CLF2B_MOUSE
ID CLF2B_MOUSE Reviewed; 210 AA.
AC Q9DAC0;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=CKLF-like MARVEL transmembrane domain-containing protein 2B;
DE AltName: Full=Chemokine-like factor superfamily member 2B;
GN Name=Cmtm2b; Synonyms=Cklfsf2b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RA Han W., Li T., Tan Y., Shi S., Ding P., Ma D.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=4;
CC IsoId=Q9DAC0-1; Sequence=Displayed;
CC Name=1; Synonyms=1b;
CC IsoId=Q9DAR1-1; Sequence=External;
CC Name=2;
CC IsoId=Q9DAR1-2; Sequence=External;
CC Name=3; Synonyms=1a;
CC IsoId=Q9DAR1-3; Sequence=External;
CC -!- SIMILARITY: Belongs to the chemokine-like factor family. {ECO:0000305}.
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DR EMBL; AY162282; AAO34103.1; -; mRNA.
DR EMBL; AY241872; AAP33494.1; -; mRNA.
DR EMBL; AK005970; BAB24346.1; -; mRNA.
DR EMBL; BC060997; AAH60997.1; -; mRNA.
DR CCDS; CCDS22576.1; -. [Q9DAC0-1]
DR RefSeq; NP_082800.1; NM_028524.3. [Q9DAC0-1]
DR AlphaFoldDB; Q9DAC0; -.
DR STRING; 10090.ENSMUSP00000043127; -.
DR TCDB; 1.A.64.5.7; the plasmolipin (plasmolipin) family.
DR PhosphoSitePlus; Q9DAC0; -.
DR PaxDb; Q9DAC0; -.
DR PRIDE; Q9DAC0; -.
DR ProteomicsDB; 285492; -. [Q9DAC0-1]
DR Ensembl; ENSMUST00000041973; ENSMUSP00000043127; ENSMUSG00000035785. [Q9DAC0-1]
DR GeneID; 75502; -.
DR KEGG; mmu:75502; -.
DR UCSC; uc009nal.2; mouse. [Q9DAC0-1]
DR CTD; 75502; -.
DR MGI; MGI:2447311; Cmtm2b.
DR VEuPathDB; HostDB:ENSMUSG00000035785; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00390000005715; -.
DR HOGENOM; CLU_106771_0_0_1; -.
DR InParanoid; Q9DAC0; -.
DR OMA; FFIIIYT; -.
DR OrthoDB; 1328400at2759; -.
DR PhylomeDB; Q9DAC0; -.
DR TreeFam; TF338711; -.
DR BioGRID-ORCS; 75502; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Cmtm2b; mouse.
DR PRO; PR:Q9DAC0; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9DAC0; protein.
DR Bgee; ENSMUSG00000035785; Expressed in seminiferous tubule of testis and 13 other tissues.
DR ExpressionAtlas; Q9DAC0; baseline and differential.
DR Genevisible; Q9DAC0; MM.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR PROSITE; PS51225; MARVEL; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chemotaxis; Cytokine; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..210
FT /note="CKLF-like MARVEL transmembrane domain-containing
FT protein 2B"
FT /id="PRO_0000186100"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 35..157
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ SEQUENCE 210 AA; 24366 MW; 795308551CD1AF10 CRC64;
MAAPAPRART GGKKKDERRG FKGYKWEFRD SNKDFWAQGH AECKSLIMIL LIAAMVCFQR
VATHPIVILL LTMELSICAF FFFLYSLAIN RYIPFVFWPM MDLMNDLACS TFLIGGIFFA
LEARRELPVP YLTGMILMGV TAFISIIDLC LQRRQFKSRK LRKFILLTPD RKGKKQDPKL
LLMLAAKEDE EERQRELAEK AKRESMDPGW
