ID   CLF1_KLULA              Reviewed;         684 AA.
AC   Q6CJK2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Pre-mRNA-splicing factor CLF1;
GN   Name=CLF1; OrderedLocusNames=KLLA0F17996g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       Required for the spliceosome assembly and initiation of the DNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98595.1; -; Genomic_DNA.
DR   RefSeq; XP_455887.1; XM_455887.1.
DR   AlphaFoldDB; Q6CJK2; -.
DR   SMR; Q6CJK2; -.
DR   STRING; 28985.XP_455887.1; -.
DR   EnsemblFungi; CAG98595; CAG98595; KLLA0_F17996g.
DR   GeneID; 2895583; -.
DR   KEGG; kla:KLLA0_F17996g; -.
DR   eggNOG; KOG1915; Eukaryota.
DR   HOGENOM; CLU_011554_1_0_1; -.
DR   InParanoid; Q6CJK2; -.
DR   OMA; HIKVWIS; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR   GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR   Gene3D; 1.25.40.10; -; 4.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF02184; HAT; 1.
DR   SMART; SM00386; HAT; 12.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..684
FT                   /note="Pre-mRNA-splicing factor CLF1"
FT                   /id="PRO_0000205746"
FT   REPEAT          43..75
FT                   /note="HAT 1"
FT   REPEAT          77..109
FT                   /note="HAT 2"
FT   REPEAT          111..143
FT                   /note="HAT 3"
FT   REPEAT          145..176
FT                   /note="HAT 4"
FT   REPEAT          178..209
FT                   /note="HAT 5"
FT   REPEAT          211..251
FT                   /note="HAT 6"
FT   REPEAT          253..285
FT                   /note="HAT 7"
FT   REPEAT          295..327
FT                   /note="HAT 8"
FT   REPEAT          332..364
FT                   /note="HAT 9"
FT   REPEAT          374..410
FT                   /note="HAT 10"
FT   REPEAT          412..443
FT                   /note="HAT 11"
FT   REPEAT          445..477
FT                   /note="HAT 12"
FT   REPEAT          518..550
FT                   /note="HAT 13"
FT   REPEAT          584..622
FT                   /note="HAT 14"
SQ   SEQUENCE   684 AA;  81230 MW;  E085240FA7DBB053 CRC64;
     MGDNSLSNEA ITADNILKDA FSQKKQIAAT TKADILDLEE LKDWQRRKRT EYETVLKRNR
     LDLRQWMRYA QFEFDQKDIR RARSIYERAL LVDHGFIPLW IQYIDSEIKW KNINHARNLL
     DRATNALPRV DKLWFKYLLL EESLGNQGIV RGIYTRWCSF EPGPDAWDSF IEFETRCLNF
     ENVRNIYSKF VLVHPQIDTW LKWVRFEQTH GDISSVRTVF SFALDTLTSF SGTPLVDIER
     VIGSFASWEA SQGEYERSRT LYRLAVERWP ISEALKEQQI QFEKKFGSSK NMEDIVIAKR
     KAEYEQYLKS DPYHYSTWWV YIDLVEEKYQ EQLTSAFQSF IELAKPKSLV KDSSWKRYIR
     ICVRYLVYLE LTINDLPTIR SVYQDILDII PHKKFTFGKL WIMYAEFEIR QNNLLKARKI
     LGVSLGKSPK PKVFKYYINL EIRLKEFDRV RKLYEKYIDF NPSSVQSWLD YAELEENLGD
     EDRSRGIYDI SMSNNVGLSE SDQLIVIQRY IAFETDAAEY EKARELYEKY LILSRYDVNI
     WINQALFEST IPTETQLIAY QQSHQDGNFD DDGEEEFSFE ITPENKHHTR AIFEKAISYF
     KEHNEDKKRQ QVLQSLLEYE KVHGNQETLE KVNARQPSLV REKVTIDNIE QESYKLDFPD
     DRVAQPPIAR NLLALAKQWE KNSS