ID   CLF1_YARLI              Reviewed;         676 AA.
AC   Q6C186;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Pre-mRNA-splicing factor CLF1;
GN   Name=CLF1; OrderedLocusNames=YALI0F18392g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing and cell cycle progression.
CC       Required for the spliceosome assembly and initiation of the DNA
CC       replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the crooked-neck family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78385.1; -; Genomic_DNA.
DR   RefSeq; XP_505576.1; XM_505576.1.
DR   AlphaFoldDB; Q6C186; -.
DR   SMR; Q6C186; -.
DR   STRING; 4952.CAG78385; -.
DR   PRIDE; Q6C186; -.
DR   EnsemblFungi; CAG78385; CAG78385; YALI0_F18392g.
DR   GeneID; 2907810; -.
DR   KEGG; yli:YALI0F18392g; -.
DR   VEuPathDB; FungiDB:YALI0_F18392g; -.
DR   HOGENOM; CLU_011554_1_0_1; -.
DR   InParanoid; Q6C186; -.
DR   OMA; HIKVWIS; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   GO; GO:0000245; P:spliceosomal complex assembly; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 5.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11246; PTHR11246; 1.
DR   Pfam; PF02184; HAT; 1.
DR   SMART; SM00386; HAT; 13.
DR   SUPFAM; SSF48452; SSF48452; 3.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Spliceosome.
FT   CHAIN           1..676
FT                   /note="Pre-mRNA-splicing factor CLF1"
FT                   /id="PRO_0000205752"
FT   REPEAT          46..78
FT                   /note="HAT 1"
FT   REPEAT          80..112
FT                   /note="HAT 2"
FT   REPEAT          114..146
FT                   /note="HAT 3"
FT   REPEAT          148..179
FT                   /note="HAT 4"
FT   REPEAT          181..212
FT                   /note="HAT 5"
FT   REPEAT          215..255
FT                   /note="HAT 6"
FT   REPEAT          257..291
FT                   /note="HAT 7"
FT   REPEAT          301..333
FT                   /note="HAT 8"
FT   REPEAT          336..369
FT                   /note="HAT 9"
FT   REPEAT          379..415
FT                   /note="HAT 10"
FT   REPEAT          417..449
FT                   /note="HAT 11"
FT   REPEAT          451..483
FT                   /note="HAT 12"
FT   REPEAT          485..519
FT                   /note="HAT 13"
FT   REPEAT          521..553
FT                   /note="HAT 14"
FT   REPEAT          576..614
FT                   /note="HAT 15"
FT   REPEAT          620..652
FT                   /note="HAT 16"
FT   REGION          616..636
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   676 AA;  80058 MW;  DE8105AD318A0566 CRC64;
     MEGRVKNKAP AALQISAEQI LLEAYERKET PLQQTEQIAD LEELAEYQGR KRQEYEGALR
     RNRLNTGQWM RYAQWELEQR EFARARSVFE RALEVNSTHV PTWIRYIQCE LKEKNINHAR
     NLLDRAVTLL PRVDKLWFTY VATEETLGNI AGCRAVFERW MHWRPPVTAW AAYVNMEKRY
     REFDRARGIL RRYVTVHPGA PAWNKWAKFE MEAGNRDTVR EVYALGIDTL VEMAHGGVDF
     LDESLLAGWA SFETRHREYE RARALYTYGL EKLPKSKSAK LYADYTAFEK QYGAKEGIEN
     VVLTKRRSKY EDQLKEDPAD YDTWFSYITL GQESGLEADQ IREIFERAVS NVPPHSKRLW
     RRYIFLWIKY AIWEELENKE VEKAREIYKT CISIIPHKKF TFAKVWLLWA KFEIRHGNLP
     EARKILGRGL GMSGGKPALY KGYIALEAKL REFDRCRKLY DKYVEKFAEF AAPWMEYAEL
     EQMLGDEERA RAIFELAVSQ PEMEMPELVW KRFIEFEAEE ENYDRARAIY RQLLDRTHGH
     IKVWISFAQF EVTVPAEDQE LQYNDEGEAE IEVTEEAKAR ARSIFGEAWD ALKAANKREE
     RVVLFESWRE FEEEHGDDKS KADLDKRKPT PVKKKRKLED GTFEEYIDYV FPTDEEDKSF
     SKLLENARKW KLQNQS