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CLF1_USTMA
ID   CLF1_USTMA              Reviewed;         781 AA.
AC   Q4PB37; A0A0D1E0D3;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Pre-mRNA-splicing factor CLF1;
GN   Name=CLF1; ORFNames=UMAG_02676;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       Required for the spliceosome assembly and initiation of the DNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; CM003145; KIS69336.1; -; Genomic_DNA.
DR   RefSeq; XP_011389057.1; XM_011390755.1.
DR   AlphaFoldDB; Q4PB37; -.
DR   SMR; Q4PB37; -.
DR   STRING; 5270.UM02676P0; -.
DR   EnsemblFungi; KIS69336; KIS69336; UMAG_02676.
DR   GeneID; 23563367; -.
DR   KEGG; uma:UMAG_02676; -.
DR   VEuPathDB; FungiDB:UMAG_02676; -.
DR   eggNOG; KOG1915; Eukaryota.
DR   HOGENOM; CLU_011554_1_0_1; -.
DR   InParanoid; Q4PB37; -.
DR   OMA; HIKVWIS; -.
DR   OrthoDB; 355408at2759; -.
DR   Proteomes; UP000000561; Chromosome 6.
DR   GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblFungi.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR   GO; GO:0000354; P:cis assembly of pre-catalytic spliceosome; IEA:EnsemblFungi.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 4.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF02184; HAT; 1.
DR   SMART; SM00386; HAT; 13.
DR   SUPFAM; SSF48452; SSF48452; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..781
FT                   /note="Pre-mRNA-splicing factor CLF1"
FT                   /id="PRO_0000205751"
FT   REPEAT          50..82
FT                   /note="HAT 1"
FT   REPEAT          84..116
FT                   /note="HAT 2"
FT   REPEAT          118..150
FT                   /note="HAT 3"
FT   REPEAT          152..183
FT                   /note="HAT 4"
FT   REPEAT          185..216
FT                   /note="HAT 5"
FT   REPEAT          218..257
FT                   /note="HAT 6"
FT   REPEAT          259..293
FT                   /note="HAT 7"
FT   REPEAT          308..340
FT                   /note="HAT 8"
FT   REPEAT          357..391
FT                   /note="HAT 9"
FT   REPEAT          401..437
FT                   /note="HAT 10"
FT   REPEAT          439..470
FT                   /note="HAT 11"
FT   REPEAT          472..504
FT                   /note="HAT 12"
FT   REPEAT          506..547
FT                   /note="HAT 13"
FT   REPEAT          549..580
FT                   /note="HAT 14"
FT   REPEAT          628..665
FT                   /note="HAT 15"
FT   REGION          586..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          724..781
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        600..620
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        727..747
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        763..781
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   781 AA;  91290 MW;  5741179FA14BA4A0 CRC64;
     MSRSAPRIKN RAPAPIQISA EQLLREAQER QEAPASAPVQ KIEDYEELEE YRGRRRSEFE
     DRLRRNGLNM STWIKYASWE ASQGEMDRCR SIYERALDVE PHHLPLWLRY TEQELKMRNV
     QHARNLYDRA VSILPRIDQL WYKYVHLEEL LGNIPGTRQV FERWMKWEPE EKAWHAYINL
     EVRYDELDRA SAIWERCVTC HPVPKQWIRW AKFEEDRGNL EKARIVFQMA LDYIGEDEDA
     MEKAQSVFTA FAKMETRLKE YERARVIYKY ALERLPRSKS EGIYSSYTRF EKQFGTMNSV
     EDTVIGKRRI QYEEELAAQE AGGAPADYDT WFDYSRLEED AYRALLATGG SQDQLQQAVK
     RVREVYERAI AQVPSSQEKR DWRRYIFLWL RYALFEEIDT RDYDRTREIY KAAIALVPHR
     RFTFAKLWVQ YARFEVRRLE LTAARKILGA AIGMAPKLKL FSSYIELEVS LKEFDRARKI
     YEKALEWDPT NSQTWVRFAE LEKNLFDTDR ARALFELGVG QAEGGEASGG LDMPEIVWKA
     YIDFEFEERE WEKVDALYER LLAKSGHVKV WISYALSKIN RATAIEEDED EEDDDHDHDD
     DMAATPSREL TEEEEALRQQ RRSALASSAR EIFQRAYDNL KSRSLKDERV ALLESWKSFE
     QQHGSAETLS RVEAKFPRVV KKRRQVEDSA DGAMEEYYDL IFPDDQDEGK GAFKLLQMAH
     AWRAAQAAKE QQQQQQQSSS AETGASASAG AGATGDDVRD EESIGIAIDD DQEQDASGEE
     A
 
 
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