CLF1_CRYNJ
ID CLF1_CRYNJ Reviewed; 726 AA.
AC P0CO10; Q55Z33; Q5KNE9;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Pre-mRNA-splicing factor CLF1;
GN Name=CLF1; OrderedLocusNames=CNA06730;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC Required for the spliceosome assembly and initiation of the DNA
CC replication (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR EMBL; AE017341; AAW41086.1; -; Genomic_DNA.
DR RefSeq; XP_566905.1; XM_566905.1.
DR AlphaFoldDB; P0CO10; -.
DR SMR; P0CO10; -.
DR STRING; 5207.AAW41086; -.
DR PaxDb; P0CO10; -.
DR EnsemblFungi; AAW41086; AAW41086; CNA06730.
DR GeneID; 3253209; -.
DR KEGG; cne:CNA06730; -.
DR VEuPathDB; FungiDB:CNA06730; -.
DR eggNOG; KOG1915; Eukaryota.
DR HOGENOM; CLU_011554_1_0_1; -.
DR InParanoid; P0CO10; -.
DR OMA; HIKVWIS; -.
DR OrthoDB; 355408at2759; -.
DR Proteomes; UP000002149; Chromosome 1.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246; PTHR11246; 1.
DR Pfam; PF02184; HAT; 1.
DR SMART; SM00386; HAT; 14.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome.
FT CHAIN 1..726
FT /note="Pre-mRNA-splicing factor CLF1"
FT /id="PRO_0000205742"
FT REPEAT 55..87
FT /note="HAT 1"
FT REPEAT 89..121
FT /note="HAT 2"
FT REPEAT 123..155
FT /note="HAT 3"
FT REPEAT 157..188
FT /note="HAT 4"
FT REPEAT 190..221
FT /note="HAT 5"
FT REPEAT 223..262
FT /note="HAT 6"
FT REPEAT 264..298
FT /note="HAT 7"
FT REPEAT 308..340
FT /note="HAT 8"
FT REPEAT 352..386
FT /note="HAT 9"
FT REPEAT 396..432
FT /note="HAT 10"
FT REPEAT 434..465
FT /note="HAT 11"
FT REPEAT 467..499
FT /note="HAT 12"
FT REPEAT 501..534
FT /note="HAT 13"
FT REPEAT 536..567
FT /note="HAT 14"
FT REPEAT 585..626
FT /note="HAT 15"
FT REPEAT 635..667
FT /note="HAT 16"
FT REGION 682..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..726
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 726 AA; 85624 MW; 1971DA6B52A49409 CRC64;
MAGRDPRDRA PRVRNRAPAA VQITAEQLLR EAQERQEPAI QAPKQRVQDL EELSEFQARK
RTEFESRIRY SRDSILAWTK YAQWEASQNE YERSRSVFER ALDVDPRSVD LWIKYTDMEL
KARNINHARN LFDRAITLLP RVDALWYKYV YLEELLLNVS GARQIFERWM QWEPNDKAWQ
SYIKLEERYN ELDRASAIYE RWIACRPIPK NWVTWAKFEE DRGQPDKARE VFQTALEFFG
DEEEQVEKAQ SVFAAFARME TRLKEFERAR VIYKFALARL PRSKSASLYA QYTKFEKQHG
DRAGVELTVL GKRRIQYEEE LAYDPTNYDA WFSLARLEED AYRADREDGE DVEPMRVREV
YERAVANVPP ALEKRYWRRY IYLWLQYAAF EEIDTKDYDR ARDVYKAAVK LVPHKTFTFA
KLWLAYAYFE IRRLDVSAAR KVLGAGIGMC PKPKLFTGYI ELEMRLREFD RVRTLYEKFL
TYDPSLSSAW IQWTQVESAV EDFERVRAIF ELAVQQSLDM PEIVWKAYID FEAGEGERER
ARNLYERLLE RTSHVKVWIS YALMEIATLG GGEDEDGNEI EGEAGDADLA RQVFERGYKD
LRAKGEKEDR AVLLESWKSF EQEHGDEETL AKVEDMLPTT RKRWRKAEDG SGELEEYWDL
VFPDDEREAN PTSFKFFQAA QAWAQQRAGQ GEEGGLSYDL PSDSEDENED GDEDGDGREE
EGMDQD
