ID   CLF1_EMENI              Reviewed;         673 AA.
AC   Q5BDX1; C8VSI2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Pre-mRNA-splicing factor clf1;
GN   Name=clf1; ORFNames=AN1259;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       Required for the spliceosome assembly and initiation of the DNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA65852.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AACD01000017; EAA65852.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BN001308; CBF87839.1; -; Genomic_DNA.
DR   RefSeq; XP_658863.1; XM_653771.1.
DR   AlphaFoldDB; Q5BDX1; -.
DR   SMR; Q5BDX1; -.
DR   STRING; 162425.CADANIAP00001364; -.
DR   PRIDE; Q5BDX1; -.
DR   EnsemblFungi; CBF87839; CBF87839; ANIA_01259.
DR   EnsemblFungi; EAA65852; EAA65852; AN1259.2.
DR   GeneID; 2877035; -.
DR   KEGG; ani:AN1259.2; -.
DR   VEuPathDB; FungiDB:AN1259; -.
DR   eggNOG; KOG1915; Eukaryota.
DR   HOGENOM; CLU_011554_1_0_1; -.
DR   InParanoid; Q5BDX1; -.
DR   OMA; HIKVWIS; -.
DR   OrthoDB; 355408at2759; -.
DR   Proteomes; UP000000560; Chromosome VIII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR   GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF02184; HAT; 2.
DR   SMART; SM00386; HAT; 14.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..673
FT                   /note="Pre-mRNA-splicing factor clf1"
FT                   /id="PRO_0000205745"
FT   REPEAT          52..84
FT                   /note="HAT 1"
FT   REPEAT          86..118
FT                   /note="HAT 2"
FT   REPEAT          120..152
FT                   /note="HAT 3"
FT   REPEAT          154..185
FT                   /note="HAT 4"
FT   REPEAT          187..218
FT                   /note="HAT 5"
FT   REPEAT          220..255
FT                   /note="HAT 6"
FT   REPEAT          257..291
FT                   /note="HAT 7"
FT   REPEAT          301..333
FT                   /note="HAT 8"
FT   REPEAT          335..369
FT                   /note="HAT 9"
FT   REPEAT          379..415
FT                   /note="HAT 10"
FT   REPEAT          417..448
FT                   /note="HAT 11"
FT   REPEAT          450..482
FT                   /note="HAT 12"
FT   REPEAT          484..518
FT                   /note="HAT 13"
FT   REPEAT          520..551
FT                   /note="HAT 14"
FT   REPEAT          569..607
FT                   /note="HAT 15"
SQ   SEQUENCE   673 AA;  81657 MW;  2572011001E8A6E3 CRC64;
     MEASRGPPRV KNKAPAPVQI SAEQLLREAV DRQEPSLQAP TQRFADLEEL HEYQGRKRKE
     FEDYVRRNRI NMNNWMRYAA WELEQKEFRR ARSIFERALD VDSTSVPLWI RYIESEMRNR
     NINHARNLLD RAVTILPRVD KLWYKYVYME ETLGNIPGTR QVFERWMSWE PDEGAWSAYI
     KLEKRYNEFE RARAIFQRFT IVHPEPRNWI KWARFEEEYG TSDLVREVYG LAVETLGEDF
     MDEKLFIAYA RFETKLKEYE RARAIYKYAL DRLPRSKSIT LHKAYTTFEK QFGDREGVEN
     VILAKRRVQY EEQLKENLRN YDVWFDFARL EEQSGDPERV RDVYERAIAQ IPPSQEKRHW
     RRYIYLWIFY ALWEEMEAKD IDRARQVYTE CLKLIPHKKF TFAKVWLMKA QFEVRQLNLQ
     AARKTLGQAI GMCPKDKLFR GYIDLERQLF EFVRCRTLYE KQIEWNPSNS QSWIQYAELE
     RGLDDTERAR AIYELGIDQP TLDMPELVWK AYIDFEDDEG EYERERQLYE RLLQKTDHVK
     VWINYARFEI NVPDEEEEEE EEERPISDEA KRRARAVFER AHRVFKEKEL KEERVELLNA
     WRAFEHTHGS PEDIDKIEKQ MPRRVKKRRK LDDDRYEEYM DYVFPADDQS AANLSKLLRM
     AHQWKQETAG GQQ