CLF1_MAGO7
ID CLF1_MAGO7 Reviewed; 691 AA.
AC Q527H0; A4RQ48; G4MPG7;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Pre-mRNA-splicing factor CLF1;
GN Name=CLF1; ORFNames=MGG_05720;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC Required for the spliceosome assembly and initiation of the DNA
CC replication (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR EMBL; CM001231; EHA58010.1; -; Genomic_DNA.
DR RefSeq; XP_003710622.1; XM_003710574.1.
DR AlphaFoldDB; Q527H0; -.
DR SMR; Q527H0; -.
DR STRING; 318829.MGG_05720T0; -.
DR PRIDE; Q527H0; -.
DR EnsemblFungi; MGG_05720T0; MGG_05720T0; MGG_05720.
DR GeneID; 2675972; -.
DR KEGG; mgr:MGG_05720; -.
DR VEuPathDB; FungiDB:MGG_05720; -.
DR eggNOG; KOG1915; Eukaryota.
DR HOGENOM; CLU_011554_1_0_1; -.
DR InParanoid; Q527H0; -.
DR OMA; HIKVWIS; -.
DR OrthoDB; 355408at2759; -.
DR Proteomes; UP000009058; Chromosome 1.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IEA:EnsemblFungi.
DR GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR Gene3D; 1.25.40.10; -; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246; PTHR11246; 1.
DR Pfam; PF02184; HAT; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00386; HAT; 15.
DR SUPFAM; SSF48452; SSF48452; 4.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome.
FT CHAIN 1..691
FT /note="Pre-mRNA-splicing factor CLF1"
FT /id="PRO_0000205747"
FT REPEAT 52..84
FT /note="HAT 1"
FT REPEAT 86..118
FT /note="HAT 2"
FT REPEAT 120..152
FT /note="HAT 3"
FT REPEAT 154..185
FT /note="HAT 4"
FT REPEAT 187..218
FT /note="HAT 5"
FT REPEAT 220..258
FT /note="HAT 6"
FT REPEAT 260..294
FT /note="HAT 7"
FT REPEAT 304..336
FT /note="HAT 8"
FT REPEAT 338..372
FT /note="HAT 9"
FT REPEAT 382..418
FT /note="HAT 10"
FT REPEAT 420..451
FT /note="HAT 11"
FT REPEAT 453..485
FT /note="HAT 12"
FT REPEAT 487..521
FT /note="HAT 13"
FT REPEAT 523..554
FT /note="HAT 14"
FT REPEAT 574..612
FT /note="HAT 15"
FT REPEAT 617..650
FT /note="HAT 16"
SQ SEQUENCE 691 AA; 82325 MW; DD231D256AEEEBC2 CRC64;
MEASRGPPRV KNKAAAPVQI SAEQLLREAT DRQEEALQKP TQRFEDLEEL HEYQGRKRKE
FESYCQRSGF NLKNWLQYAQ WELEQKEYAR SRSVFERALN LHANKVTLWI RYVEAELKSR
NINFARNLLD RAVTHLPRVD KLWYKYVWVE EMLGNIPGVR QVFERWMEWQ PDEAAWSAFI
KLEQRYGEYD RAREIFTRFT MVHPEPRNWI KWSKFEEEYG TSDRVREVFE RAIEELSKYG
DEFVEERLFI AYARYEAKLH DLDRARAIYK FGLENLPRSK AMLLHKEYTT FEKQYGDREG
VEDVVLSKRR RHYEDLVREN PKNYDVWFDY ARLEEASGDI DRTREVYEKA IAQVPPTQAK
RHWRRYIYLW IFFALWEETE AKNPERARQV YDTCLKLIPH RTFTFAKVWM HKAHFEIRQG
DLAAARKTLG RAIGMCPKDR LFKGYIEMEQ KLYEFGRCRI LYEKHIAYNP ANCSTWVKWA
ELERGLDDLD RARAILDMGI AQPVLDMPEV VWKSYIDFEE EEGEYDKTRS LYERLLDKAD
HPKVWISYAQ FEINIPEEAG EGADEEQEQP VSDEAKARAR RVFERAHQGF KDKEMKAERV
SILNAWLVFE KTHGSAEDIE KIEKQMPRRT KKKRKLDDDT WEEYVDYIFP ADEQVGKNLM
NMMAKARARK QAEAEAAAKA AAADDGGESG E