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CLIC6_HUMAN
ID   CLIC6_HUMAN             Reviewed;         704 AA.
AC   Q96NY7; A8K0U8; Q8IX31;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2003, sequence version 3.
DT   03-AUG-2022, entry version 177.
DE   RecName: Full=Chloride intracellular channel protein 6;
DE   AltName: Full=Parchorin;
GN   Name=CLIC6; Synonyms=CLIC1L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), AND ALTERNATIVE SPLICING.
RX   PubMed=14597386; DOI=10.1016/s0378-1119(03)00830-8;
RA   Friedli M., Guipponi M., Bertrand S., Bertrand D., Neerman-Arbez M.,
RA   Scott H.S., Antonarakis S.E., Reymond A.;
RT   "Identification of a novel member of the CLIC family, CLIC6, mapping to
RT   21q22.12.";
RL   Gene 320:31-40(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND TISSUE SPECIFICITY.
RX   PubMed=12226712; DOI=10.1007/s00335-001-2157-0;
RA   Strippoli P., D'Addabbo P., Lenzi L., Giannone S., Canaider S., Casadei R.,
RA   Vitale L., Carinci P., Zannotti M.;
RT   "Segmental paralogy in the human genome: a large-scale triplication on 1p,
RT   6p, and 21q.";
RL   Mamm. Genome 13:456-462(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC   TISSUE=Amygdala, and Small intestine;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 279-704 (ISOFORM A).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May insert into membranes and form chloride ion channels. May
CC       play a critical role in water-secreting cells, possibly through the
CC       regulation of chloride ion transport (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with dopamine receptors DRD2, DRD3 and DRD4.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
CC       Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell,
CC       it is translocated to the plasma membrane (By similarity).
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=B;
CC         IsoId=Q96NY7-1; Sequence=Displayed;
CC       Name=A;
CC         IsoId=Q96NY7-2; Sequence=VSP_008963;
CC   -!- TISSUE SPECIFICITY: Expressed in brain, placenta, pancreas and liver.
CC       {ECO:0000269|PubMed:12226712}.
CC   -!- DOMAIN: Members of this family may change from a globular, soluble
CC       state to a state where the N-terminal domain is inserted into the
CC       membrane and functions as chloride channel. A conformation change of
CC       the N-terminal domain is thought to expose hydrophobic surfaces that
CC       trigger membrane insertion (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chloride channel CLIC family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC03959.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF448439; AAN76730.1; -; mRNA.
DR   EMBL; AF448438; AAN76729.1; -; mRNA.
DR   EMBL; AF426169; AAL24813.1; -; mRNA.
DR   EMBL; AK092733; BAC03959.1; ALT_INIT; mRNA.
DR   EMBL; AK289663; BAF82352.1; -; mRNA.
DR   EMBL; AP001720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471079; EAX09775.1; -; Genomic_DNA.
DR   EMBL; BC040196; AAH40196.1; -; mRNA.
DR   CCDS; CCDS13638.1; -. [Q96NY7-2]
DR   CCDS; CCDS82669.1; -. [Q96NY7-1]
DR   RefSeq; NP_001303938.1; NM_001317009.1. [Q96NY7-1]
DR   RefSeq; NP_444507.1; NM_053277.2. [Q96NY7-2]
DR   AlphaFoldDB; Q96NY7; -.
DR   SMR; Q96NY7; -.
DR   BioGRID; 119900; 5.
DR   IntAct; Q96NY7; 1.
DR   STRING; 9606.ENSP00000290332; -.
DR   TCDB; 1.A.12.1.4; the intracellular chloride channel (clic) family.
DR   iPTMnet; Q96NY7; -.
DR   PhosphoSitePlus; Q96NY7; -.
DR   BioMuta; CLIC6; -.
DR   DMDM; 38372885; -.
DR   EPD; Q96NY7; -.
DR   jPOST; Q96NY7; -.
DR   MassIVE; Q96NY7; -.
DR   MaxQB; Q96NY7; -.
DR   PaxDb; Q96NY7; -.
DR   PeptideAtlas; Q96NY7; -.
DR   PRIDE; Q96NY7; -.
DR   ProteomicsDB; 77576; -. [Q96NY7-1]
DR   ProteomicsDB; 77577; -. [Q96NY7-2]
DR   Antibodypedia; 8114; 197 antibodies from 26 providers.
DR   DNASU; 54102; -.
DR   Ensembl; ENST00000349499.3; ENSP00000290332.4; ENSG00000159212.13. [Q96NY7-2]
DR   Ensembl; ENST00000360731.7; ENSP00000353959.3; ENSG00000159212.13. [Q96NY7-1]
DR   GeneID; 54102; -.
DR   KEGG; hsa:54102; -.
DR   MANE-Select; ENST00000349499.3; ENSP00000290332.4; NM_053277.3; NP_444507.1. [Q96NY7-2]
DR   UCSC; uc002yuf.2; human. [Q96NY7-1]
DR   CTD; 54102; -.
DR   DisGeNET; 54102; -.
DR   GeneCards; CLIC6; -.
DR   HGNC; HGNC:2065; CLIC6.
DR   HPA; ENSG00000159212; Group enriched (choroid plexus, stomach).
DR   MIM; 615321; gene.
DR   neXtProt; NX_Q96NY7; -.
DR   OpenTargets; ENSG00000159212; -.
DR   PharmGKB; PA26593; -.
DR   VEuPathDB; HostDB:ENSG00000159212; -.
DR   eggNOG; KOG1422; Eukaryota.
DR   GeneTree; ENSGT00940000159602; -.
DR   HOGENOM; CLU_023994_0_0_1; -.
DR   InParanoid; Q96NY7; -.
DR   OMA; QGASMEA; -.
DR   OrthoDB; 974249at2759; -.
DR   PhylomeDB; Q96NY7; -.
DR   TreeFam; TF315438; -.
DR   PathwayCommons; Q96NY7; -.
DR   SignaLink; Q96NY7; -.
DR   BioGRID-ORCS; 54102; 10 hits in 1067 CRISPR screens.
DR   ChiTaRS; CLIC6; human.
DR   GeneWiki; CLIC6; -.
DR   GenomeRNAi; 54102; -.
DR   Pharos; Q96NY7; Tbio.
DR   PRO; PR:Q96NY7; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q96NY7; protein.
DR   Bgee; ENSG00000159212; Expressed in pigmented layer of retina and 132 other tissues.
DR   Genevisible; Q96NY7; HS.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0031749; F:D2 dopamine receptor binding; IBA:GO_Central.
DR   GO; GO:0031750; F:D3 dopamine receptor binding; IBA:GO_Central.
DR   GO; GO:0031751; F:D4 dopamine receptor binding; IBA:GO_Central.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002946; CLIC.
DR   InterPro; IPR030257; CLIC-4/6.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR040079; Glutathione_S-Trfase.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR45476:SF1; PTHR45476:SF1; 2.
DR   PRINTS; PR01263; INTCLCHANNEL.
DR   SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR   SUPFAM; SSF47616; SSF47616; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR00862; O-ClC; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Chloride; Chloride channel; Cytoplasm;
KW   Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW   Repeat; Transmembrane; Transmembrane helix; Transport;
KW   Voltage-gated channel.
FT   CHAIN           1..704
FT                   /note="Chloride intracellular channel protein 6"
FT                   /id="PRO_0000144217"
FT   TRANSMEM        489..509
FT                   /note="Helical; Note=After insertion into the membrane"
FT                   /evidence="ECO:0000255"
FT   REPEAT          157..166
FT                   /note="1"
FT   REPEAT          167..176
FT                   /note="2"
FT   REPEAT          177..186
FT                   /note="3"
FT   REPEAT          187..196
FT                   /note="4"
FT   REPEAT          197..206
FT                   /note="5"
FT   REPEAT          207..216
FT                   /note="6"
FT   REPEAT          217..226
FT                   /note="7"
FT   REPEAT          227..236
FT                   /note="8"
FT   REPEAT          237..246
FT                   /note="9"
FT   REPEAT          247..256
FT                   /note="10"
FT   REPEAT          257..266
FT                   /note="11"
FT   REPEAT          267..276
FT                   /note="12"
FT   REPEAT          277..286
FT                   /note="13"
FT   DOMAIN          556..704
FT                   /note="GST C-terminal"
FT   REGION          1..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..282
FT                   /note="13 X 10 AA tandem repeat of G-D-[SNG]-[VIM]-[DEQ]-A-
FT                   [EAG]-[GDVE]-[PRG]-[LAVP]"
FT   COMPBIAS        11..25
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..146
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..446
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         44
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q811Q2"
FT   MOD_RES         397
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q811Q2"
FT   MOD_RES         442
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q811Q2"
FT   VAR_SEQ         459..476
FT                   /note="Missing (in isoform A)"
FT                   /evidence="ECO:0000303|PubMed:12226712,
FT                   ECO:0000303|PubMed:14597386, ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_008963"
FT   VARIANT         632
FT                   /note="D -> G (in dbSNP:rs3171439)"
FT                   /id="VAR_014139"
SQ   SEQUENCE   704 AA;  73012 MW;  A58F30E099BFE357 CRC64;
     MAEAAEPEGV APGPQGPPEV PAPLAERPGE PGAAGGEAEG PEGSEGAEEA PRGAAAVKEA
     GGGGPDRGPE AEARGTRGAH GETEAEEGAP EGAEVPQGGE ETSGAQQVEG ASPGRGAQGE
     PRGEAQREPE DSAAPERQEE AEQRPEVPEG SASGEAGDSV DAEGPLGDNI EAEGPAGDSV
     EAEGRVGDSV DAEGPAGDSV DAEGPLGDNI QAEGPAGDSV DAEGRVGDSV DAEGPAGDSV
     DAEGRVGDSV EAGDPAGDGV EAGVPAGDSV EAEGPAGDSM DAEGPAGRAR RVSGEPQQSG
     DGSLSPQAEA IEVAAGESAG RSPGELAWDA AEEAEVPGVK GSEEAAPGDA RADAGEDRVG
     DGPQQEPGED EERRERSPEG PREEEAAGGE EESPDSSPHG EASRGAAEPE AQLSNHLAEE
     GPAEGSGEAA RVNGRREDGE ASEPRALGQE HDITLFVKVK LTALGCSRIA IKKYLRAGYD
     GESIGNCPFS QRLFMILWLK GVIFNVTTVD LKRKPADLQN LAPGTNPPFM TFDGEVKTDV
     NKIEEFLEEK LAPPRYPKLG TQHPESNSAG NDVFAKFSAF IKNTKKDANE IHEKNLLKAL
     RKLDNYLNSP LPDEIDAYST EDVTVSGRKF LDGDELTLAD CNLLPKLHII KIVAKKYRDF
     EFPSEMTGIW RYLNNAYARD EFTNTCPADQ EIEHAYSDVA KRMK
 
 
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