CLF1_ASPFU
ID CLF1_ASPFU Reviewed; 676 AA.
AC Q4WT84;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Pre-mRNA-splicing factor clf1;
GN Name=clf1; ORFNames=AFUA_1G10200;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC Required for the spliceosome assembly and initiation of the DNA
CC replication (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR EMBL; AAHF01000004; EAL90348.1; -; Genomic_DNA.
DR RefSeq; XP_752386.1; XM_747293.1.
DR AlphaFoldDB; Q4WT84; -.
DR SMR; Q4WT84; -.
DR STRING; 746128.CADAFUBP00000943; -.
DR PRIDE; Q4WT84; -.
DR EnsemblFungi; EAL90348; EAL90348; AFUA_1G10200.
DR GeneID; 3510367; -.
DR KEGG; afm:AFUA_1G10200; -.
DR VEuPathDB; FungiDB:Afu1g10200; -.
DR eggNOG; KOG1915; Eukaryota.
DR HOGENOM; CLU_011554_1_0_1; -.
DR InParanoid; Q4WT84; -.
DR OMA; HIKVWIS; -.
DR OrthoDB; 355408at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246; PTHR11246; 1.
DR Pfam; PF02184; HAT; 2.
DR SMART; SM00386; HAT; 15.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome.
FT CHAIN 1..676
FT /note="Pre-mRNA-splicing factor clf1"
FT /id="PRO_0000205739"
FT REPEAT 52..84
FT /note="HAT 1"
FT REPEAT 86..118
FT /note="HAT 2"
FT REPEAT 120..152
FT /note="HAT 3"
FT REPEAT 154..185
FT /note="HAT 4"
FT REPEAT 187..218
FT /note="HAT 5"
FT REPEAT 220..255
FT /note="HAT 6"
FT REPEAT 257..291
FT /note="HAT 7"
FT REPEAT 301..333
FT /note="HAT 8"
FT REPEAT 335..369
FT /note="HAT 9"
FT REPEAT 379..415
FT /note="HAT 10"
FT REPEAT 417..448
FT /note="HAT 11"
FT REPEAT 450..482
FT /note="HAT 12"
FT REPEAT 484..518
FT /note="HAT 13"
FT REPEAT 520..551
FT /note="HAT 14"
FT REPEAT 572..610
FT /note="HAT 15"
FT REGION 554..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 81970 MW; EB2698A514F86A59 CRC64;
MESSRGPPRV KNKAPAPIQI SAEQLLREAV DRQEPALQAP TQRFADLEEL HEYQGRKRKE
FEDYVRRNRL NMNNWMRYAS WELEQKEFRR ARSIFERALD VNPTSVVLWI RYIESEMRNR
NINHARNLLD RAVTILPRVD KFWYKYVYME ETLGNIQGTR QVFERWMSWE PDEGAWSAYI
KLEKRYNEFE RARAIFQRFT IVHPEPRNWI KWARFEEEYG TSDLVREVYG MAIETLGEDF
MDEKLFIAYA KFEAKLKEYE RARAIYKYAL DRLPRSKAMA LHKAYTTFEK QFGDREGVED
VILSKRRVQY EEQLKENPRN YDVWFDFARL EETSGDPDRV RDIYERAIAQ IPPSQEKRHW
RRYIYLWIFY AIWEEMEAKD VDRARQIYTE CLKLIPHKKF TFAKIWLLKA QFDIRQMDLQ
AARKTLGQAI GMCPKDKLFR GYIDLERQLF EFVRCRTLYE KQIEWNPANS QSWIKYAELE
RGLDDSERAR AIFELGIDQP MLDMPELVWK AYIDFEEYEG EYDRVRQLYE RLLQKTDHVK
VWINYARFEI NVPEEEEEEE EEEEEERPVS DEAKRRARAV FERAHKVFKE KEMKEERVEL
LNAWRAFEHT HGSPEDIKKI EEQMPRRVKK RRKLDDDRYE EYMDYVFPAD DQAAASLTKI
LQAAHRWKQT GGQVVP
