ID   CLF1_PARBR              Reviewed;         677 AA.
AC   Q5K654;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Pre-mRNA-splicing factor CLF1;
GN   Name=CLF1;
OS   Paracoccidioides brasiliensis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=121759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 32071 / IVIC Pb73 / C81;
RX   PubMed=16422297; DOI=10.1080/13693780500129673;
RA   Reinoso C., Nino-Vega G., San-Blast G., Dominguez A.;
RT   "Random sequencing of Paracoccidioides brasiliensis genes.";
RL   Med. Mycol. 43:681-689(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       Required for the spliceosome assembly and initiation of the DNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; AF443189; AAQ04633.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5K654; -.
DR   SMR; Q5K654; -.
DR   PRIDE; Q5K654; -.
DR   VEuPathDB; FungiDB:PABG_03315; -.
DR   VEuPathDB; FungiDB:PADG_01877; -.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF02184; HAT; 2.
DR   SMART; SM00386; HAT; 15.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Repeat; Spliceosome.
FT   CHAIN           1..677
FT                   /note="Pre-mRNA-splicing factor CLF1"
FT                   /id="PRO_0000205749"
FT   REPEAT          52..84
FT                   /note="HAT 1"
FT   REPEAT          86..118
FT                   /note="HAT 2"
FT   REPEAT          120..152
FT                   /note="HAT 3"
FT   REPEAT          154..185
FT                   /note="HAT 4"
FT   REPEAT          187..218
FT                   /note="HAT 5"
FT   REPEAT          220..255
FT                   /note="HAT 6"
FT   REPEAT          257..291
FT                   /note="HAT 7"
FT   REPEAT          301..333
FT                   /note="HAT 8"
FT   REPEAT          335..369
FT                   /note="HAT 9"
FT   REPEAT          379..415
FT                   /note="HAT 10"
FT   REPEAT          417..448
FT                   /note="HAT 11"
FT   REPEAT          450..482
FT                   /note="HAT 12"
FT   REPEAT          484..518
FT                   /note="HAT 13"
FT   REPEAT          520..551
FT                   /note="HAT 14"
FT   REPEAT          570..608
FT                   /note="HAT 15"
FT   REPEAT          613..646
FT                   /note="HAT 16"
SQ   SEQUENCE   677 AA;  81798 MW;  42FE39F84E64C7D1 CRC64;
     MEASRGPPRV KNKAPAPQQI SAEQLLREAV DRQEPALQAP TQRFADLEEL HEYQGRKRKE
     FEDYVRRNRI SMNNWMRYAQ WELEQKEFRR ARSVFERALD VDPTAVVLWI RYIEAEMKTR
     NINHARNLLD RAVTIYSRVD KLWYKYVYME EMLGNIPGTR QVFERWMSWE PDEGAWGAYI
     KLEKRYNEFD RVRAIFERFT VVHPEPKNWI KWARFEEEYG TSDMVREVYG LAIETLGEDF
     MDEKLFIAYA RYEAKLKEFE RARAIYKYAL DRLPRAKSVA LHKAYTTFEK QFGDREGVED
     VILSKRRVQY EEQIKENPKN YDIWFDFVRL EESSGDVERV RDVYERAIAQ MPPSQEKRHW
     RRYIYLWIFY ALWEELEAKD MERAHQIYQE CIRLIPHKKF TFAKIWLMKA QFEIRQMDLQ
     AARKTLGHAI GACPKDKLFK GYIDLERQLF EFVRCRKLFE KQIEWSPSNC QAWIKFAELE
     RGLDDIDRAR AIYELGISQP VLDMPELLWK SYIDFEEYEG EYDRTRALYE RLLEKTNHVK
     VWINFARFEI NIPEGEEEDE DEEEKPVSEE AKRRARMVFE RAHKVFKEKE MKEERVALLN
     AWKSFEQTHG SPDDIAKIER QMPSKVKKRR KLDDDRYEEY LDYMFPADDE SSAKLSQILQ
     MAHKWKKEQA SKASKET