CLF1_CANAL
ID CLF1_CANAL Reviewed; 701 AA.
AC Q5AED6; A0A1D8PJN8; Q5AES1;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 3.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Pre-mRNA-splicing factor CLF1;
GN Name=CLF1; OrderedLocusNames=CAALFM_C303330CA;
GN ORFNames=CaO19.332, CaO19.7964;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC Required for the spliceosome assembly and initiation of the DNA
CC replication (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR EMBL; CP017625; AOW28362.1; -; Genomic_DNA.
DR RefSeq; XP_720027.2; XM_714934.2.
DR AlphaFoldDB; Q5AED6; -.
DR SMR; Q5AED6; -.
DR STRING; 237561.Q5AED6; -.
DR GeneID; 3638364; -.
DR KEGG; cal:CAALFM_C303330CA; -.
DR CGD; CAL0000187187; orf19.7964.
DR VEuPathDB; FungiDB:C3_03330C_A; -.
DR eggNOG; KOG1915; Eukaryota.
DR HOGENOM; CLU_011554_1_0_1; -.
DR InParanoid; Q5AED6; -.
DR OMA; HIKVWIS; -.
DR OrthoDB; 355408at2759; -.
DR PRO; PR:Q5AED6; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11246; PTHR11246; 1.
DR SMART; SM00386; HAT; 10.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome.
FT CHAIN 1..701
FT /note="Pre-mRNA-splicing factor CLF1"
FT /id="PRO_0000205740"
FT REPEAT 43..75
FT /note="HAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 78..110
FT /note="HAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 112..144
FT /note="HAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 146..177
FT /note="HAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 179..210
FT /note="HAT 5"
FT /evidence="ECO:0000255"
FT REPEAT 214..253
FT /note="HAT 6"
FT /evidence="ECO:0000255"
FT REPEAT 266..299
FT /note="HAT 7"
FT /evidence="ECO:0000255"
FT REPEAT 309..341
FT /note="HAT 8"
FT /evidence="ECO:0000255"
FT REPEAT 343..378
FT /note="HAT 9"
FT /evidence="ECO:0000255"
FT REPEAT 388..424
FT /note="HAT 10"
FT /evidence="ECO:0000255"
FT REPEAT 545..576
FT /note="HAT 11"
FT /evidence="ECO:0000255"
FT REPEAT 601..642
FT /note="HAT 12"
FT /evidence="ECO:0000255"
SQ SEQUENCE 701 AA; 83731 MW; FAFBE62F7AC2C549 CRC64;
MNETSNRDHQ VTSKEILDVA FEKSKSKFTT PRQTIQDTEE LQSYQQTKRK EFEQHINKNR
LNLGQWTRYA KWEIENNHDF PRARSILERA LDVNIQHVPF WIQYIQLELS HKNINHARNL
MERAINTLPR VNKLWFLYVQ TEEMLKNYPM VRAVFERWLD WHPDTSAWDA YINFEARYEE
KENVRTIFKK YVHEFPNAGT WYKWIKYEME NNRDDVNTVR AVFESAVDTL LSNKSEENDD
DEEFATIISS WTSWEVSCGE ASRANEIFKL LLDNKTNKLE ISDQTKSSIY TAFVEFEKNF
GNKDSIEQSV LIKRRIKYEQ EIQNDPYDYD SWWKYMTLLQ NSSNKSDLEN AFKKVTGNVV
HDKHKSIKWR RYIMFWIWYA FWEEMTNNNP VSAREIWNNC LKVIPHKSFT FAKVWIGYSE
FELRNSEDGL AKARKILGRA IGQTSINKPK IKIFKYYIDL EKKLGDWNRV RLLFQKWLEV
SLLTTSSSEL VIEKYVEFES SIEEYDRCDS ILSSARQLSE NPEYSSSFNL QRLLEITVEF
YKEEMQYDKI REIYRALLDK DPNAHNWISF ALFESSIPSA EQLEEYLQGD NEEFEATVDE
SQIESTRNIF EEAMTYFKDK DDKESRLVII EAWRDFEEVN GSDESLSKVT KRLPVIVRKR
RTVGSIEEEY IDYIFPDDES KKLPGKMSKF LANAKKWAQQ N
