ID   CLF1_CANGA              Reviewed;         695 AA.
AC   Q6FW76;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Pre-mRNA-splicing factor CLF1;
GN   Name=CLF1; OrderedLocusNames=CAGL0D02376g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       Required for the spliceosome assembly and initiation of the DNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; CR380950; CAG58429.1; -; Genomic_DNA.
DR   RefSeq; XP_445518.1; XM_445518.1.
DR   AlphaFoldDB; Q6FW76; -.
DR   SMR; Q6FW76; -.
DR   STRING; 5478.XP_445518.1; -.
DR   EnsemblFungi; CAG58429; CAG58429; CAGL0D02376g.
DR   GeneID; 2887048; -.
DR   KEGG; cgr:CAGL0D02376g; -.
DR   CGD; CAL0128287; CAGL0D02376g.
DR   VEuPathDB; FungiDB:CAGL0D02376g; -.
DR   eggNOG; KOG1915; Eukaryota.
DR   HOGENOM; CLU_011554_1_0_1; -.
DR   InParanoid; Q6FW76; -.
DR   OMA; HIKVWIS; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR   GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   SMART; SM00386; HAT; 11.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..695
FT                   /note="Pre-mRNA-splicing factor CLF1"
FT                   /id="PRO_0000205741"
FT   REPEAT          41..73
FT                   /note="HAT 1"
FT   REPEAT          75..107
FT                   /note="HAT 2"
FT   REPEAT          109..141
FT                   /note="HAT 3"
FT   REPEAT          143..174
FT                   /note="HAT 4"
FT   REPEAT          176..207
FT                   /note="HAT 5"
FT   REPEAT          296..328
FT                   /note="HAT 6"
FT   REPEAT          333..365
FT                   /note="HAT 7"
FT   REPEAT          375..412
FT                   /note="HAT 8"
FT   REPEAT          414..445
FT                   /note="HAT 9"
FT   REPEAT          447..479
FT                   /note="HAT 10"
FT   REPEAT          521..553
FT                   /note="HAT 11"
FT   REPEAT          591..629
FT                   /note="HAT 12"
SQ   SEQUENCE   695 AA;  83375 MW;  923FA9118D2F2599 CRC64;
     MTEIPAKQIT DNDILKDVYK SQNKQFSIDA IDILDLEELK DVQRRKRTEF EGYLKRNRLD
     VKQWMRYAVF EIEQHDMRRA RSIFERALRV HISYVPLWIR YIESELKLGY INHARNILER
     AITKLPRVDK LWYKYLIVEE SLAHFDIVRN LFQKWCSLEP AAHVWDSFTD FEVRQERYED
     VRNIYSKYVL IHPQFSTWRK WINFEVRYGS TKTVRSVYSL ALDALIAYSE SRNELVDDCI
     NLIVEFSKWE ALQKEYIRSK SLLEIAIQKW PKSNTLNNAL LQFEREHGTA ETLENTIILN
     RKKHYEDILN EKVYDYDTWL LYLQLLENNY PKLVMEAFSN VLNAAIPTSR TKDKYWKQYI
     LIWIKYLTFL ELTINDIPLC GQKFEELIHN IIPNDDFTFS KIWILYAEFE IRQDNLEKAR
     SILGRSLGLC PKRKTFKYYI DLETKLREFD RVRILYENFL KFDPLNLDTW RAYVEFEDSL
     GDEVRVRSVC MIPIQNNIGL FSKSFQLHLL EILIDYEMEY QNFDNIEPLL KKQVELSNFT
     VEAWTDYAMK KLTVPTEEQV QNFQIMKEER LKDSSALDEQ EIEFEFEITD NNKDNARDVF
     ERALNYFKEI KRDEDRARIL QSYVDFEGQY GDISSRQRIE KRLPSIVNGI KDIDGLKTQN
     ITYTFPDDEN KSNIDTSNIL ALAHKWKESQ EAKSR