位置:首页 > 蛋白库 > CLF1_NEUCR
CLF1_NEUCR
ID   CLF1_NEUCR              Reviewed;         695 AA.
AC   Q7SGD2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Pre-mRNA-splicing factor clf-1;
GN   Name=clf-1; ORFNames=NCU02717;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       Required for the spliceosome assembly and initiation of the DNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM002236; EAA35866.1; -; Genomic_DNA.
DR   RefSeq; XP_965102.1; XM_960009.2.
DR   AlphaFoldDB; Q7SGD2; -.
DR   SMR; Q7SGD2; -.
DR   STRING; 5141.EFNCRP00000002061; -.
DR   EnsemblFungi; EAA35866; EAA35866; NCU02717.
DR   GeneID; 3881267; -.
DR   KEGG; ncr:NCU02717; -.
DR   VEuPathDB; FungiDB:NCU02717; -.
DR   HOGENOM; CLU_011554_1_0_1; -.
DR   InParanoid; Q7SGD2; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR   GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 4.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF02184; HAT; 1.
DR   SMART; SM00386; HAT; 15.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..695
FT                   /note="Pre-mRNA-splicing factor clf-1"
FT                   /id="PRO_0000205748"
FT   REPEAT          52..84
FT                   /note="HAT 1"
FT   REPEAT          86..118
FT                   /note="HAT 2"
FT   REPEAT          120..152
FT                   /note="HAT 3"
FT   REPEAT          154..185
FT                   /note="HAT 4"
FT   REPEAT          187..218
FT                   /note="HAT 5"
FT   REPEAT          220..259
FT                   /note="HAT 6"
FT   REPEAT          261..295
FT                   /note="HAT 7"
FT   REPEAT          305..337
FT                   /note="HAT 8"
FT   REPEAT          339..373
FT                   /note="HAT 9"
FT   REPEAT          383..419
FT                   /note="HAT 10"
FT   REPEAT          421..452
FT                   /note="HAT 11"
FT   REPEAT          454..486
FT                   /note="HAT 12"
FT   REPEAT          488..522
FT                   /note="HAT 13"
FT   REPEAT          524..555
FT                   /note="HAT 14"
FT   REPEAT          578..616
FT                   /note="HAT 15"
FT   REPEAT          621..654
FT                   /note="HAT 16"
SQ   SEQUENCE   695 AA;  82733 MW;  415836038BCCC568 CRC64;
     MESSRGPPRV KNKAPAPVQI SAEQLLREAV DRQEVNLQTP TQRFADLEEL KEYQGRKRKE
     FEDYVRRNRV RLSNWLQYAQ WELEQKEFAR ARSVFERALD VHPNNTQLWI RYVQAEIKNR
     NINHARNLLD RAVTRLPRVT SLWYQYLYVM EMLGDIPGTR QVFDRWMKWQ PDEQAWSAYI
     RLEKRYGEFD RAREIFRAFT AVHPEPRTWL KWAKFEEEYG TSDTVREVFQ TAIQTIAETL
     GDDAVDERIF IAFARYEARL REYERARAIY KFGLDNLPRS KSMTLHAHYT TFEKQFGDKE
     GVEDVILTKR RRLYEEQVKE NAKNYDVWFD FARLEESGGD VDRTREVYER AIAQVPPTQE
     KRHWRRYIFL FLFYAIWEER ETKDIGRARQ IYDTCLNLIP HKKFTFAKVW VAKAHFEIRQ
     GQLTTARKTL GRAIGMCPKD KIFKEYILLE QKLYEFERCR TLYEKHVMYN PANCQTWIKW
     AELERGLDDL ERTRAIFELA VSQPILDMPE VVWKAYIDFE EEEGEYERTR ALYERLLEKA
     DHPKVWISYA QFEINIPDEA EEEEETEEEV EEKPVSEEAK ARARKIFERA HKSMKERELK
     AERVSLLNAW LAFEKTHGSA EDIEKIQKQM PRKTKKKRKL EDDTWEEYVD YIFPADDQQT
     KNLSSLLAMA NAWKQQAAGG AGGAAVDEAA QGGSS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024