CLE42_ARATH
ID CLE42_ARATH Reviewed; 88 AA.
AC Q6IWB2;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 42 {ECO:0000303|PubMed:18034320};
DE Contains:
DE RecName: Full=CLE42p {ECO:0000303|PubMed:18034320};
DE Flags: Precursor;
GN Name=CLE42 {ECO:0000303|PubMed:18034320};
GN OrderedLocusNames=At2g34925 {ECO:0000312|Araport:AT2G34925};
GN ORFNames=F19I3 {ECO:0000312|EMBL:AC004238};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, AND GENE
RP FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=16489133; DOI=10.1104/pp.105.075515;
RA Strabala T.J., O'donnell P.J., Smit A.-M., Ampomah-Dwamena C., Martin E.J.,
RA Netzler N., Nieuwenhuizen N.J., Quinn B.D., Foote H.C.C., Hudson K.R.;
RT "Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new
RT family members, correlate with tandem variations in the conserved
RT CLAVATA3/ESR domain.";
RL Plant Physiol. 140:1331-1344(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION.
RX PubMed=16902140; DOI=10.1126/science.1128436;
RA Ito Y., Nakanomyo I., Motose H., Iwamoto K., Sawa S., Dohmae N., Fukuda H.;
RT "Dodeca-CLE peptides as suppressors of plant stem cell differentiation.";
RL Science 313:842-845(2006).
RN [5]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [6]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [7]
RP FUNCTION.
RX PubMed=19011104; DOI=10.1073/pnas.0809395105;
RA Whitford R., Fernandez A., De Groodt R., Ortega E., Hilson P.;
RT "Plant CLE peptides from two distinct functional classes synergistically
RT induce division of vascular cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:18625-18630(2008).
RN [8]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
CC -!- FUNCTION: [CLE42p]: Extracellular signal peptide that regulates cell
CC fate. Represses tracheary element differentiation but promotes the
CC formation of procambial cells. {ECO:0000269|PubMed:16489133,
CC ECO:0000269|PubMed:16902140, ECO:0000269|PubMed:19011104}.
CC -!- SUBCELLULAR LOCATION: [CLE42p]: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:O49519}.
CC -!- TISSUE SPECIFICITY: [CLE42p]: Expressed at low levels in seedlings,
CC roots and inflorescence. {ECO:0000269|PubMed:16489133}.
CC -!- PTM: [CLE42p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-82 enhances binding affinity of the CLE42p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
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DR EMBL; AY618655; AAT36741.1; -; Genomic_DNA.
DR EMBL; AC004238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002685; AEC09040.1; -; Genomic_DNA.
DR RefSeq; NP_001318356.1; NM_001336535.1.
DR AlphaFoldDB; Q6IWB2; -.
DR STRING; 3702.AT2G34925.1; -.
DR PaxDb; Q6IWB2; -.
DR PRIDE; Q6IWB2; -.
DR EnsemblPlants; AT2G34925.1; AT2G34925.1; AT2G34925.
DR GeneID; 28718327; -.
DR Gramene; AT2G34925.1; AT2G34925.1; AT2G34925.
DR KEGG; ath:AT2G34925; -.
DR Araport; AT2G34925; -.
DR TAIR; locus:4010713679; AT2G34925.
DR HOGENOM; CLU_190199_0_0_1; -.
DR InParanoid; Q6IWB2; -.
DR OMA; IGANEHG; -.
DR OrthoDB; 1623494at2759; -.
DR PhylomeDB; Q6IWB2; -.
DR PRO; PR:Q6IWB2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q6IWB2; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; IPI:UniProtKB.
DR GO; GO:0090506; P:axillary shoot meristem initiation; IDA:TAIR.
DR GO; GO:0051301; P:cell division; IMP:TAIR.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
DR GO; GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.
DR GO; GO:0010223; P:secondary shoot formation; IMP:TAIR.
DR GO; GO:0010089; P:xylem development; IEA:InterPro.
DR InterPro; IPR037495; CLE41/42/44.
DR PANTHER; PTHR35301; PTHR35301; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..88
FT /note="CLAVATA3/ESR (CLE)-related protein 42"
FT /evidence="ECO:0000255"
FT /id="PRO_5000093474"
FT PEPTIDE 76..87
FT /note="CLE42p"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT /id="PRO_0000401285"
FT REGION 69..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 79
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MOD_RES 82
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 82
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 88 AA; 10106 MW; 7AFDDF38F92E1229 CRC64;
MRSPHITISL VFLFFLFLII QTHQRTIDQT HQIGSNVQHV SDMAVTSPEG KRRERFRVRR
PMTTWLKGKM IGANEHGVPS GPNPISNR
