CLE26_ARATH
ID CLE26_ARATH Reviewed; 118 AA.
AC O04547; A0MEF4; B3H6F4;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 26 {ECO:0000303|PubMed:16489133};
DE Contains:
DE RecName: Full=CLE26p {ECO:0000303|PubMed:16489133};
DE Flags: Precursor;
GN Name=CLE26 {ECO:0000303|PubMed:16489133};
GN OrderedLocusNames=At1g69970 {ECO:0000312|Araport:AT1G69970};
GN ORFNames=F20P5.29 {ECO:0000312|EMBL:AAB61115.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11457943; DOI=10.1104/pp.126.3.939;
RA Cock J.M., McCormick S.;
RT "A large family of genes that share homology with CLAVATA3.";
RL Plant Physiol. 126:939-942(2001).
RN [5]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=16489133; DOI=10.1104/pp.105.075515;
RA Strabala T.J., O'donnell P.J., Smit A.-M., Ampomah-Dwamena C., Martin E.J.,
RA Netzler N., Nieuwenhuizen N.J., Quinn B.D., Foote H.C.C., Hudson K.R.;
RT "Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new
RT family members, correlate with tandem variations in the conserved
RT CLAVATA3/ESR domain.";
RL Plant Physiol. 140:1331-1344(2006).
RN [6]
RP FUNCTION.
RX PubMed=16902140; DOI=10.1126/science.1128436;
RA Ito Y., Nakanomyo I., Motose H., Iwamoto K., Sawa S., Dohmae N., Fukuda H.;
RT "Dodeca-CLE peptides as suppressors of plant stem cell differentiation.";
RL Science 313:842-845(2006).
RN [7]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [8]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [9]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
RN [10]
RP FUNCTION.
RC STRAIN=cv. Columbia;
RX PubMed=28607033; DOI=10.15252/embr.201643535;
RA Hazak O., Brandt B., Cattaneo P., Santiago J., Rodriguez-Villalon A.,
RA Hothorn M., Hardtke C.S.;
RT "Perception of root-active CLE peptides requires CORYNE function in the
RT phloem vasculature.";
RL EMBO Rep. 18:1367-1381(2017).
CC -!- FUNCTION: [CLE26p]: Extracellular signal peptide that regulates cell
CC fate. Represses root apical meristem maintenance. Regulates the
CC transition of protophloem cells from proliferation to differentiation,
CC thus impinging on postembryonic growth capacity of the root meristem;
CC this signaling pathway requires CRN and CLV2 (PubMed:28607033).
CC {ECO:0000269|PubMed:16489133, ECO:0000269|PubMed:16902140,
CC ECO:0000269|PubMed:28607033}.
CC -!- SUBCELLULAR LOCATION: [CLE26p]: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:O49519}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O04547-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O04547-2; Sequence=VSP_040150, VSP_040151;
CC -!- PTM: [CLE26p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-84 enhances binding affinity of the CLE26p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28459.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC002062; AAB61115.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35003.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35004.1; -; Genomic_DNA.
DR EMBL; DQ446415; ABE65759.1; -; mRNA.
DR EMBL; DQ652924; ABK28459.1; ALT_SEQ; mRNA.
DR PIR; C96722; C96722.
DR RefSeq; NP_001117575.1; NM_001124103.2. [O04547-2]
DR RefSeq; NP_177155.1; NM_105666.2. [O04547-1]
DR AlphaFoldDB; O04547; -.
DR SMR; O04547; -.
DR BioGRID; 28555; 22.
DR IntAct; O04547; 21.
DR STRING; 3702.AT1G69970.1; -.
DR PaxDb; O04547; -.
DR PRIDE; O04547; -.
DR EnsemblPlants; AT1G69970.1; AT1G69970.1; AT1G69970. [O04547-1]
DR EnsemblPlants; AT1G69970.2; AT1G69970.2; AT1G69970. [O04547-2]
DR GeneID; 843334; -.
DR Gramene; AT1G69970.1; AT1G69970.1; AT1G69970. [O04547-1]
DR Gramene; AT1G69970.2; AT1G69970.2; AT1G69970. [O04547-2]
DR KEGG; ath:AT1G69970; -.
DR Araport; AT1G69970; -.
DR TAIR; locus:2020683; AT1G69970.
DR InParanoid; O04547; -.
DR OrthoDB; 1555873at2759; -.
DR PhylomeDB; O04547; -.
DR PRO; PR:O04547; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O04547; baseline and differential.
DR Genevisible; O04547; AT.
DR GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; IPI:UniProtKB.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
DR GO; GO:0010078; P:maintenance of root meristem identity; IDA:UniProtKB.
DR GO; GO:0010088; P:phloem development; IDA:UniProtKB.
DR GO; GO:0045595; P:regulation of cell differentiation; IDA:UniProtKB.
DR InterPro; IPR039316; CLE25/26.
DR PANTHER; PTHR34277; PTHR34277; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Developmental protein; Differentiation; Glycoprotein;
KW Hydroxylation; Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..118
FT /note="CLAVATA3/ESR (CLE)-related protein 26"
FT /id="PRO_0000401277"
FT PEPTIDE 78..89
FT /note="CLE26p"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT /id="PRO_0000401278"
FT MOD_RES 81
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MOD_RES 84
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 84
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT VAR_SEQ 91..102
FT /note="FLLLSRFILSLL -> RAGNSRRPPGRA (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_040150"
FT VAR_SEQ 103..118
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_040151"
SQ SEQUENCE 118 AA; 13631 MW; ADC06866731CD468 CRC64;
MRNNHSLRLQ LWFRTLFTVG VVTLLMIDAF VLQNNKEDDK TKEITTAVNM NNSDAKEIQQ
ELEDGSRNDD LSYVASKRKV PRGPDPIHNR FLLLSRFILS LLTNPYPYLH ICVLDVSV
