CLE22_ARATH
ID CLE22_ARATH Reviewed; 103 AA.
AC Q3E9I4;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 22 {ECO:0000303|PubMed:18034320};
DE Contains:
DE RecName: Full=CLE22p {ECO:0000303|PubMed:18034320};
DE Flags: Precursor;
GN Name=CLE22 {ECO:0000303|PubMed:18034320};
GN OrderedLocusNames=At5g12235 {ECO:0000312|Araport:AT5G12235};
GN ORFNames=MXC9 {ECO:0000312|EMBL:AB007727};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11457943; DOI=10.1104/pp.126.3.939;
RA Cock J.M., McCormick S.;
RT "A large family of genes that share homology with CLAVATA3.";
RL Plant Physiol. 126:939-942(2001).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12602871; DOI=10.1023/a:1022038932376;
RA Sharma V.K., Ramirez J., Fletcher J.C.;
RT "The Arabidopsis CLV3-like (CLE) genes are expressed in diverse tissues and
RT encode secreted proteins.";
RL Plant Mol. Biol. 51:415-425(2003).
RN [5]
RP FUNCTION.
RX PubMed=16407446; DOI=10.1104/pp.105.072678;
RA Ni J., Clark S.E.;
RT "Evidence for functional conservation, sufficiency, and proteolytic
RT processing of the CLAVATA3 CLE domain.";
RL Plant Physiol. 140:726-733(2006).
RN [6]
RP GENE FAMILY.
RX PubMed=16489133; DOI=10.1104/pp.105.075515;
RA Strabala T.J., O'donnell P.J., Smit A.-M., Ampomah-Dwamena C., Martin E.J.,
RA Netzler N., Nieuwenhuizen N.J., Quinn B.D., Foote H.C.C., Hudson K.R.;
RT "Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new
RT family members, correlate with tandem variations in the conserved
RT CLAVATA3/ESR domain.";
RL Plant Physiol. 140:1331-1344(2006).
RN [7]
RP FUNCTION.
RX PubMed=16902140; DOI=10.1126/science.1128436;
RA Ito Y., Nakanomyo I., Motose H., Iwamoto K., Sawa S., Dohmae N., Fukuda H.;
RT "Dodeca-CLE peptides as suppressors of plant stem cell differentiation.";
RL Science 313:842-845(2006).
RN [8]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [9]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [10]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
CC -!- FUNCTION: [CLE22p]: Extracellular signal peptide that regulates cell
CC fate. Represses root apical meristem maintenance.
CC {ECO:0000269|PubMed:16407446, ECO:0000269|PubMed:16902140}.
CC -!- SUBCELLULAR LOCATION: [CLE22p]: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:O49519}.
CC -!- TISSUE SPECIFICITY: [CLE22p]: Mostly expressed in stems and apex, and,
CC to a lower extent, in seedlings, leaves, flowers and siliques.
CC {ECO:0000269|PubMed:12602871}.
CC -!- PTM: [CLE22p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-97 enhances binding affinity of the CLE22p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB007727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED91779.1; -; Genomic_DNA.
DR RefSeq; NP_680162.1; NM_147857.2.
DR AlphaFoldDB; Q3E9I4; -.
DR SMR; Q3E9I4; -.
DR STRING; 3702.AT5G12235.1; -.
DR PaxDb; Q3E9I4; -.
DR PRIDE; Q3E9I4; -.
DR EnsemblPlants; AT5G12235.1; AT5G12235.1; AT5G12235.
DR GeneID; 831098; -.
DR Gramene; AT5G12235.1; AT5G12235.1; AT5G12235.
DR KEGG; ath:AT5G12235; -.
DR Araport; AT5G12235; -.
DR TAIR; locus:504954845; AT5G12235.
DR HOGENOM; CLU_162925_0_0_1; -.
DR InParanoid; Q3E9I4; -.
DR OMA; NIHHHST; -.
DR OrthoDB; 1537388at2759; -.
DR PhylomeDB; Q3E9I4; -.
DR PRO; PR:Q3E9I4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q3E9I4; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; IPI:UniProtKB.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
DR GO; GO:0010078; P:maintenance of root meristem identity; IMP:TAIR.
DR GO; GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.
DR GO; GO:0048364; P:root development; IMP:TAIR.
DR InterPro; IPR033249; CLE_plant.
DR PANTHER; PTHR34545; PTHR34545; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..103
FT /note="CLAVATA3/ESR (CLE)-related protein 22"
FT /id="PRO_0000401273"
FT PEPTIDE 91..102
FT /note="CLE22p"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT /id="PRO_0000401274"
FT REGION 37..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 97
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 97
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 103 AA; 11510 MW; EFF86F71AF561D44 CRC64;
MGNYYSRRKS RKHITTVALI ILLLLLFLFL YAKASSSSPN IHHHSTHGSL KKSGNLDPKL
HDLDSNAASS RGSKYTNYEG GGEDVFEDGK RRVFTGPNPL HNR
