ID   CLINK_FBNY2             Reviewed;         169 AA.
AC   O91253;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   29-SEP-2021, entry version 49.
DE   RecName: Full=Cell cycle link protein;
DE            Short=Clink;
GN   Name=DNA-C; Synonyms=C10;
OS   Faba bean necrotic yellows virus (isolate SV292-88) (FBNYV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Arfiviricetes;
OC   Mulpavirales; Nanoviridae; Nanovirus.
OX   NCBI_TaxID=291604;
OH   NCBI_TaxID=3827; Cicer arietinum (Chickpea) (Garbanzo).
OH   NCBI_TaxID=3864; Lens culinaris (Lentil) (Cicer lens).
OH   NCBI_TaxID=3885; Phaseolus vulgaris (Kidney bean) (French bean).
OH   NCBI_TaxID=3906; Vicia faba (Broad bean) (Faba vulgaris).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9880028; DOI=10.1099/0022-1317-79-12-3101;
RA   Katul L., Timchenko T., Gronenborn B., Vetten H.J.;
RT   "Ten distinct circular ssDNA components, four of which encode putative
RT   replication-associated proteins, are associated with the faba bean necrotic
RT   yellows virus genome.";
RL   J. Gen. Virol. 79:3101-3109(1998).
CC   -!- FUNCTION: Interacts with and disrupts the function of host
CC       retinoblastoma-related proteins RBR, which are key regulators of the
CC       cell cycle. Induces transcriptional activation of E2F-regulated S-phase
CC       and G2/M-phase-specific genes. Inactivation of the ability of RBR to
CC       arrest the cell cycle leads to the stimulation of viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host SKP1. Interacts (via LXCXE domain) with
CC       host retinoblastoma-related protein 1 (RBR1). Interacts (via LXCXE
CC       domain) with retinoblastoma-related proteins (RBR) (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nanovirus Clink protein family.
CC       {ECO:0000305}.
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DR   EMBL; AJ005967; CAA06790.1; -; Genomic_DNA.
DR   SMR; O91253; -.
DR   Proteomes; UP000008666; Genome.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..169
FT                   /note="Cell cycle link protein"
FT                   /id="PRO_0000338627"
FT   REGION          9..22
FT                   /note="Binding to host SKP1 protein"
FT                   /evidence="ECO:0000255"
FT   MOTIF           110..114
FT                   /note="LXCXE motif, interaction with host RBR"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   169 AA;  19684 MW;  F47BBDFE73236CE7 CRC64;
     MGLKYFSHLP EELRQKIVHD HLQQERKKEF LEKAIEDSCR RHVSLLKSDP SPSELYALSK
     FLDSLADYVG KQFNTRCLIK WKKDVPANIK FEVMEEQHLR LYGFVDMDDL LCREVLPPEE
     DDDITYEDGM IVNCSELDKL FEALGIKVVY ITVSKNCICT PLNKDIVIS