位置:首页 > 蛋白库 > CLF1_CRYNB
CLF1_CRYNB
ID   CLF1_CRYNB              Reviewed;         726 AA.
AC   P0CO11; Q55Z33; Q5KNE9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Pre-mRNA-splicing factor CLF1;
GN   Name=CLF1; OrderedLocusNames=CNBA6540;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       Required for the spliceosome assembly and initiation of the DNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAEY01000005; EAL22885.1; -; Genomic_DNA.
DR   RefSeq; XP_777532.1; XM_772439.1.
DR   AlphaFoldDB; P0CO11; -.
DR   SMR; P0CO11; -.
DR   EnsemblFungi; AAW41086; AAW41086; CNA06730.
DR   EnsemblFungi; EAL22885; EAL22885; CNBA6540.
DR   GeneID; 4933919; -.
DR   KEGG; cnb:CNBA6540; -.
DR   VEuPathDB; FungiDB:CNBA6540; -.
DR   HOGENOM; CLU_011554_1_0_1; -.
DR   Proteomes; UP000001435; Chromosome 1.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR   GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF02184; HAT; 1.
DR   SMART; SM00386; HAT; 14.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Repeat; Spliceosome.
FT   CHAIN           1..726
FT                   /note="Pre-mRNA-splicing factor CLF1"
FT                   /id="PRO_0000410110"
FT   REPEAT          55..87
FT                   /note="HAT 1"
FT   REPEAT          89..121
FT                   /note="HAT 2"
FT   REPEAT          123..155
FT                   /note="HAT 3"
FT   REPEAT          157..188
FT                   /note="HAT 4"
FT   REPEAT          190..221
FT                   /note="HAT 5"
FT   REPEAT          223..262
FT                   /note="HAT 6"
FT   REPEAT          264..298
FT                   /note="HAT 7"
FT   REPEAT          308..340
FT                   /note="HAT 8"
FT   REPEAT          352..386
FT                   /note="HAT 9"
FT   REPEAT          396..432
FT                   /note="HAT 10"
FT   REPEAT          434..465
FT                   /note="HAT 11"
FT   REPEAT          467..499
FT                   /note="HAT 12"
FT   REPEAT          501..534
FT                   /note="HAT 13"
FT   REPEAT          536..567
FT                   /note="HAT 14"
FT   REPEAT          585..626
FT                   /note="HAT 15"
FT   REPEAT          635..667
FT                   /note="HAT 16"
FT   REGION          682..726
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        699..726
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   726 AA;  85624 MW;  1971DA6B52A49409 CRC64;
     MAGRDPRDRA PRVRNRAPAA VQITAEQLLR EAQERQEPAI QAPKQRVQDL EELSEFQARK
     RTEFESRIRY SRDSILAWTK YAQWEASQNE YERSRSVFER ALDVDPRSVD LWIKYTDMEL
     KARNINHARN LFDRAITLLP RVDALWYKYV YLEELLLNVS GARQIFERWM QWEPNDKAWQ
     SYIKLEERYN ELDRASAIYE RWIACRPIPK NWVTWAKFEE DRGQPDKARE VFQTALEFFG
     DEEEQVEKAQ SVFAAFARME TRLKEFERAR VIYKFALARL PRSKSASLYA QYTKFEKQHG
     DRAGVELTVL GKRRIQYEEE LAYDPTNYDA WFSLARLEED AYRADREDGE DVEPMRVREV
     YERAVANVPP ALEKRYWRRY IYLWLQYAAF EEIDTKDYDR ARDVYKAAVK LVPHKTFTFA
     KLWLAYAYFE IRRLDVSAAR KVLGAGIGMC PKPKLFTGYI ELEMRLREFD RVRTLYEKFL
     TYDPSLSSAW IQWTQVESAV EDFERVRAIF ELAVQQSLDM PEIVWKAYID FEAGEGERER
     ARNLYERLLE RTSHVKVWIS YALMEIATLG GGEDEDGNEI EGEAGDADLA RQVFERGYKD
     LRAKGEKEDR AVLLESWKSF EQEHGDEETL AKVEDMLPTT RKRWRKAEDG SGELEEYWDL
     VFPDDEREAN PTSFKFFQAA QAWAQQRAGQ GEEGGLSYDL PSDSEDENED GDEDGDGREE
     EGMDQD
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024