CLE46_ARATH
ID CLE46_ARATH Reviewed; 76 AA.
AC Q8LDN4; A0MFQ6;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 46 {ECO:0000303|PubMed:18034320};
DE Contains:
DE RecName: Full=CLE46p {ECO:0000303|PubMed:18034320};
DE Flags: Precursor;
GN Name=CLE46 {ECO:0000303|PubMed:18034320};
GN OrderedLocusNames=At5g59305 {ECO:0000312|Araport:AT5G59305};
GN ORFNames=MNC17 {ECO:0000312|EMBL:AB016890};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Sawa S., Fukuda H.;
RT "An analysis of CLE genes of Arabidopsis.";
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF Clones.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [8]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [9]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
CC -!- FUNCTION: [CLE46p]: Extracellular signal peptide that regulates cell
CC fate. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [CLE46p]: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:O49519}.
CC -!- PTM: [CLE46p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-64 enhances binding affinity of the CLE46p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABK28767.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB241063; BAE94179.1; -; mRNA.
DR EMBL; AB016890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED97169.1; -; Genomic_DNA.
DR EMBL; DQ447094; ABE66263.1; -; mRNA.
DR EMBL; DQ653382; ABK28767.1; ALT_SEQ; mRNA.
DR EMBL; BT026400; ABH04507.1; -; mRNA.
DR EMBL; AY085895; AAM63107.1; -; mRNA.
DR RefSeq; NP_568903.1; NM_125321.3.
DR AlphaFoldDB; Q8LDN4; -.
DR STRING; 3702.AT5G59305.1; -.
DR PaxDb; Q8LDN4; -.
DR PRIDE; Q8LDN4; -.
DR EnsemblPlants; AT5G59305.1; AT5G59305.1; AT5G59305.
DR GeneID; 836049; -.
DR Gramene; AT5G59305.1; AT5G59305.1; AT5G59305.
DR KEGG; ath:AT5G59305; -.
DR Araport; AT5G59305; -.
DR TAIR; locus:505006704; AT5G59305.
DR HOGENOM; CLU_174348_0_0_1; -.
DR InParanoid; Q8LDN4; -.
DR OMA; EEKKWHK; -.
DR OrthoDB; 1648619at2759; -.
DR PhylomeDB; Q8LDN4; -.
DR PRO; PR:Q8LDN4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8LDN4; baseline and differential.
DR Genevisible; Q8LDN4; AT.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
PE 3: Inferred from homology;
KW Developmental protein; Differentiation; Glycoprotein; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..76
FT /note="CLAVATA3/ESR (CLE)-related protein 46"
FT /id="PRO_0000401290"
FT PEPTIDE 58..69
FT /note="CLE46p"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT /id="PRO_0000401291"
FT REGION 53..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 61
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MOD_RES 64
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 64
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 76 AA; 8850 MW; 8DDD432B01A6BFBF CRC64;
MRRHDIIIKL LLLMCLLLSR FVTRECQEVH FKIGPAKIIA KPNNARVMPT WGEEKKWHKH
PSGPNPTGNR HPPVKH
