ID   CLEB_CONCF              Reviewed;          28 AA.
AC   P0C6S3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Kappa-conotoxin-like as14b;
DE   Flags: Precursor;
OS   Conus cancellatus (Cancellate cone) (Conus austini).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dauciconus.
OX   NCBI_TaxID=289020;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=18206266; DOI=10.1016/j.peptides.2007.09.021;
RA   Zugasti-Cruz A., Aguilar M.B., Falcon A., Olivera B.M.,
RA   Heimer de la Cotera E.P.;
RT   "Two new 4-Cys conotoxins (framework 14) of the vermivorous snail Conus
RT   austini from the Gulf of Mexico with activity in the central nervous system
RT   of mice.";
RL   Peptides 29:179-185(2008).
CC   -!- FUNCTION: Blocks potassium channels (By similarity). When
CC       intracranially injected, elicits scratching and grooming activity in
CC       mice, and causes body and rear limb extension and tail curling
CC       immediately upon injection. {ECO:0000250, ECO:0000269|PubMed:18206266}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18206266}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:18206266}.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C).
CC   -!- MASS SPECTROMETRY: Mass=3308.63; Method=MALDI; Note=Monoisotopic mass.;
CC       Evidence={ECO:0000269|PubMed:18206266};
CC   -!- SIMILARITY: Belongs to the conotoxin L superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C6S3; -.
DR   SMR; P0C6S3; -.
DR   ConoServer; 2829; AsXIVB precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Toxin.
FT   PEPTIDE         1..28
FT                   /note="Kappa-conotoxin-like as14b"
FT                   /id="PRO_0000326394"
FT   DISULFID        7..27
FT                   /evidence="ECO:0000250"
FT   DISULFID        11..23
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   28 AA;  3315 MW;  8E0A92128F384997 CRC64;
     RWDVDQCIYY CLNGVVGYSY TECQTMCT