ID   CLEC_CONAW              Reviewed;         122 AA.
AC   P84707; A0A3G1VU88;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 2.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Conotoxin flf14c {ECO:0000303|PubMed:16331958, ECO:0000303|PubMed:30040981};
DE   AltName: Full=Conotoxin flf14.1 {ECO:0000303|PubMed:30040981};
DE   Flags: Precursor;
OS   Conus anabathrum floridanus (Florida cone) (Conus floridanus floridensis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dauciconus.
OX   NCBI_TaxID=1520082;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=30040981; DOI=10.1016/j.peptides.2018.06.002;
RA   Moeller C., Dovell S., Melaun C., Mari F.;
RT   "Definition of the R-superfamily of conotoxins: structural convergence of
RT   helix-loop-helix peptidic scaffolds.";
RL   Peptides 107:75-82(2018).
RN   [2]
RP   PROTEIN SEQUENCE OF 96-122, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP   DISULFIDE BONDS.
RC   TISSUE=Venom;
RX   PubMed=16331958; DOI=10.1021/bi0511181;
RA   Moller C., Rahmankhah S., Lauer-Fields J., Bubis J., Fields G.B., Mari F.;
RT   "A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha)
RT   fold.";
RL   Biochemistry 44:15986-15996(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16331958}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:16331958}.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=3280.4; Mass_error=0.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16331958};
CC   -!- SIMILARITY: Belongs to the conotoxin R superfamily. {ECO:0000305}.
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DR   EMBL; MH750030; AYK27403.1; -; mRNA.
DR   AlphaFoldDB; P84707; -.
DR   SMR; P84707; -.
DR   ConoServer; 1497; FlfXIVC.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..96
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000446989"
FT   PEPTIDE         96..122
FT                   /note="Conotoxin flf14c"
FT                   /evidence="ECO:0000269|PubMed:16331958"
FT                   /id="PRO_0000044517"
FT   REGION          53..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        101..121
FT                   /evidence="ECO:0000269|PubMed:16331958"
FT   DISULFID        105..117
FT                   /evidence="ECO:0000269|PubMed:16331958"
SQ   SEQUENCE   122 AA;  14192 MW;  739EAEB0896BA6D7 CRC64;
     MGFRVLVLIV MVTTSALPFT FSEESGRSPF RPALRSEEAQ ALRHGLTLLL ARRADGQTPD
     MHQPEMRRPE MRRPEVRRPE VRQPEFAESP VGQKRWDAYD CIQFCMRPEM RHTYAQCLSI
     CT