CLG1_YEAST
ID CLG1_YEAST Reviewed; 452 AA.
AC P35190; D6VTU1;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=PHO85 cyclin CLG1;
DE AltName: Full=Cyclin-like G1 protein 1;
GN Name=CLG1; OrderedLocusNames=YGL215W; ORFNames=G1105;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8212900; DOI=10.1002/yea.320090813;
RA Matsumoto Y., Wickner R.B.;
RT "CLG1, a new cyclin-like gene of Saccharomyces cerevisiae.";
RL Yeast 9:929-931(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9290212;
RX DOI=10.1002/(sici)1097-0061(19970915)13:11<1077::aid-yea152>3.0.co;2-y;
RA Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.;
RT "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae
RT chromosome VII.";
RL Yeast 13:1077-1090(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9153757;
RX DOI=10.1002/(sici)1097-0061(199704)13:5<475::aid-yea101>3.0.co;2-0;
RA Feuermann M., Simeonava L., Souciet J.-L., Potier S.;
RT "Analysis of 21.7 kb DNA sequence from the left arm of chromosome VII
RT reveals 11 open reading frames: two correspond to new genes.";
RL Yeast 13:475-477(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [6]
RP INTERACTION WITH PHO85.
RX PubMed=9032248; DOI=10.1128/mcb.17.3.1212;
RA Measday V., Moore L., Retnakaran R., Lee J., Donoviel M., Neiman A.M.,
RA Andrews B.J.;
RT "A family of cyclin-like proteins that interact with the Pho85 cyclin-
RT dependent kinase.";
RL Mol. Cell. Biol. 17:1212-1223(1997).
CC -!- FUNCTION: Cyclin partner of the cyclin-dependent kinase (CDK) PHO85.
CC Has a role in cell integrity and polarized cell growth together with
CC the other PCL1/PCL2 cyclin family members.
CC -!- SUBUNIT: Forms a cyclin-CDK complex with PHO85.
CC -!- INTERACTION:
CC P35190; P17157: PHO85; NbExp=3; IntAct=EBI-4762, EBI-13327;
CC P35190; P10591: SSA1; NbExp=3; IntAct=EBI-4762, EBI-8591;
CC -!- SIMILARITY: Belongs to the cyclin family. PCL1,2 subfamily.
CC {ECO:0000305}.
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DR EMBL; L11612; AAA16919.1; -; mRNA.
DR EMBL; Z72737; CAA96931.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07902.1; -; Genomic_DNA.
DR PIR; S37607; S37607.
DR RefSeq; NP_011300.1; NM_001181080.1.
DR AlphaFoldDB; P35190; -.
DR BioGRID; 33042; 235.
DR ComplexPortal; CPX-1693; CLG1-PHO85 kinase complex.
DR DIP; DIP-1507N; -.
DR IntAct; P35190; 9.
DR MINT; P35190; -.
DR STRING; 4932.YGL215W; -.
DR iPTMnet; P35190; -.
DR PaxDb; P35190; -.
DR PRIDE; P35190; -.
DR EnsemblFungi; YGL215W_mRNA; YGL215W; YGL215W.
DR GeneID; 852657; -.
DR KEGG; sce:YGL215W; -.
DR SGD; S000003183; CLG1.
DR VEuPathDB; FungiDB:YGL215W; -.
DR eggNOG; ENOG502RYK1; Eukaryota.
DR GeneTree; ENSGT00390000000862; -.
DR HOGENOM; CLU_034017_0_0_1; -.
DR InParanoid; P35190; -.
DR OMA; MYYPNYA; -.
DR BioCyc; YEAST:G3O-30691-MON; -.
DR PRO; PR:P35190; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P35190; protein.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:SGD.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IDA:SGD.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0016239; P:positive regulation of macroautophagy; IMP:SGD.
DR GO; GO:0051726; P:regulation of cell cycle; IC:ComplexPortal.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR InterPro; IPR013922; Cyclin_PHO80-like.
DR PANTHER; PTHR15615; PTHR15615; 1.
PE 1: Evidence at protein level;
KW Cyclin; Reference proteome.
FT CHAIN 1..452
FT /note="PHO85 cyclin CLG1"
FT /id="PRO_0000080503"
SQ SEQUENCE 452 AA; 51571 MW; 579CAE1C45A2BE84 CRC64;
MANTFKYYPE TMGNSSGYPI SLPFPKGSAT SAVNVARQLP KYLGHVPSQS VHTQLPSMAS
LGYFNQPSST YYAPPAPLQQ HQQPPILPPP GLMYTSNNNS NVIPPPVQMI RDGQQQPQQS
NQVNGGVSEN LDYDISIMSK FIMENAFVAF NANYSTDDQT TDLFFKGISS VLNATRLPSA
TIFLAIDYLF KYINKLSNGI HSIGGNSINI IYQNTMIAFI LANKFNDDKT FTNNSWSQAT
GILINVINDF ERQWLRIFNW ELYDSAFLYF EFVKNFEIFK QNQLKPAVAV PTLLSPIVNV
GDTRNVNFNL KPTSTNNLLS PVSNYETPML MPHNMFSSPS YQSNSRSEFS SMNGYYNYYN
YNQPRLNYYQ QFPNIYSSPI SETQFDYDFY NFSSQQQQQQ QKQHSLLPAA PQLPPPHVHN
QSYGHHLGWK SMDDTINHSR FERNYFPYSA VY
