ACK1_YEAST
ID ACK1_YEAST Reviewed; 623 AA.
AC Q07622; D6VRF1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Activator of C kinase protein 1;
GN Name=ACK1; OrderedLocusNames=YDL203C; ORFNames=D1066;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9046097;
RX DOI=10.1002/(sici)1097-0061(199702)13:2<163::aid-yea54>3.0.co;2-4;
RA Bahr A., Moeller-Rieker S., Hankeln T., Kraemer C., Protin U.,
RA Schmidt E.R.;
RT "The nucleotide sequence of a 39 kb segment of yeast chromosome IV: 12 new
RT open reading frames, nine known genes and one gene for Gly-tRNA.";
RL Yeast 13:163-169(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-184, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC STRAIN=SUB592;
RX PubMed=12872131; DOI=10.1038/nbt849;
RA Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D., Marsischky G.,
RA Roelofs J., Finley D., Gygi S.P.;
RT "A proteomics approach to understanding protein ubiquitination.";
RL Nat. Biotechnol. 21:921-926(2003).
RN [6]
RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-184 AND LYS-191, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22106047; DOI=10.1002/pmic.201100166;
RA Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.;
RT "Sites of ubiquitin attachment in Saccharomyces cerevisiae.";
RL Proteomics 12:236-240(2012).
CC -!- INTERACTION:
CC Q07622; P39940: RSP5; NbExp=3; IntAct=EBI-38674, EBI-16219;
CC -!- MISCELLANEOUS: Present with 98 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X99000; CAA67465.1; -; Genomic_DNA.
DR EMBL; Z74251; CAA98781.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11661.1; -; Genomic_DNA.
DR PIR; S67762; S67762.
DR RefSeq; NP_010078.1; NM_001180263.1.
DR AlphaFoldDB; Q07622; -.
DR SMR; Q07622; -.
DR BioGRID; 31843; 201.
DR DIP; DIP-1805N; -.
DR IntAct; Q07622; 12.
DR MINT; Q07622; -.
DR STRING; 4932.YDL203C; -.
DR iPTMnet; Q07622; -.
DR MaxQB; Q07622; -.
DR PaxDb; Q07622; -.
DR PRIDE; Q07622; -.
DR EnsemblFungi; YDL203C_mRNA; YDL203C; YDL203C.
DR GeneID; 851324; -.
DR KEGG; sce:YDL203C; -.
DR SGD; S000002362; ACK1.
DR VEuPathDB; FungiDB:YDL203C; -.
DR eggNOG; KOG1550; Eukaryota.
DR HOGENOM; CLU_026113_1_0_1; -.
DR InParanoid; Q07622; -.
DR OMA; MKWCETL; -.
DR BioCyc; YEAST:G3O-29586-MON; -.
DR PRO; PR:Q07622; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q07622; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0031505; P:fungal-type cell wall organization; IMP:SGD.
DR GO; GO:0009967; P:positive regulation of signal transduction; IMP:SGD.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF08238; Sel1; 7.
DR SMART; SM00671; SEL1; 7.
PE 1: Evidence at protein level;
KW Isopeptide bond; Reference proteome; Repeat; Ubl conjugation.
FT CHAIN 1..623
FT /note="Activator of C kinase protein 1"
FT /id="PRO_0000242166"
FT REPEAT 318..361
FT /note="Sel1-like 1"
FT REPEAT 408..444
FT /note="Sel1-like 2"
FT REPEAT 495..531
FT /note="Sel1-like 3"
FT REPEAT 576..611
FT /note="Sel1-like 4"
FT REGION 141..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 184
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0007744|PubMed:22106047"
FT CROSSLNK 191
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0007744|PubMed:22106047"
SQ SEQUENCE 623 AA; 69371 MW; 5CBB9D907443EC2E CRC64;
MVNQGQPQPN LYDKHINMFP PARARESSHK LGNANSDRHG LPAQNIVPAP YPVDDSIVEL
TPAIPFTSPS SSSSLSLPLS ALNFTDGNAD GGQLGTPVTI NSNNGMDIFN SKPTGEIGYA
NNGTNSTGSR YELPFNFSST KESLGSPAVQ DASISSGNRI SESVRDNSAP PPYEESESRI
LQEKVYRTEE KAPIRPLNNN PVPPQKINQP PTGSAKTDDN GSSGGEDKLS SYSPEALAFY
QVYKKTITDS SKFTPEIQMQ WCETLLTYAF NEDFISQYNI NAEKLKRSLK PEEMLKNQKV
ILEHSFKVLT KLITLKWPPA MYLMGTLYSH QPYLPIKNKN IVIKNDEKAL EYYCKAAKLN
NSDACYRAGV CFEYQRGTSS LDPSPTKEQC IKKAFQYYQH GAEVCSNSAC MYKLGMSHLY
GLNMQKTDVL LAIKWFDKAA QKGDSPQTLY ELGKIYEFSV LPPEIQNLLF ANGIRKDSQL
AIKYYQQCAK DFEYPLAQWK LGNCYEFGDL GLPVVAKKSI YWYSKAAAAQ PKGNPMAMLS
LSGWYLTGAP NILKPNNKEA FNWALKSSKC SDGKLARTEF ALGFYYEKGV GCEVDLDLAK
QYYQRAARMG FRKAVDALRS LTN
