ID   CLF1_DEBHA              Reviewed;         714 AA.
AC   Q6BSP7; B5RTE5;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Pre-mRNA-splicing factor CLF1;
GN   Name=CLF1; OrderedLocusNames=DEHA2D07172g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       Required for the spliceosome assembly and initiation of the DNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; CR382136; CAR65630.1; -; Genomic_DNA.
DR   RefSeq; XP_002770274.1; XM_002770228.1.
DR   AlphaFoldDB; Q6BSP7; -.
DR   SMR; Q6BSP7; -.
DR   STRING; 4959.XP_002770274.1; -.
DR   EnsemblFungi; CAR65630; CAR65630; DEHA2D07172g.
DR   GeneID; 8998482; -.
DR   KEGG; dha:DEHA2D07172g; -.
DR   VEuPathDB; FungiDB:DEHA2D07172g; -.
DR   eggNOG; KOG1915; Eukaryota.
DR   HOGENOM; CLU_011554_1_0_1; -.
DR   InParanoid; Q6BSP7; -.
DR   OMA; HIKVWIS; -.
DR   OrthoDB; 355408at2759; -.
DR   Proteomes; UP000000599; Chromosome D.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF02184; HAT; 1.
DR   SMART; SM00386; HAT; 11.
DR   SUPFAM; SSF48452; SSF48452; 3.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..714
FT                   /note="Pre-mRNA-splicing factor CLF1"
FT                   /id="PRO_0000205744"
FT   REPEAT          48..80
FT                   /note="HAT 1"
FT   REPEAT          83..115
FT                   /note="HAT 2"
FT   REPEAT          117..149
FT                   /note="HAT 3"
FT   REPEAT          151..182
FT                   /note="HAT 4"
FT   REPEAT          184..215
FT                   /note="HAT 5"
FT   REPEAT          265..305
FT                   /note="HAT 6"
FT   REPEAT          315..347
FT                   /note="HAT 7"
FT   REPEAT          349..384
FT                   /note="HAT 8"
FT   REPEAT          394..430
FT                   /note="HAT 9"
FT   REPEAT          435..470
FT                   /note="HAT 10"
FT   REPEAT          472..510
FT                   /note="HAT 11"
FT   REPEAT          555..586
FT                   /note="HAT 12"
SQ   SEQUENCE   714 AA;  85690 MW;  28AB41B8941ACA00 CRC64;
     MNTDGLSREK VSDSQITSEQ ILQDAFQLKD EPLNRPKQSI QDLDELRSFQ LTKRKEYEQQ
     LNKNRLNFGQ WLRYAKWEVK HNHDFPRARS IFERALEVNV QHIPFWTHYI QFELSHKNIT
     HARNLLDRAV TTLPRVDKLW FLYVQTEETL KNYQMVRIIF ERWLSWNPNP SAWDAYINYE
     KRYDEYDNAR EIYIRYVQIH SSGEIWLKWI DFEMNDVPID PEQVKRIRNV FELSVDSMLA
     SEALRGDISL AEIINKWSLW EISVKEYERA RAIFQLMLKS DTIQEIITPE QRNQIYSSYT
     EFEKSYGDKD TIESSIMIKR KLKYEEEVNK SPSDYDSWWS YISILQQEDN NEVTRETFER
     AIKVIPTDAF KSTVWRRYIY IWVKYAFWEE FTMGSIENGR NIWNKALKVI PHKRFTFAKI
     WISFAQFEIR NDPENGLASA RKILGRSIGQ SSTVKPKRKL FKFYIELEQK LGEWDRVRKL
     YEKWLELSLV GENNLSTINS LLTYIDFEKN IQEHQRCISL FELGVRLAED DKIFTKVNPL
     EYMLMQFINY YKEEMRYAEA RSLYRKLVER VSTPKVWISF ALFESSIPTD SQLKAFEEST
     EEEFEFSIDE THRETTRSVF REANDFFKHN NLKEDRAVVI EAWKQYEEAN GSEESLRDIT
     KKLPVIVKRR RLIEGEEEEY LDYIFPEDEE AKPSKISGLN AFLANAQKWM ANQN