CLGR_MYCTO
ID CLGR_MYCTO Reviewed; 112 AA.
AC P9WMH6; F2GPH7; O33287; Q7D6N6;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=Transcriptional regulator ClgR {ECO:0000305};
GN Name=clgR; OrderedLocusNames=MT2816;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
RN [2]
RP FUNCTION, AND INDUCTION.
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=19376862; DOI=10.1128/jb.00064-09;
RA Mehra S., Kaushal D.;
RT "Functional genomics reveals extended roles of the Mycobacterium
RT tuberculosis stress response factor sigmaH.";
RL J. Bacteriol. 191:3965-3980(2009).
RN [3]
RP FUNCTION, AND INDUCTION.
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=20701538; DOI=10.1086/654820;
RA Mehra S., Dutta N.K., Mollenkopf H.J., Kaushal D.;
RT "Mycobacterium tuberculosis MT2816 encodes a key stress-response
RT regulator.";
RL J. Infect. Dis. 202:943-953(2010).
RN [4]
RP FUNCTION.
RX PubMed=24705585; DOI=10.1371/journal.pone.0093604;
RA McGillivray A., Golden N.A., Gautam U.S., Mehra S., Kaushal D.;
RT "The Mycobacterium tuberculosis Rv2745c plays an important role in
RT responding to redox stress.";
RL PLoS ONE 9:e93604-e93604(2014).
RN [5]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=25422323; DOI=10.1074/jbc.m114.615534;
RA McGillivray A., Golden N.A., Kaushal D.;
RT "The Mycobacterium tuberculosis Clp gene regulator is required for in vitro
RT reactivation from hypoxia-induced dormancy.";
RL J. Biol. Chem. 290:2351-2367(2015).
CC -!- FUNCTION: Key stress-response regulator that plays an important role in
CC multiple regulatory networks in response to different stress conditions
CC (PubMed:20701538, PubMed:24705585). Required to manage host-derived
CC stress during infection (PubMed:20701538). Plays a role during hypoxia
CC and reaeration (PubMed:25422323). Controls the expression of many genes
CC involved in heat shock, virulence, lipid metabolism, transport or
CC regulation, including clpP1, clpP2, clpC1, hsp, groES, otsA, pknD, prcA
CC and prcB (PubMed:19376862, PubMed:20701538). May function by protecting
CC intracellular redox potential and by inducing the expression of
CC trehalose, a constituent of cell walls that is important for defense
CC against cell-surface and oxidative stress (PubMed:20701538). Also
CC performs different functions during stress response and is important
CC for the pathogenicity of M.tuberculosis in vivo, regardless of the
CC induction of the Clp proteolytic pathway (PubMed:24705585). May
CC directly activate SigE and/or SigH (PubMed:24705585).
CC {ECO:0000269|PubMed:19376862, ECO:0000269|PubMed:20701538,
CC ECO:0000269|PubMed:24705585, ECO:0000269|PubMed:25422323}.
CC -!- INDUCTION: Expression requires SigE and SigH (PubMed:19376862,
CC PubMed:20701538). Induced in response to environmental stress, such as
CC redox stress, heat shock, acid shock, SDS stress and thioridazine (THZ)
CC (PubMed:20701538, PubMed:19376862). Induced in host phagocytes
CC (PubMed:20701538). Induced by hypoxia and reaeration (PubMed:25422323).
CC {ECO:0000269|PubMed:19376862, ECO:0000269|PubMed:20701538,
CC ECO:0000269|PubMed:25422323}.
CC -!- DISRUPTION PHENOTYPE: Mutant is able to replicate without any defect
CC during hypoxia, but it is significantly impaired in its ability to
CC resume its growth during the subsequent reaeration phase.
CC {ECO:0000269|PubMed:25422323}.
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DR EMBL; AE000516; AAK47136.1; -; Genomic_DNA.
DR PIR; H70878; H70878.
DR RefSeq; WP_003414032.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WMH6; -.
DR SMR; P9WMH6; -.
DR EnsemblBacteria; AAK47136; AAK47136; MT2816.
DR GeneID; 45426732; -.
DR KEGG; mtc:MT2816; -.
DR PATRIC; fig|83331.31.peg.3036; -.
DR HOGENOM; CLU_066192_8_2_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Stress response; Transcription; Transcription regulation.
FT CHAIN 1..112
FT /note="Transcriptional regulator ClgR"
FT /id="PRO_0000427302"
FT DOMAIN 13..67
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT DNA_BIND 24..43
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ SEQUENCE 112 AA; 11786 MW; 0CAF56AACE6AD372 CRC64;
MAALVREVVG DVLRGARMSQ GRTLREVSDS ARVSLGYLSE IERGRKEPSS ELLSAICTAL
QLPLSVVLID AGERMARQER LARATPAGRA TGATIDASTK VVIAPVVSLA VA
