CLF1_NEUCR
ID CLF1_NEUCR Reviewed; 695 AA.
AC Q7SGD2;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Pre-mRNA-splicing factor clf-1;
GN Name=clf-1; ORFNames=NCU02717;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC Required for the spliceosome assembly and initiation of the DNA
CC replication (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM002236; EAA35866.1; -; Genomic_DNA.
DR RefSeq; XP_965102.1; XM_960009.2.
DR AlphaFoldDB; Q7SGD2; -.
DR SMR; Q7SGD2; -.
DR STRING; 5141.EFNCRP00000002061; -.
DR EnsemblFungi; EAA35866; EAA35866; NCU02717.
DR GeneID; 3881267; -.
DR KEGG; ncr:NCU02717; -.
DR VEuPathDB; FungiDB:NCU02717; -.
DR HOGENOM; CLU_011554_1_0_1; -.
DR InParanoid; Q7SGD2; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045075; Syf1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR11246; PTHR11246; 1.
DR Pfam; PF02184; HAT; 1.
DR SMART; SM00386; HAT; 15.
DR SUPFAM; SSF48452; SSF48452; 2.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Spliceosome.
FT CHAIN 1..695
FT /note="Pre-mRNA-splicing factor clf-1"
FT /id="PRO_0000205748"
FT REPEAT 52..84
FT /note="HAT 1"
FT REPEAT 86..118
FT /note="HAT 2"
FT REPEAT 120..152
FT /note="HAT 3"
FT REPEAT 154..185
FT /note="HAT 4"
FT REPEAT 187..218
FT /note="HAT 5"
FT REPEAT 220..259
FT /note="HAT 6"
FT REPEAT 261..295
FT /note="HAT 7"
FT REPEAT 305..337
FT /note="HAT 8"
FT REPEAT 339..373
FT /note="HAT 9"
FT REPEAT 383..419
FT /note="HAT 10"
FT REPEAT 421..452
FT /note="HAT 11"
FT REPEAT 454..486
FT /note="HAT 12"
FT REPEAT 488..522
FT /note="HAT 13"
FT REPEAT 524..555
FT /note="HAT 14"
FT REPEAT 578..616
FT /note="HAT 15"
FT REPEAT 621..654
FT /note="HAT 16"
SQ SEQUENCE 695 AA; 82733 MW; 415836038BCCC568 CRC64;
MESSRGPPRV KNKAPAPVQI SAEQLLREAV DRQEVNLQTP TQRFADLEEL KEYQGRKRKE
FEDYVRRNRV RLSNWLQYAQ WELEQKEFAR ARSVFERALD VHPNNTQLWI RYVQAEIKNR
NINHARNLLD RAVTRLPRVT SLWYQYLYVM EMLGDIPGTR QVFDRWMKWQ PDEQAWSAYI
RLEKRYGEFD RAREIFRAFT AVHPEPRTWL KWAKFEEEYG TSDTVREVFQ TAIQTIAETL
GDDAVDERIF IAFARYEARL REYERARAIY KFGLDNLPRS KSMTLHAHYT TFEKQFGDKE
GVEDVILTKR RRLYEEQVKE NAKNYDVWFD FARLEESGGD VDRTREVYER AIAQVPPTQE
KRHWRRYIFL FLFYAIWEER ETKDIGRARQ IYDTCLNLIP HKKFTFAKVW VAKAHFEIRQ
GQLTTARKTL GRAIGMCPKD KIFKEYILLE QKLYEFERCR TLYEKHVMYN PANCQTWIKW
AELERGLDDL ERTRAIFELA VSQPILDMPE VVWKAYIDFE EEEGEYERTR ALYERLLEKA
DHPKVWISYA QFEINIPDEA EEEEETEEEV EEKPVSEEAK ARARKIFERA HKSMKERELK
AERVSLLNAW LAFEKTHGSA EDIEKIQKQM PRKTKKKRKL EDDTWEEYVD YIFPADDQQT
KNLSSLLAMA NAWKQQAAGG AGGAAVDEAA QGGSS
