CLE7_ARATH
ID CLE7_ARATH Reviewed; 86 AA.
AC Q8S8N1;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=CLAVATA3/ESR (CLE)-related protein 7 {ECO:0000303|PubMed:11457943};
DE Contains:
DE RecName: Full=CLE7p {ECO:0000303|PubMed:11457943};
DE Flags: Precursor;
GN Name=CLE7 {ECO:0000303|PubMed:11457943, ECO:0000303|PubMed:16489133,
GN ECO:0000303|PubMed:18034320}; Synonyms=CLE5;
GN OrderedLocusNames=At2g31082 {ECO:0000312|Araport:AT2G31082};
GN ORFNames=T16B12 {ECO:0000312|EMBL:AAM15028.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11457943; DOI=10.1104/pp.126.3.939;
RA Cock J.M., McCormick S.;
RT "A large family of genes that share homology with CLAVATA3.";
RL Plant Physiol. 126:939-942(2001).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12602871; DOI=10.1023/a:1022038932376;
RA Sharma V.K., Ramirez J., Fletcher J.C.;
RT "The Arabidopsis CLV3-like (CLE) genes are expressed in diverse tissues and
RT encode secreted proteins.";
RL Plant Mol. Biol. 51:415-425(2003).
RN [5]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=16489133; DOI=10.1104/pp.105.075515;
RA Strabala T.J., O'donnell P.J., Smit A.-M., Ampomah-Dwamena C., Martin E.J.,
RA Netzler N., Nieuwenhuizen N.J., Quinn B.D., Foote H.C.C., Hudson K.R.;
RT "Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new
RT family members, correlate with tandem variations in the conserved
RT CLAVATA3/ESR domain.";
RL Plant Physiol. 140:1331-1344(2006).
RN [6]
RP REVIEW.
RX PubMed=18034320; DOI=10.1007/s00018-007-7411-5;
RA Jun J.H., Fiume E., Fletcher J.C.;
RT "The CLE family of plant polypeptide signaling molecules.";
RL Cell. Mol. Life Sci. 65:743-755(2008).
RN [7]
RP REVIEW.
RX PubMed=18078779; DOI=10.1016/j.pbi.2007.10.010;
RA Mitchum M.G., Wang X., Davis E.L.;
RT "Diverse and conserved roles of CLE peptides.";
RL Curr. Opin. Plant Biol. 11:75-81(2008).
RN [8]
RP REVIEW.
RX PubMed=20016993; DOI=10.1007/s00709-009-0095-y;
RA Wang G., Fiers M.;
RT "CLE peptide signaling during plant development.";
RL Protoplasma 240:33-43(2010).
CC -!- FUNCTION: [CLE7p]: Extracellular signal peptide that regulates cell
CC fate. {ECO:0000269|PubMed:16489133}.
CC -!- SUBCELLULAR LOCATION: [CLE7p]: Secreted, extracellular space
CC {ECO:0000250|UniProtKB:O49519}.
CC -!- TISSUE SPECIFICITY: [CLE7p]: Expressed in roots and seedlings.
CC {ECO:0000269|PubMed:12602871}.
CC -!- PTM: [CLE7p]: The O-glycosylation (arabinosylation) of the
CC hydroxyproline Pro-71 enhances binding affinity of the CLE7p peptide
CC for its receptor. {ECO:0000250|UniProtKB:O49519}.
CC -!- SIMILARITY: Belongs to the CLV3/ESR signal peptide family.
CC {ECO:0000305}.
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DR EMBL; AC005311; AAM15028.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08489.1; -; Genomic_DNA.
DR RefSeq; NP_850158.1; NM_179827.2.
DR AlphaFoldDB; Q8S8N1; -.
DR BioGRID; 3010; 1.
DR STRING; 3702.AT2G31082.1; -.
DR PaxDb; Q8S8N1; -.
DR EnsemblPlants; AT2G31082.1; AT2G31082.1; AT2G31082.
DR GeneID; 817662; -.
DR Gramene; AT2G31082.1; AT2G31082.1; AT2G31082.
DR KEGG; ath:AT2G31082; -.
DR Araport; AT2G31082; -.
DR TAIR; locus:504955981; AT2G31082.
DR HOGENOM; CLU_154904_1_0_1; -.
DR InParanoid; Q8S8N1; -.
DR OrthoDB; 1642840at2759; -.
DR PhylomeDB; Q8S8N1; -.
DR PRO; PR:Q8S8N1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8S8N1; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISM:TAIR.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0045168; P:cell-cell signaling involved in cell fate commitment; ISS:UniProtKB.
DR InterPro; IPR039617; CLAVATA3-CLE.
DR PANTHER; PTHR36016; PTHR36016; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Hydroxylation;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..86
FT /note="CLAVATA3/ESR (CLE)-related protein 7"
FT /id="PRO_0000401245"
FT PEPTIDE 65..76
FT /note="CLE7p"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT /id="PRO_0000401246"
FT REGION 63..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 68
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT MOD_RES 71
FT /note="Hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 71
FT /note="O-linked (Ara...) hydroxyproline"
FT /evidence="ECO:0000250|UniProtKB:O49519"
SQ SEQUENCE 86 AA; 9738 MW; F4AC265B3A01307A CRC64;
MASKALLLFV MLTFLLVIEM EGRILRVNSK TKDGESNDLL KRLGYNVSEL KRIGRELSVQ
NEVDRFSPGG PDPQHHSYPL SSKPRI
