CLE4_ARATH
ID CLE4_ARATH Reviewed; 80 AA.
AC Q8S8N0;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 4 {ECO:0000303|PubMed:18034320};
DE Contains:
DE RecName: Full=CLE4p {ECO:0000303|PubMed:18034320};
DE Flags: Precursor;
GN Name=CLE4 {ECO:0000303|PubMed:18034320}; Synonyms=CLE6;
GN OrderedLocusNames=At2g31081 {ECO:0000312|Araport:AT2G31081};
GN ORFNames=T16B12 {ECO:0000312|EMBL:AAM15029.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11457943; DOI=10.1104/pp.126.3.939;
RA Cock J.M., McCormick S.;
RT "A large family of genes that share homology with CLAVATA3.";
RL Plant Physiol. 126:939-942(2001).
RN [5]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=12602871; DOI=10.1023/a:1022038932376;
RA Sharma V.K., Ramirez J., Fletcher J.C.;
RT "The Arabidopsis CLV3-like (CLE) genes are expressed in diverse tissues and
RT encode secreted proteins.";
RL Plant Mol. Biol. 51:415-425(2003).
RN [6]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=16489133; DOI=10.1104/pp.105.075515;
RA Strabala T.J., O'donnell P.J., Smit A.-M., Ampomah-Dwamena C., Martin E.J.,
RA Netzler N., Nieuwenhuizen N.J., Quinn B.D., Foote H.C.C., Hudson K.R.;
RT "Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new
RT family members, correlate with tandem variations in the conserved
RT CLAVATA3/ESR domain.";
RL Plant Physiol. 140:1331-1344(2006).
RN [7]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [8]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [9]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
CC -!- FUNCTION: [CLE4p]: Extracellular signal peptide that regulates cell
CC fate. {ECO:0000269|PubMed:16489133}.
CC -!- SUBCELLULAR LOCATION: [CLE4p]: Secreted, extracellular space
CC {ECO:0000269|PubMed:12602871}.
CC -!- TISSUE SPECIFICITY: [CLE4p]: Expressed in roots and seedlings.
CC {ECO:0000269|PubMed:12602871}.
CC -!- PTM: [CLE4p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-75 enhances binding affinity of the CLE4p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
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DR EMBL; AC005311; AAM15029.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08488.1; -; Genomic_DNA.
DR EMBL; BT012587; AAT06406.1; -; mRNA.
DR EMBL; BT015094; AAT71966.1; -; mRNA.
DR RefSeq; NP_850157.1; NM_179826.2.
DR AlphaFoldDB; Q8S8N0; -.
DR SMR; Q8S8N0; -.
DR STRING; 3702.AT2G31081.1; -.
DR PaxDb; Q8S8N0; -.
DR PRIDE; Q8S8N0; -.
DR EnsemblPlants; AT2G31081.1; AT2G31081.1; AT2G31081.
DR GeneID; 817661; -.
DR Gramene; AT2G31081.1; AT2G31081.1; AT2G31081.
DR KEGG; ath:AT2G31081; -.
DR Araport; AT2G31081; -.
DR TAIR; locus:504955980; AT2G31081.
DR eggNOG; ENOG502SYF4; Eukaryota.
DR HOGENOM; CLU_194792_0_0_1; -.
DR OMA; MASFKLW; -.
DR OrthoDB; 1639425at2759; -.
DR PhylomeDB; Q8S8N0; -.
DR PRO; PR:Q8S8N0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8S8N0; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISM:TAIR.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; IBA:GO_Central.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
DR GO; GO:0010075; P:regulation of meristem growth; IMP:TAIR.
DR InterPro; IPR039616; CLE1/3/4.
DR PANTHER; PTHR33869; PTHR33869; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..80
FT /note="CLAVATA3/ESR (CLE)-related protein 4"
FT /id="PRO_0000401239"
FT PEPTIDE 69..80
FT /note="CLE4p"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT /id="PRO_0000401240"
FT REGION 55..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 72
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MOD_RES 75
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 75
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 80 AA; 9052 MW; CEF12A4827903735 CRC64;
MASFKLWVCL ILLLLEFSVH QCRPLVAEES PSDSGNIRKI MRELLKRSEE LKVRSKDGQT
VLGTLDSKRL SPGGPDPRHH
