CLF2A_MOUSE
ID CLF2A_MOUSE Reviewed; 169 AA.
AC Q9DAR1; Q811V3; Q9CVR4;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 2A;
DE AltName: Full=Chemokine-like factor superfamily member 2A;
GN Name=Cmtm2a; Synonyms=Cklfsf2a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RA Li T., Han W., Yang T., Ma D.;
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Rui M., Han W., Ma D.;
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Han W., Li T., Tan Y., Shi S., Ding P., Ma D.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-168 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=1b;
CC IsoId=Q9DAR1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DAR1-2; Sequence=VSP_008255;
CC Name=3; Synonyms=1a;
CC IsoId=Q9DAR1-3; Sequence=VSP_008253, VSP_008254;
CC Name=4;
CC IsoId=Q9DAC0-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AY162281; AAO34102.1; -; mRNA.
DR EMBL; AY172740; AAO17718.1; -; mRNA.
DR EMBL; AY241871; AAP33493.1; -; mRNA.
DR EMBL; AK005603; BAB24146.1; -; mRNA.
DR EMBL; AK006874; BAB24775.1; -; mRNA.
DR EMBL; BC049747; AAH49747.1; -; mRNA.
DR CCDS; CCDS40451.1; -. [Q9DAR1-1]
DR RefSeq; NP_081298.1; NM_027022.4. [Q9DAR1-1]
DR AlphaFoldDB; Q9DAR1; -.
DR BioGRID; 215972; 1.
DR STRING; 10090.ENSMUSP00000034344; -.
DR TCDB; 1.A.64.5.6; the plasmolipin (plasmolipin) family.
DR PaxDb; Q9DAR1; -.
DR PRIDE; Q9DAR1; -.
DR Ensembl; ENSMUST00000034344; ENSMUSP00000034344; ENSMUSG00000074127. [Q9DAR1-1]
DR GeneID; 73381; -.
DR KEGG; mmu:73381; -.
DR UCSC; uc009nah.1; mouse. [Q9DAR1-1]
DR UCSC; uc009naj.1; mouse. [Q9DAR1-2]
DR CTD; 73381; -.
DR MGI; MGI:2447160; Cmtm2a.
DR VEuPathDB; HostDB:ENSMUSG00000074127; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00390000005715; -.
DR HOGENOM; CLU_106771_0_0_1; -.
DR InParanoid; Q9DAR1; -.
DR OMA; MEISIFC; -.
DR OrthoDB; 1328400at2759; -.
DR PhylomeDB; Q9DAR1; -.
DR TreeFam; TF338711; -.
DR BioGRID-ORCS; 73381; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q9DAR1; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9DAR1; protein.
DR Bgee; ENSMUSG00000074127; Expressed in spermatid and 16 other tissues.
DR ExpressionAtlas; Q9DAR1; baseline and differential.
DR Genevisible; Q9DAR1; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IPI:MGI.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; IDA:MGI.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:2000224; P:regulation of testosterone biosynthetic process; IDA:MGI.
DR InterPro; IPR008253; Marvel.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chemotaxis; Cytokine; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..169
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 2A"
FT /id="PRO_0000186099"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 40..162
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT VAR_SEQ 97..101
FT /note="YIPFV -> SEALG (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_008253"
FT VAR_SEQ 102..169
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_008254"
FT VAR_SEQ 107..168
FT /note="DIFNSLFSCVFLGGGIYFAFKARRLLPKPYLTAMILMGAAAICSFIDMLLQF
FT QHFRGLRLRK -> LLVSRDPSVLRKTTSTGGKEKRMQMRTFESRTHRRQSEKDGARVL
FT SEGAEEISFSLVKGKAR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_008255"
SQ SEQUENCE 169 AA; 19553 MW; 2F0ABFD48221B130 CRC64;
MAAPIKFPFR PRGGQPREDT TPKRGLRRYL LELKESNKEF WLSGHAVFKL LSLGCMISAL
DYFETMLPHP VLILLICMEA AICIFFIFLN TLAINRYIPF VFWPMADIFN SLFSCVFLGG
GIYFAFKARR LLPKPYLTAM ILMGAAAICS FIDMLLQFQH FRGLRLRKW
