CLHC1_MOUSE
ID CLHC1_MOUSE Reviewed; 596 AA.
AC Q5M6W3; B2RQ04; Q9D9Q4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Clathrin heavy chain linker domain-containing protein 1;
GN Name=Clhc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK006591; BAB24663.1; -; mRNA.
DR EMBL; BX284634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137683; AAI37684.1; -; mRNA.
DR CCDS; CCDS48763.1; -.
DR RefSeq; NP_001156993.1; NM_001163521.1.
DR RefSeq; NP_082780.1; NM_028504.1.
DR RefSeq; XP_006514881.1; XM_006514818.1.
DR AlphaFoldDB; Q5M6W3; -.
DR SMR; Q5M6W3; -.
DR STRING; 10090.ENSMUSP00000020753; -.
DR iPTMnet; Q5M6W3; -.
DR PhosphoSitePlus; Q5M6W3; -.
DR MaxQB; Q5M6W3; -.
DR PaxDb; Q5M6W3; -.
DR PRIDE; Q5M6W3; -.
DR ProteomicsDB; 283299; -.
DR Antibodypedia; 30304; 23 antibodies from 9 providers.
DR DNASU; 73324; -.
DR Ensembl; ENSMUST00000020753; ENSMUSP00000020753; ENSMUSG00000020461.
DR GeneID; 73324; -.
DR KEGG; mmu:73324; -.
DR UCSC; uc007ihi.2; mouse.
DR CTD; 130162; -.
DR MGI; MGI:1920574; Clhc1.
DR VEuPathDB; HostDB:ENSMUSG00000020461; -.
DR eggNOG; KOG0985; Eukaryota.
DR GeneTree; ENSGT00950000183166; -.
DR HOGENOM; CLU_033164_0_0_1; -.
DR InParanoid; Q5M6W3; -.
DR OrthoDB; 665507at2759; -.
DR PhylomeDB; Q5M6W3; -.
DR TreeFam; TF328858; -.
DR BioGRID-ORCS; 73324; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Clhc1; mouse.
DR PRO; PR:Q5M6W3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5M6W3; protein.
DR Bgee; ENSMUSG00000020461; Expressed in spermatocyte and 29 other tissues.
DR ExpressionAtlas; Q5M6W3; baseline and differential.
DR Genevisible; Q5M6W3; MM.
DR Gene3D; 1.25.40.30; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012331; Clathrin_H-chain_linker.
DR InterPro; IPR017212; CLHC1.
DR InterPro; IPR032755; TSNAXIP1_N.
DR PANTHER; PTHR10292:SF11; PTHR10292:SF11; 1.
DR Pfam; PF15739; TSNAXIP1_N; 1.
DR PIRSF; PIRSF037469; Clathrin_H-chain-rel; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..596
FT /note="Clathrin heavy chain linker domain-containing
FT protein 1"
FT /id="PRO_0000325872"
FT COILED 129..241
FT /evidence="ECO:0000255"
FT CONFLICT 118
FT /note="T -> K (in Ref. 1; BAB24663)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 596 AA; 69414 MW; CFD336583827B224 CRC64;
MSVQEVNTHA VLPPIVSRND KEFLESIQRY ITTETKRVGC KEEGPADEYY TIYRNVFDKF
SATDRKIIFQ VIDYVSAYKS ILTAIKKEYD AFIETIKKGR RTAFYLHGKL KVLAKEPTAL
VYHQRRAIQL EAKMRIIENN STAIQLQIDQ MKQLRMEYDK KEVKLCAPSR QLWKPIPGMT
LQDSVNLEAL NKHKQYLEDK YIKLKQDMST MYVPAQKKAE LDEEMVVLLN RRDIAENLKK
DRQFRHQRLQ VISHTLTPWM KQNMRISFQD VMERIRKTKA IYGYDNIVDE IFEDDPNKKK
EAIVMLHYIE RFNDLISLGE YERAACFAAN SPKRILQNTS TMNKFKAIGK IRGKPLPLLL
FFEAIFNTSQ AFKRPINADL TMEGIKCGLS EERLDLVTHW VTQEKLTFSE KAGDIIFAYG
EQHTYHKPRC LALAQIIYNE CGLHRKALLC LCKQGQIHEA MEHIQQSKDI NTDDLIQLIT
ACPQIDLIRC LTQERNEKPP FLSFGLAVLH MFSVDMKKVG MRLLQEVSKG EKDVIEHLVM
SDLFCSLEKW QEIANICLQN GFKILFNDIM SILRSQAGVS EISEDDTTNI MEHVFW
