ID   CLE4_CONVL              Reviewed;         112 AA.
AC   A0A3G1VU78;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   13-FEB-2019, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Conotoxin vil14.4 {ECO:0000303|PubMed:30040981};
DE   Flags: Precursor;
OS   Conus villepinii (Villepin's cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dauciconus.
OX   NCBI_TaxID=257347;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=30040981; DOI=10.1016/j.peptides.2018.06.002;
RA   Moeller C., Dovell S., Melaun C., Mari F.;
RT   "Definition of the R-superfamily of conotoxins: structural convergence of
RT   helix-loop-helix peptidic scaffolds.";
RL   Peptides 107:75-82(2018).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:30040981}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30040981}.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin R superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MH750035; AYK27408.1; -; mRNA.
DR   AlphaFoldDB; A0A3G1VU78; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Potassium channel impairing toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..85
FT                   /evidence="ECO:0000305|PubMed:30040981"
FT                   /id="PRO_0000446996"
FT   PEPTIDE         86..112
FT                   /note="Conotoxin vil14.4"
FT                   /evidence="ECO:0000305|PubMed:30040981"
FT                   /id="PRO_0000446997"
FT   DISULFID        91..111
FT                   /evidence="ECO:0000250|UniProtKB:P84704"
FT   DISULFID        95..107
FT                   /evidence="ECO:0000250|UniProtKB:P84704"
SQ   SEQUENCE   112 AA;  12866 MW;  32F493F21E0C030C CRC64;
     MGFRVLVLVV MATTSALPFT FFEEPGRSPF RPALRSEEAQ ALRHGLTLLL ARRADGQPPD
     MRQPEMRRPE VRQLEFAELS VGQRRWDVDQ CMYYCLTGVV GYSYTECQTM CT