUE SPECIFICITY: [CLE1p]: Mostly expressed in roots and seedlings,
CC and, to a lower extent, in stems and apex.
CC {ECO:0000269|PubMed:12602871}.
CC -!- PTM: [CLE1p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-69 enhances binding affinity of the CLE1p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
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DR EMBL; AC008017; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE35421.1; -; Genomic_DNA.
DR RefSeq; NP_001319370.1; NM_001334570.1.
DR AlphaFoldDB; Q3ECD6; -.
DR STRING; 3702.AT1G73165.1; -.
DR PaxDb; Q3ECD6; -.
DR PRIDE; Q3ECD6; -.
DR EnsemblPlants; AT1G73165.1; AT1G73165.1; AT1G73165.
DR GeneID; 28717420; -.
DR Gramene; AT1G73165.1; AT1G73165.1; AT1G73165.
DR KEGG; ath:AT1G73165; -.
DR Araport; AT1G73165; -.
DR TAIR; locus:504956162; AT1G73165.
DR eggNOG; ENOG502SFI1; Eukaryota.
DR HOGENOM; CLU_194792_1_0_1; -.
DR InParanoid; Q3ECD6; -.
DR OMA; PMFPNAD; -.
DR OrthoDB; 1639425at2759; -.
DR PhylomeDB; Q3ECD6; -.
DR PRO; PR:Q3ECD6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q3ECD6; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; IPI:UniProtKB.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
DR InterPro; IPR039817; CLE1.
DR InterPro; IPR039616; CLE1/3/4.
DR PANTHER; PTHR33869; PTHR33869; 1.
DR PANTHER; PTHR33869:SF15; PTHR33869:SF15; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Glycoprotein; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..74
FT /note="CLAVATA3/ESR (CLE)-related protein 1"
FT /id="PRO_0000401233"
FT PEPTIDE 63..74
FT /note="CLE1p"
FT /evidence="ECO:0000269|PubMed:16407446"
FT /id="PRO_0000401234"
FT MOD_RES 66
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MOD_RES 69
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 69
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MUTAGEN 63
FT /note="R->K,N: No impact on proteolysis."
FT /evidence="ECO:0000269|PubMed:16407446"
SQ SEQUENCE 74 AA; 8338 MW; D443188AFF3398C6 CRC64;
MANLKFLLCL FLICVSLSRS SASRPMFPNA DGIKRGRMMI EAEEVLKASM EKLMERGFNE
SMRLSPGGPD PRHH
