ID   CLE2_CONAW              Reviewed;         122 AA.
AC   A0A3G1VU73;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   13-FEB-2019, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Conotoxin flf14.2 {ECO:0000303|PubMed:30040981};
DE   Flags: Precursor;
OS   Conus anabathrum floridanus (Florida cone) (Conus floridanus floridensis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dauciconus.
OX   NCBI_TaxID=1520082;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=30040981; DOI=10.1016/j.peptides.2018.06.002;
RA   Moeller C., Dovell S., Melaun C., Mari F.;
RT   "Definition of the R-superfamily of conotoxins: structural convergence of
RT   helix-loop-helix peptidic scaffolds.";
RL   Peptides 107:75-82(2018).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:30040981}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30040981}.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin R superfamily. {ECO:0000305}.
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DR   EMBL; MH750031; AYK27404.1; -; mRNA.
DR   AlphaFoldDB; A0A3G1VU73; -.
DR   SMR; A0A3G1VU73; -.
DR   ConoServer; 8489; FlfXIVB precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..96
FT                   /evidence="ECO:0000305|PubMed:30040981"
FT                   /id="PRO_0000446990"
FT   PEPTIDE         96..122
FT                   /note="Conotoxin flf14.2"
FT                   /evidence="ECO:0000305|PubMed:30040981"
FT                   /id="PRO_0000446991"
FT   REGION          53..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        101..121
FT                   /evidence="ECO:0000250|UniProtKB:P84707"
FT   DISULFID        105..117
FT                   /evidence="ECO:0000250|UniProtKB:P84707"
SQ   SEQUENCE   122 AA;  14015 MW;  34B3BA503821369C CRC64;
     MGFRVLVLIV MVTTSALPFT FSEESGRSPF RPALRSEEAQ ALRHGLTLLL ARRADGQPSD
     MRQPEMRRPE MRRPEVRRPE VRQPEFAESP VGQKRWDVND CIHFCLIGVV GRSYTECHTM
     CT