CLE27_ARATH
ID CLE27_ARATH Reviewed; 91 AA.
AC Q9LUA1; Q8LC08;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 27 {ECO:0000303|PubMed:18034320};
DE Contains:
DE RecName: Full=CLE27p {ECO:0000303|PubMed:18034320};
DE Flags: Precursor;
GN Name=CLE27 {ECO:0000303|PubMed:18034320};
GN OrderedLocusNames=At3g25905 {ECO:0000312|Araport:AT3G25905};
GN ORFNames=MPE11 {ECO:0000312|EMBL:BAB01053.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=19690829; DOI=10.1007/s00122-009-1127-x;
RA Banaei Moghaddam A.M., Fuchs J., Czauderna T., Houben A., Mette M.F.;
RT "Intraspecific hybrids of Arabidopsis thaliana revealed no gross
RT alterations in endopolyploidy, DNA methylation, histone modifications and
RT transcript levels.";
RL Theor. Appl. Genet. 120:215-226(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11457943; DOI=10.1104/pp.126.3.939;
RA Cock J.M., McCormick S.;
RT "A large family of genes that share homology with CLAVATA3.";
RL Plant Physiol. 126:939-942(2001).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=12602871; DOI=10.1023/a:1022038932376;
RA Sharma V.K., Ramirez J., Fletcher J.C.;
RT "The Arabidopsis CLV3-like (CLE) genes are expressed in diverse tissues and
RT encode secreted proteins.";
RL Plant Mol. Biol. 51:415-425(2003).
RN [8]
RP GENE FAMILY.
RX PubMed=16489133; DOI=10.1104/pp.105.075515;
RA Strabala T.J., O'donnell P.J., Smit A.-M., Ampomah-Dwamena C., Martin E.J.,
RA Netzler N., Nieuwenhuizen N.J., Quinn B.D., Foote H.C.C., Hudson K.R.;
RT "Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new
RT family members, correlate with tandem variations in the conserved
RT CLAVATA3/ESR domain.";
RL Plant Physiol. 140:1331-1344(2006).
RN [9]
RP FUNCTION.
RX PubMed=16902140; DOI=10.1126/science.1128436;
RA Ito Y., Nakanomyo I., Motose H., Iwamoto K., Sawa S., Dohmae N., Fukuda H.;
RT "Dodeca-CLE peptides as suppressors of plant stem cell differentiation.";
RL Science 313:842-845(2006).
RN [10]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [11]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [12]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
CC -!- FUNCTION: [CLE27p]: Extracellular signal peptide that regulates cell
CC fate. Represses root apical meristem maintenance.
CC {ECO:0000269|PubMed:16902140}.
CC -!- SUBCELLULAR LOCATION: [CLE27p]: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:O49519}.
CC -!- TISSUE SPECIFICITY: [CLE27p]: Mostly expressed in apex, and, to a lower
CC extent, in roots, leaves, flowers and siliques.
CC {ECO:0000269|PubMed:12602871}.
CC -!- PTM: [CLE27p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-86 enhances binding affinity of the CLE27p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM63919.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; FJ899139; ACT82820.1; -; Genomic_DNA.
DR EMBL; AB023041; BAB01053.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77089.1; -; Genomic_DNA.
DR EMBL; BT028939; ABI49486.1; -; mRNA.
DR EMBL; AY086873; AAM63919.1; ALT_INIT; mRNA.
DR RefSeq; NP_566783.1; NM_113494.2.
DR AlphaFoldDB; Q9LUA1; -.
DR SMR; Q9LUA1; -.
DR STRING; 3702.AT3G25905.1; -.
DR iPTMnet; Q9LUA1; -.
DR PaxDb; Q9LUA1; -.
DR PRIDE; Q9LUA1; -.
DR EnsemblPlants; AT3G25905.1; AT3G25905.1; AT3G25905.
DR GeneID; 822187; -.
DR Gramene; AT3G25905.1; AT3G25905.1; AT3G25905.
DR KEGG; ath:AT3G25905; -.
DR Araport; AT3G25905; -.
DR TAIR; locus:505006378; AT3G25905.
DR HOGENOM; CLU_2593092_0_0_1; -.
DR InParanoid; Q9LUA1; -.
DR OMA; THAREWR; -.
DR OrthoDB; 1603337at2759; -.
DR PhylomeDB; Q9LUA1; -.
DR PRO; PR:Q9LUA1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LUA1; baseline and differential.
DR Genevisible; Q9LUA1; AT.
DR GO; GO:0048046; C:apoplast; ISM:TAIR.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
DR InterPro; IPR040274; CLE27/CLE43.
DR PANTHER; PTHR37184; PTHR37184; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..91
FT /note="CLAVATA3/ESR (CLE)-related protein 27"
FT /id="PRO_0000401279"
FT PEPTIDE 80..91
FT /note="CLE27p"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT /id="PRO_0000401280"
FT MOD_RES 83
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MOD_RES 86
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 86
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 91 AA; 10286 MW; 5B8733BDCEDFDEF1 CRC64;
MTHAREWRSS LTTTLLMVIL LSYMLHLFCV YSRVGAIRIF PETPASGKRQ EEDLMKKYFG
AGKFPPVDSF VGKGISESKR IVPSCPDPLH N
