ID   CLEA_CONCF              Reviewed;          27 AA.
AC   P0C6S2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Kappa-conotoxin-like as14a;
OS   Conus cancellatus (Cancellate cone) (Conus austini).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dauciconus.
OX   NCBI_TaxID=289020;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=18206266; DOI=10.1016/j.peptides.2007.09.021;
RA   Zugasti-Cruz A., Aguilar M.B., Falcon A., Olivera B.M.,
RA   Heimer de la Cotera E.P.;
RT   "Two new 4-Cys conotoxins (framework 14) of the vermivorous snail Conus
RT   austini from the Gulf of Mexico with activity in the central nervous system
RT   of mice.";
RL   Peptides 29:179-185(2008).
CC   -!- FUNCTION: Blocks potassium channels (By similarity). When
CC       intracranially injected, elicits scratching and grooming activity in
CC       mice. {ECO:0000250, ECO:0000269|PubMed:18206266}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18206266}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:18206266}.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C).
CC   -!- MASS SPECTROMETRY: Mass=2883.92; Method=MALDI; Note=Monoisotopic mass.;
CC       Evidence={ECO:0000269|PubMed:18206266};
CC   -!- SIMILARITY: Belongs to the conotoxin L superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C6S2; -.
DR   SMR; P0C6S2; -.
DR   ConoServer; 2828; AsXIVA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Toxin.
FT   PEPTIDE         1..27
FT                   /note="Kappa-conotoxin-like as14a"
FT                   /id="PRO_0000326393"
FT   DISULFID        6..26
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..22
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   27 AA;  2890 MW;  97A8E2C1EAAA526D CRC64;
     GGVGRCIYNC MNSGGGLNFI QCKTMCY