ID   CLF1_ASHGO              Reviewed;         683 AA.
AC   Q750X3;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Pre-mRNA-splicing factor CLF1;
GN   Name=CLF1; OrderedLocusNames=AGL184W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       Required for the spliceosome assembly and initiation of the DNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54307.1; -; Genomic_DNA.
DR   RefSeq; NP_986483.1; NM_211545.1.
DR   AlphaFoldDB; Q750X3; -.
DR   SMR; Q750X3; -.
DR   STRING; 33169.AAS54307; -.
DR   EnsemblFungi; AAS54307; AAS54307; AGOS_AGL184W.
DR   GeneID; 4622776; -.
DR   KEGG; ago:AGOS_AGL184W; -.
DR   eggNOG; KOG1915; Eukaryota.
DR   HOGENOM; CLU_011554_1_0_1; -.
DR   InParanoid; Q750X3; -.
DR   OMA; HIKVWIS; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR   GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR008847; Suf.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF05843; Suf; 1.
DR   SMART; SM00386; HAT; 12.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..683
FT                   /note="Pre-mRNA-splicing factor CLF1"
FT                   /id="PRO_0000205738"
FT   REPEAT          40..72
FT                   /note="HAT 1"
FT   REPEAT          74..106
FT                   /note="HAT 2"
FT   REPEAT          108..140
FT                   /note="HAT 3"
FT   REPEAT          142..173
FT                   /note="HAT 4"
FT   REPEAT          175..206
FT                   /note="HAT 5"
FT   REPEAT          291..323
FT                   /note="HAT 6"
FT   REPEAT          336..367
FT                   /note="HAT 7"
FT   REPEAT          374..407
FT                   /note="HAT 8"
FT   REPEAT          409..440
FT                   /note="HAT 9"
FT   REPEAT          442..474
FT                   /note="HAT 10"
FT   REPEAT          476..513
FT                   /note="HAT 11"
FT   REPEAT          515..547
FT                   /note="HAT 12"
FT   REPEAT          582..620
FT                   /note="HAT 13"
SQ   SEQUENCE   683 AA;  79431 MW;  9B4D75BEB0CC29B8 CRC64;
     MTEATKEDVT AAQLLTAPVG HDGARKGMDV DILDVEELRD WQRRKRSEFE EALKRNRLDV
     RQWLRYAAFE YEQRDMRRAR SVFERALAVA PGDVVVWLRY VDCELRARDV NHARNLLVRA
     TALLPRVDKL WYKYVLMEES LGQVELVRGV YTKWCTLEPA AAAWDAFVDF ETRQGQVEHV
     REVYSRYVMV HPVAATWLKW VAFERKHGDA GTVRRVYSLA CDTLTAFAGA DVHEVEQLVV
     SFAEWEATQQ ELERSRAVLS VAVSRWPESS TLKDATAQLE KKFGGARAGE SILFKRKREY
     EEQLLAHPLD YDAWWLYLDL LEESFPAELR AALAEATVKA VPRSQEKDMQ WRKYVNLWLR
     YLLFLETVLV DSDLTRSMYQ KLVREVIPNT KFTFAKAWIM YAEFEIRQEK LDKARKILGM
     SLGMCPKPKL FQYYIDLEIK LKEFDRVRRL HEKLLEFQPD VLSNWIEYAE LEENLGDEDR
     ARGIYEIGLT ADGGLSQARQ LQLMQRYIQF ETDASEFERA RALYSRYVAL SGYDPNVWIS
     CALYESSVPT AAQVASYAHD QPNSDGDDSD DAYEQEFELT EENKEQTRAI FEKALRHYTS
     EKDDEGRILV LQAYKDYESI HGSAEARQKI ASRQPRKVTR KRTVDGIEKE YVAYEFPDDT
     VSTSSVASKF VSLAQRWKQQ QAP