CLE5_ARATH
ID CLE5_ARATH Reviewed; 81 AA.
AC Q8S8N2;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 5 {ECO:0000303|PubMed:18034320};
DE Contains:
DE RecName: Full=CLE5p {ECO:0000303|PubMed:18034320};
DE Flags: Precursor;
GN Name=CLE5 {ECO:0000303|PubMed:18034320}; Synonyms=CLE7;
GN OrderedLocusNames=At2g31083 {ECO:0000312|Araport:AT2G31083};
GN ORFNames=T16B12 {ECO:0000312|EMBL:AAM15027.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=16244158; DOI=10.1104/pp.105.063479;
RA Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT reveals numerous transcript variants.";
RL Plant Physiol. 139:1323-1337(2005).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11457943; DOI=10.1104/pp.126.3.939;
RA Cock J.M., McCormick S.;
RT "A large family of genes that share homology with CLAVATA3.";
RL Plant Physiol. 126:939-942(2001).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=12602871; DOI=10.1023/a:1022038932376;
RA Sharma V.K., Ramirez J., Fletcher J.C.;
RT "The Arabidopsis CLV3-like (CLE) genes are expressed in diverse tissues and
RT encode secreted proteins.";
RL Plant Mol. Biol. 51:415-425(2003).
RN [6]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=16489133; DOI=10.1104/pp.105.075515;
RA Strabala T.J., O'donnell P.J., Smit A.-M., Ampomah-Dwamena C., Martin E.J.,
RA Netzler N., Nieuwenhuizen N.J., Quinn B.D., Foote H.C.C., Hudson K.R.;
RT "Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new
RT family members, correlate with tandem variations in the conserved
RT CLAVATA3/ESR domain.";
RL Plant Physiol. 140:1331-1344(2006).
RN [7]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [8]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [9]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
CC -!- FUNCTION: [CLE5p]: Extracellular signal peptide that regulates cell
CC fate. {ECO:0000269|PubMed:16489133}.
CC -!- SUBCELLULAR LOCATION: [CLE5p]: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:O49519}.
CC -!- TISSUE SPECIFICITY: [CLE5p]: Mostly expressed in roots, and, to a lower
CC extent, in seedlings, stems, apex, flowers and siliques.
CC {ECO:0000269|PubMed:12602871}.
CC -!- PTM: [CLE5p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-76 enhances binding affinity of the CLE5p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM15027.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC005311; AAM15027.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002685; AEC08490.1; -; Genomic_DNA.
DR EMBL; AY464584; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001325401.1; NM_001336315.1.
DR RefSeq; NP_850159.2; NM_179828.3.
DR AlphaFoldDB; Q8S8N2; -.
DR STRING; 3702.AT2G31083.1; -.
DR PaxDb; Q8S8N2; -.
DR PRIDE; Q8S8N2; -.
DR EnsemblPlants; AT2G31083.1; AT2G31083.1; AT2G31083.
DR GeneID; 817663; -.
DR Gramene; AT2G31083.1; AT2G31083.1; AT2G31083.
DR KEGG; ath:AT2G31083; -.
DR Araport; AT2G31083; -.
DR TAIR; locus:504955982; AT2G31083.
DR eggNOG; ENOG502SZED; Eukaryota.
DR HOGENOM; CLU_154904_2_0_1; -.
DR OMA; FQARILH; -.
DR OrthoDB; 1642840at2759; -.
DR PhylomeDB; Q8S8N2; -.
DR PRO; PR:Q8S8N2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8S8N2; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISM:TAIR.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; IPI:UniProtKB.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
DR InterPro; IPR039617; CLAVATA3-CLE.
DR PANTHER; PTHR36016; PTHR36016; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..81
FT /note="CLAVATA3/ESR (CLE)-related protein 5"
FT /id="PRO_0000401241"
FT PEPTIDE 70..81
FT /note="CLE5p"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT /id="PRO_0000401242"
FT MOD_RES 73
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MOD_RES 76
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 76
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 81 AA; 9132 MW; B49F081D003F0F35 CRC64;
MATLILKQTL IILLIIFSLQ TLSSQARILR SYRAVSMGNM DSQVLLHELG FDLSKFKGHN
ERRFLVSSDR VSPGGPDPQH H
