CLE6_ARATH
ID CLE6_ARATH Reviewed; 81 AA.
AC Q8S8N3;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 6 {ECO:0000303|PubMed:11457943, ECO:0000303|PubMed:16489133};
DE Contains:
DE RecName: Full=CLE6p {ECO:0000303|PubMed:11457943, ECO:0000303|PubMed:16489133};
DE Flags: Precursor;
GN Name=CLE6 {ECO:0000303|PubMed:11457943, ECO:0000303|PubMed:16489133,
GN ECO:0000303|PubMed:18034320}; Synonyms=CLE4;
GN OrderedLocusNames=At2g31085 {ECO:0000312|Araport:AT2G31085};
GN ORFNames=T16B12 {ECO:0000312|EMBL:AAM15025.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11457943; DOI=10.1104/pp.126.3.939;
RA Cock J.M., McCormick S.;
RT "A large family of genes that share homology with CLAVATA3.";
RL Plant Physiol. 126:939-942(2001).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=12602871; DOI=10.1023/a:1022038932376;
RA Sharma V.K., Ramirez J., Fletcher J.C.;
RT "The Arabidopsis CLV3-like (CLE) genes are expressed in diverse tissues and
RT encode secreted proteins.";
RL Plant Mol. Biol. 51:415-425(2003).
RN [6]
RP FUNCTION.
RX PubMed=16407446; DOI=10.1104/pp.105.072678;
RA Ni J., Clark S.E.;
RT "Evidence for functional conservation, sufficiency, and proteolytic
RT processing of the CLAVATA3 CLE domain.";
RL Plant Physiol. 140:726-733(2006).
RN [7]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=16489133; DOI=10.1104/pp.105.075515;
RA Strabala T.J., O'donnell P.J., Smit A.-M., Ampomah-Dwamena C., Martin E.J.,
RA Netzler N., Nieuwenhuizen N.J., Quinn B.D., Foote H.C.C., Hudson K.R.;
RT "Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new
RT family members, correlate with tandem variations in the conserved
RT CLAVATA3/ESR domain.";
RL Plant Physiol. 140:1331-1344(2006).
RN [8]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [9]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [10]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
CC -!- FUNCTION: [CLE6p]: Extracellular signal peptide that regulates cell
CC fate. {ECO:0000269|PubMed:16407446, ECO:0000269|PubMed:16489133}.
CC -!- SUBCELLULAR LOCATION: [CLE6p]: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:O49519}.
CC -!- TISSUE SPECIFICITY: [CLE6p]: Mostly expressed in roots, seedlings,
CC stems and flowers, and, to a lower extent, in apex and siliques.
CC {ECO:0000269|PubMed:12602871}.
CC -!- PTM: [CLE6p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-76 enhances binding affinity of the CLE6p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC005311; AAM15025.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08491.1; -; Genomic_DNA.
DR EMBL; AY086725; AAM67246.1; -; mRNA.
DR RefSeq; NP_565713.1; NM_128664.2.
DR AlphaFoldDB; Q8S8N3; -.
DR STRING; 3702.AT2G31085.1; -.
DR PaxDb; Q8S8N3; -.
DR PRIDE; Q8S8N3; -.
DR EnsemblPlants; AT2G31085.1; AT2G31085.1; AT2G31085.
DR GeneID; 817664; -.
DR Gramene; AT2G31085.1; AT2G31085.1; AT2G31085.
DR KEGG; ath:AT2G31085; -.
DR Araport; AT2G31085; -.
DR TAIR; locus:505006281; AT2G31085.
DR HOGENOM; CLU_154904_2_0_1; -.
DR OMA; ILRTYHP; -.
DR OrthoDB; 1642840at2759; -.
DR PhylomeDB; Q8S8N3; -.
DR PRO; PR:Q8S8N3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8S8N3; baseline and differential.
DR Genevisible; Q8S8N3; AT.
DR GO; GO:0048046; C:apoplast; ISM:TAIR.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
DR GO; GO:2000023; P:regulation of lateral root development; IDA:UniProtKB.
DR GO; GO:2000067; P:regulation of root morphogenesis; IDA:UniProtKB.
DR InterPro; IPR039617; CLAVATA3-CLE.
DR PANTHER; PTHR36016; PTHR36016; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..81
FT /note="CLAVATA3/ESR (CLE)-related protein 6"
FT /id="PRO_0000401243"
FT PEPTIDE 70..81
FT /note="CLE6p"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT /id="PRO_0000401244"
FT MOD_RES 73
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MOD_RES 76
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 76
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 81 AA; 9192 MW; CB92FD84CA418C1F CRC64;
MANLILKQSL IILLIIYSTP ILSSQARILR TYRPTTMGDM DSQVLLRELG IDLSKFKGQD
ERRFLVDSER VSPGGPDPQH H
